CD68, CD68 molecule, 968

N. diseases: 452; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.080 Biomarker disease BEFREE Plasma from 16 patients with MS, eight with OND and 72 healthy donors were tested for antibodies by ELISA to HHV-6 early (p41/38) and late (gp110) proteins. 9987758 1998
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.010 AlteredExpression disease BEFREE Immunohistochemical studies of KSHV PCR+ MM BMSCs demonstrate expression of dendritic cell (DC) lineage markers (CD68, CD83, and fascin). 10029574 1999
CUI: C0851140
Disease: Carcinoma in situ of uterine cervix
Carcinoma in situ of uterine cervix 		0.010 AlteredExpression disease BEFREE Here, we demonstrate that high-grade dysplasia (CIN III, n = 9) completely lacks both MCP-1 expression and CD68+-macrophage infiltration, while MCP-1-specific signals were occasionally detectable in one out of 5 CIN-II and in one out of 3 CIN-I lesions. 10360812 1999
CUI: C3463824
Disease: MYELODYSPLASTIC SYNDROME
MYELODYSPLASTIC SYNDROME 		0.010 Biomarker group BEFREE Double immunostaining for CD68 antigen, which is a marker for macrophage lineage cells, and iNOS was performed on MDS bone marrow sections. iNOS was dominantly localized to bone marrow macrophages, although a part of myeloid cells were also positively stained with anti-iNOS antibody in a part of cases. 10374872 1999
CUI: C0403416
Disease: Idiopathic crescentic glomerulonephritis
Idiopathic crescentic glomerulonephritis 		0.010 Biomarker disease BEFREE Urinary MIP-1alpha levels in the patients with crescentic glomerulonephritis were well correlated with the percentage of cellular crescents and the number of CD68-positive infiltrating cells and CCR5-positive cells in the glomeruli. 10469367 1999
CUI: C0035455
Disease: Rhinitis
Rhinitis 		0.010 AlteredExpression disease BEFREE In aspirin-sensitive rhinitis there were increases in total (CD3+) (p=0.05) and activated (CD25+) T-cells (p=0.007), total (major basic protein (MBP) positive) (p=0.004) and activated (monoclonal antibody which recognizes the cleaved form of eosinophil cationic protein (EG2) positive) eosinophils (p=0.003), tryptase+ mast cells (p=0.04) and CD68+ macrophages (p=0.002). 10543283 1999
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.070 Biomarker disease BEFREE The portal tract (mean) density of CD68(+) and MAC387(+) cells was significantly increased in patients with HCV compared with normal tissue. 10644323 2000
CUI: C0524910
Disease: Hepatitis C, Chronic
Hepatitis C, Chronic 		0.010 Biomarker disease BEFREE Increases in intrahepatic CD68 positive cells, MAC387 positive cells, and proinflammatory cytokines (particularly interleukin 18) in chronic hepatitis C infection. 10644323 2000
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE This pattern of distribution was profoundly different from that of CD68+ macrophages, which were evenly distributed throughout the tumor. 10702399 2000
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.050 AlteredExpression disease BEFREE Synovial tissues obtained from 3 patients with HAAP and 3 patients with osteoarthritis (OA) were examined for the expression of tumor necrosis factor-alpha (TNF-alpha) mRNA, HTLV-I tax/rex mRNA, and number of CD68 by in situ reverse transcription assay and immunohistochemistry. 10782809 2000
CUI: C0022408
Disease: Arthropathy
Arthropathy 		0.010 AlteredExpression group BEFREE Synovial tissues obtained from 3 patients with HAAP and 3 patients with osteoarthritis (OA) were examined for the expression of tumor necrosis factor-alpha (TNF-alpha) mRNA, HTLV-I tax/rex mRNA, and number of CD68 by in situ reverse transcription assay and immunohistochemistry. 10782809 2000
CUI: C0023493
Disease: Adult T-Cell Lymphoma/Leukemia
Adult T-Cell Lymphoma/Leukemia 		0.010 Biomarker disease BEFREE To investigate the pathogenic role of macrophage lineage (CD68+) cells in synovial proliferation in patients with human T cell leukemia virus I (HTLV-I) associated arthropathy (HAAP). 10782809 2000
