|
Metabolic Syndrome X
|
0.200 |
Biomarker
|
disease |
MGD |
In conclusion, this study highlights TP53INP1 as a molecular regulator of redox-driven metabolic syndrome and provides a new preclinical mouse model for metabolic syndrome clinical research.
|
25828351 |
2015 |
|
Metabolic Syndrome X
|
0.200 |
Biomarker
|
disease |
MGD |
Colitis and colitis-associated cancer are exacerbated in mice deficient for tumor protein 53-induced nuclear protein 1.
|
17242209 |
2007 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.140 |
GeneticVariation
|
disease |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.140 |
AlteredExpression
|
disease |
BEFREE |
Moreover, we demonstrate that the 3 non-canonical autophagy genes DRAM1, VAMP8 and TP53INP1 as differentially expressed between healthy and T2DM groups during myoblast differentiation, and that T53INP1 knock-down alters expression of both pro-and anti-apoptotic genes.
|
31160616 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.140 |
GeneticVariation
|
disease |
BEFREE |
We also conducted a meta-analysis consisted of 11 studies and confirmed that SNP rs896854 in the TP53INP1 gene was associated with T2D risk.
|
29518490 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.140 |
Biomarker
|
disease |
BEFREE |
In an effort to explore possible molecular links between T2DM and AD, the present study investigated the status of neurodegeneration, adult hippocampal neurogenesis, and nitrosative stress induced protein S-nitrosylation in streptozotocin (STZ) induced mice models of T2DM.
|
29147492 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.140 |
Biomarker
|
disease |
BEFREE |
Furthermore, among the 8 SNPs annotated at 6 different genes, 3 corresponding genes TP53INP1, TOMM40 and C8orf38 were related to mitochondrial dysfunction, critically involved in oxidative stress, which potentially contribute to the etiology of both AD and T2D.
|
28870582 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.140 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.
|
23300278 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.140 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association and meta-analysis in populations from Starr County, Texas, and Mexico City identify type 2 diabetes susceptibility loci and enrichment for expression quantitative trait loci in top signals.
|
21647700 |
2011 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.140 |
GeneticVariation
|
disease |
GWASCAT |
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
|
20581827 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.140 |
GeneticVariation
|
disease |
GWASDB |
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
|
20581827 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The protein and mRNA expression levels of TP53INP1, B-cell lymphoma 2 (Bcl-2)-associated-X and p21 were significantly increased, whereas those of Bcl-2 were significantly decreased in the miR-3934-5p inhibitor group, which was significantly reduced by TP53INP1 siRNA transfection. miR-3934-5p, as a tumor suppressor in NSCLC, may promote the sensitivity of cells to DDP by targeting TP53INP1, associated with the suppression of cell proliferation and promotion of apoptosis.
|
31410122 |
2019 |
|
Eosinophil count procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, the ectopic expression of their target gene myeloid differentiation primary response gene 88 (MYD88) or tumor protein 53-induced nuclear protein 1 (TP53INP1) combined with NT21MP enhanced the sensitivity of the breast cancer cells to paclitaxel.
|
30015868 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumour protein p53-inducible nuclear protein 1 (TP53INP1) is a tumour suppressor associated with malignant tumour metastasis.
|
29655255 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Previous studies demonstrated that SIP-SII, a sulfated derivative of SIP that is isolated from the ink of Sepiella maindroni, showed significant inhibition of tumor growth and metastasis.
|
28870748 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Downregulated DEGs included TFs, such as the proto‑oncogene SPI1, pre‑B‑cell leukemia homeobox 3 (PBX3) and lymphoid enhancer‑binding factor 1 (LEF1), as well as tumor suppressors (TSs), such as capping actin protein, gelsolin like (CAPG) and tumor protein p53‑inducible nuclear protein 1 (TP53INP1).
|
28791367 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Mechanistically, loss of ERBB4 suppressed p53 expression by inhibiting the expression of the tumor suppressor tp53inp1.
|
28334319 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Here, we report that the proapoptotic stress response factor TP53INP1 is often selectively downregulated in advanced stage IV and metastatic human HCC tumors.
|
28674078 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, we found that upregulated miR-182 inhibited the expression of tumor suppressor gene TP53INP1 (tumor protein 53-induced nuclear protein 1) in vitro.
|
24447717 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The MTT assay, FACS assay, clonogenic assay and tumor xenograft experiment were performed to assess the effect of CacyBP/SIP on cell growth and tumorigenesis in vitro and in vivo.
|
22295074 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Here, we have characterized a murine ortholog of the putative tumor suppressor gene DRR1 as a unique stress-induced protein in brain.
|
21969592 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A comparative analysis of oncofetal fibronectin and tenascin-C incorporation in tumour vessels using human recombinant SIP format antibodies.
|
20237793 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
After qRT-PCR confirmation, we followed up 8 genes (AKAP12, ARHGEF16, ARHGAP27, ENC1, PPP1R3C, PPP1R14C, RARRES1, and TP53INP1) by quantitative DNA methylation analysis using mass spectrometry of base-specific cleaved amplification products in panels of melanoma cell lines and fresh tumors.
|
18803327 |
2009 |
|
Tumor Cell Invasion
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, TNF-α/miR-155 axis promoted the cell proliferation, invasion and epithelial-mesenchymal transition (EMT) process in a TP53INP1 independent manner.
|
31669646 |
2020 |