|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.140 |
GeneticVariation
|
disease |
BEFREE |
We also conducted a meta-analysis consisted of 11 studies and confirmed that SNP rs896854 in the TP53INP1 gene was associated with T2D risk.
|
29518490 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.140 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.
|
23300278 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.140 |
GeneticVariation
|
disease |
GWASCAT |
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
|
20581827 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.140 |
GeneticVariation
|
disease |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.140 |
GeneticVariation
|
disease |
GWASDB |
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
|
20581827 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.140 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association and meta-analysis in populations from Starr County, Texas, and Mexico City identify type 2 diabetes susceptibility loci and enrichment for expression quantitative trait loci in top signals.
|
21647700 |
2011 |
|
Eosinophil count procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Tumor Cell Invasion
|
0.080 |
GeneticVariation
|
phenotype |
BEFREE |
Specifically, the up‑ and downregulated genes included CCNE2, associated with DNA damage; ID3, associated with cell survival and 146 genes with a >2- to 3-fold change including the TP53INP1 gene, associated with DNA damage; CDC6, CDCA5, TAKMIP2, CDK14, CDK5, CDCA76, CDC25A, CDC5L and SKP2, associated with cell cycle; the CARD6, ID1 and ID2 genes, associated with cell survival and the BRMS1L, associated with cell migration and invasion.
|
26238775 |
2015 |
|
Malignant tumor of colon
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study was to test whether the Ca2+-dependent binding partner S100 protein is involved in CacyBP/SIP nuclear translocation in colon cancer SW480 cells.
|
29534068 |
2018 |
|
Colon Carcinoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study was to test whether the Ca2+-dependent binding partner S100 protein is involved in CacyBP/SIP nuclear translocation in colon cancer SW480 cells.
|
29534068 |
2018 |
|
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Downregulated DEGs included TFs, such as the proto‑oncogene SPI1, pre‑B‑cell leukemia homeobox 3 (PBX3) and lymphoid enhancer‑binding factor 1 (LEF1), as well as tumor suppressors (TSs), such as capping actin protein, gelsolin like (CAPG) and tumor protein p53‑inducible nuclear protein 1 (TP53INP1).
|
28791367 |
2017 |
|
Common ventricle
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
137 infants <1 year with SV with SIP undergoing care from January 2008 to June 2015 were retrospectively evaluated.
|
28770308 |
2017 |
|
Generalized Anxiety Disorder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Major depressive disorders (MDD) and generalized anxiety disorders (GAD) were diagnosed in 2006 and 2010 using the Mini International Neuropsychiatric Interview among 5684 workers from the French SIP cohort.
|
31377852 |
2020 |
|
Major Depressive Disorder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Major depressive disorders (MDD) and generalized anxiety disorders (GAD) were diagnosed in 2006 and 2010 using the Mini International Neuropsychiatric Interview among 5684 workers from the French SIP cohort.
|
31377852 |
2020 |
|
Single Ventricle Defect
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
137 infants <1 year with SV with SIP undergoing care from January 2008 to June 2015 were retrospectively evaluated.
|
28770308 |
2017 |
|
Bodily Pain
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
120 severely fatigued patients with type 1 diabetes completed questionnaires on pain (McGill Pain Questionnaire, MPQ; Short Form Health Survey subscale bodily pain, SF-36), fatigue severity (Checklist Individual Strength subscale fatigue severity, CIS), depressive symptoms (Beck Depression Inventory Primary Care, BDI-PC) and functional impairment (Sickness Impact Profile-8, SIP-8).
|
28314551 |
2017 |
|
Marijuana Use
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Mean (SD) number of marijuana use days was 16.4 (11.6), mean SIP-D 5.9 (9.0), mean ASSIST 12.5 (7.8); no significant association was found between anxiety/depression and marijuana use changes.
|
28984682 |
2019 |
|
Metabolic Syndrome X
|
0.200 |
Biomarker
|
disease |
MGD |
Colitis and colitis-associated cancer are exacerbated in mice deficient for tumor protein 53-induced nuclear protein 1.
|
17242209 |
2007 |
|
Metabolic Syndrome X
|
0.200 |
Biomarker
|
disease |
MGD |
In conclusion, this study highlights TP53INP1 as a molecular regulator of redox-driven metabolic syndrome and provides a new preclinical mouse model for metabolic syndrome clinical research.
|
25828351 |
2015 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.140 |
Biomarker
|
disease |
BEFREE |
In an effort to explore possible molecular links between T2DM and AD, the present study investigated the status of neurodegeneration, adult hippocampal neurogenesis, and nitrosative stress induced protein S-nitrosylation in streptozotocin (STZ) induced mice models of T2DM.
|
29147492 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.140 |
Biomarker
|
disease |
BEFREE |
Furthermore, among the 8 SNPs annotated at 6 different genes, 3 corresponding genes TP53INP1, TOMM40 and C8orf38 were related to mitochondrial dysfunction, critically involved in oxidative stress, which potentially contribute to the etiology of both AD and T2D.
|
28870582 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A comparative analysis of oncofetal fibronectin and tenascin-C incorporation in tumour vessels using human recombinant SIP format antibodies.
|
20237793 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Downregulated DEGs included TFs, such as the proto‑oncogene SPI1, pre‑B‑cell leukemia homeobox 3 (PBX3) and lymphoid enhancer‑binding factor 1 (LEF1), as well as tumor suppressors (TSs), such as capping actin protein, gelsolin like (CAPG) and tumor protein p53‑inducible nuclear protein 1 (TP53INP1).
|
28791367 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
After qRT-PCR confirmation, we followed up 8 genes (AKAP12, ARHGEF16, ARHGAP27, ENC1, PPP1R3C, PPP1R14C, RARRES1, and TP53INP1) by quantitative DNA methylation analysis using mass spectrometry of base-specific cleaved amplification products in panels of melanoma cell lines and fresh tumors.
|
18803327 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, the ectopic expression of their target gene myeloid differentiation primary response gene 88 (MYD88) or tumor protein 53-induced nuclear protein 1 (TP53INP1) combined with NT21MP enhanced the sensitivity of the breast cancer cells to paclitaxel.
|
30015868 |
2018 |