CUI: C0206139
Disease: Lichen Planus, Oral
Lichen Planus, Oral 		0.010 AlteredExpression disease BEFREE CD68 expression was significantly increased in the cellular infiltrate of all 30 cases of OLP compared with normal mucosa (P<0.009). 10890554 2000
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE TP was strongly expressed not only in CD68-positive macrophages in and around tumors, but also in S100 protein-positive melanoma cells, fibroblasts and keratinocytes. 11011118 2000
CUI: C0004096
Disease: Asthma
Asthma 		0.030 Biomarker disease BEFREE No differences in the numbers of CD68(+) macrophages and RFD1(+), RFD7(+), and RFD1(+)/RFD7(+) subpopulations were found between AA, NAA, AC, and NC subjects. 11031340 2000
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident 		0.020 Biomarker group BEFREE In this fibre tract, elevated MHC II-IR and CD68-IR were still detectable 1 year after trauma or stroke. 11045675 2000
CUI: C0025286
Disease: Meningioma
Meningioma 		0.020 Biomarker disease BEFREE The CD68 antigens, which are normally found on hematopoietic cells like macrophages and monocytes, were not detectable on meningioma cells in situ. 11131990 2000
CUI: C0278877
Disease: Adult Meningioma
Adult Meningioma 		0.010 Biomarker disease BEFREE The CD68 antigens, which are normally found on hematopoietic cells like macrophages and monocytes, were not detectable on meningioma cells in situ. 11131990 2000
CUI: C1762616
Disease: Meningioma, benign, no ICD-O subtype
Meningioma, benign, no ICD-O subtype 		0.010 Biomarker disease BEFREE The CD68 antigens, which are normally found on hematopoietic cells like macrophages and monocytes, were not detectable on meningioma cells in situ. 11131990 2000
CUI: C0346210
Disease: Vulval intraepithelial neoplasia
Vulval intraepithelial neoplasia 		0.010 Biomarker disease BEFREE Compared with normal vulval skin, VIN lesions showed increased infiltration by CD4 (T-helper) and CD68 (macrophages) but not CD1a (Langerhans cells) or CD8 (CTLs). 11196160 2001
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.100 Biomarker disease BEFREE An immunohistochemical study confirmed the expression of cathepsins B and L by CD68-positive mononuclear cells at the sites of significant cartilage and bone erosion from the subchondral region in all RA specimens. 11285370 2001
CUI: C0333307
Disease: Superficial ulcer
Superficial ulcer 		0.010 Biomarker disease BEFREE An immunohistochemical study confirmed the expression of cathepsins B and L by CD68-positive mononuclear cells at the sites of significant cartilage and bone erosion from the subchondral region in all RA specimens. 11285370 2001
CUI: C3887524
Disease: Skin Erosion
Skin Erosion 		0.010 Biomarker disease BEFREE An immunohistochemical study confirmed the expression of cathepsins B and L by CD68-positive mononuclear cells at the sites of significant cartilage and bone erosion from the subchondral region in all RA specimens. 11285370 2001
CUI: C0206180
Disease: Ki-1+ Anaplastic Large Cell Lymphoma
Ki-1+ Anaplastic Large Cell Lymphoma 		0.010 Biomarker disease BEFREE Cell morphology, immunophenotype (CD30-, EMA-, Lisozyme+, cy CD68+ and CD45+) and DNA analysis showing germ-line configuration of the Ig/TCR chain genes ruled out the diagnosis of anaplastic large cell lymphoma (ALCL). 11378558 2001
CUI: C0008495
Disease: Chorioamnionitis
Chorioamnionitis 		0.040 Biomarker phenotype BEFREE Fetal lungs showed a marked increase in the presence of histologically confirmed chorioamnionitis in densities of CD68(+) macrophages (68 vs 9.5 cells/5 mm(2), median group vs control group; P =.02) and lymphocytes (7 vs 2.5 cells/5 mm(2), median chorioamnionitis vs control group; P =.05) and a similar but lesser increase in neutrophil density (16 vs 4 cells/5 mm(2); difference not significant). 11483924 2001