rs16969968
×
Entrez Id:
1138
Gene Symbol:
CHRNA5
CHRNA5
Chronic Obstructive Airway Disease
A
0.780
GeneticVariation
GWASCAT
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
26634245
2015
rs11633958
×
Entrez Id:
1138
Gene Symbol:
CHRNA5
CHRNA5
Chronic Obstructive Airway Disease
T
0.700
GeneticVariation
GWASCAT
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
26634245
2015
rs140330585
×
Entrez Id:
1138
Gene Symbol:
CHRNA5
CHRNA5
Chronic Obstructive Airway Disease
A
0.700
GeneticVariation
GWASCAT
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
26634245
2015
rs17486195
×
Entrez Id:
1138
Gene Symbol:
CHRNA5
CHRNA5
Chronic Obstructive Airway Disease
A
0.700
GeneticVariation
GWASCAT
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
26634245
2015
rs17486278
×
Entrez Id:
1138
Gene Symbol:
CHRNA5
CHRNA5
Chronic Obstructive Airway Disease
A
0.700
GeneticVariation
GWASCAT
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
26634245
2015
rs190065944
×
Entrez Id:
1138
Gene Symbol:
CHRNA5
CHRNA5
Chronic Obstructive Airway Disease
A
0.700
GeneticVariation
GWASCAT
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
26634245
2015
rs4887067
CHRNA3;CHRNA5
Chronic Obstructive Airway Disease
A
0.700
GeneticVariation
GWASCAT
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
26634245
2015
rs55781567
×
Entrez Id:
1138
Gene Symbol:
CHRNA5
CHRNA5
Chronic Obstructive Airway Disease
C
0.700
GeneticVariation
GWASCAT
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
26634245
2015
rs55853698
×
Entrez Id:
1138
Gene Symbol:
CHRNA5
CHRNA5
Chronic Obstructive Airway Disease
T
0.700
GeneticVariation
GWASCAT
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
26634245
2015
rs56390833
×
Entrez Id:
1138
Gene Symbol:
CHRNA5
CHRNA5
Chronic Obstructive Airway Disease
A
0.700
GeneticVariation
GWASCAT
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
26634245
2015
rs7172118
×
Entrez Id:
1138
Gene Symbol:
CHRNA5
CHRNA5
Chronic Obstructive Airway Disease
A
0.700
GeneticVariation
GWASCAT
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
26634245
2015
rs7180002
×
Entrez Id:
1138
Gene Symbol:
CHRNA5
CHRNA5
Chronic Obstructive Airway Disease
A
0.700
GeneticVariation
GWASCAT
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
26634245
2015
rs72740964
×
Entrez Id:
1138
Gene Symbol:
CHRNA5
CHRNA5
Chronic Obstructive Airway Disease
A
0.700
GeneticVariation
GWASCAT
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
26634245
2015
rs8192482
CHRNA3;CHRNA5
Chronic Obstructive Airway Disease
T
0.700
GeneticVariation
GWASCAT
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
26634245
2015
rs951266
×
Entrez Id:
1138
Gene Symbol:
CHRNA5
CHRNA5
Chronic Obstructive Airway Disease
A
0.700
GeneticVariation
GWASCAT
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
26634245
2015
rs8192482
CHRNA3;CHRNA5
Chronic Obstructive Airway Disease
T
0.700
GeneticVariation
GWASCAT
Common and Rare Variants Genetic Association Analysis of Cigarettes per Day Among Ever-Smokers in Chronic Obstructive Pulmonary Disease Cases and Controls.
29767774
2019
rs16969968
×
Entrez Id:
1138
Gene Symbol:
CHRNA5
CHRNA5
Chronic Obstructive Airway Disease
0.780
GeneticVariation
BEFREE
Four SNPs (rs1964678, rs12593229, rs965604 and rs13180) in IREB2 were associated with forced expiratory volume in 1 s (FEV(1))% predicted and three SNPs (rs16969968 , rs8034191 and rs1051730) in CHRNA3/5 were both associated with FEV(1)% predicted and FEV(1)/FVC in COPD cases (P range 0.007-0.050).
22914670
2012
rs17486278
×
Entrez Id:
1138
Gene Symbol:
CHRNA5
CHRNA5
Chronic Obstructive Airway Disease
C
0.700
GeneticVariation
GWASCAT
Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis.
28166215
2017
rs16969968
×
Entrez Id:
1138
Gene Symbol:
CHRNA5
CHRNA5
Chronic Obstructive Airway Disease
0.780
GeneticVariation
BEFREE
In addition, the A alleles in CHRNA3 rs1051730 and CHRNA5 rs16969968 were associated with the risk for LC (OR = 1.66, P = 0.07 and OR = 1.57, P = 0.1, respectively) and for COPD (OR = 2.04, P = 0.01 and OR = 1.91, P = 0.02, respectively).
29993116
2018
rs16969968
×
Entrez Id:
1138
Gene Symbol:
CHRNA5
CHRNA5
Chronic Obstructive Airway Disease
0.780
GeneticVariation
BEFREE
In models adjusting for cigarettes-per-day, we confirm the association between rs16969968 and lung cancer (p<10(-20)) and observe a nominally significant association with COPD (p = 0.01); the other loci are not significantly associated with either lung cancer or COPD after adjusting for rs16969968 .
20700436
2010
rs76071148
CHRNA3;CHRNA5
Chronic Obstructive Airway Disease
0.010
GeneticVariation
BEFREE
In summary, we determined that rs8040868 and rs76071148 are promising indicators of the degree of emphysema and chest CT manifestations, especially in spirometry-diagnosed non-COPD subjects.
28553097
2017
rs17486278
×
Entrez Id:
1138
Gene Symbol:
CHRNA5
CHRNA5
Chronic Obstructive Airway Disease
C
0.700
GeneticVariation
GWASCAT
IREB2 and GALC are associated with pulmonary artery enlargement in chronic obstructive pulmonary disease.
25101718
2015
rs16969968
×
Entrez Id:
1138
Gene Symbol:
CHRNA5
CHRNA5
Chronic Obstructive Airway Disease
0.780
GeneticVariation
BEFREE
Our study showed the association of rs13180, rs16969968 and rs1051730 with COPD and lung function in Tatar population from Russia.
28474623
2016
rs16969968
×
Entrez Id:
1138
Gene Symbol:
CHRNA5
CHRNA5
Chronic Obstructive Airway Disease
0.780
GeneticVariation
BEFREE
Our top result was rs16969968 (P = 1.7 × 10(-14)) in CHRNA5, a locus previously associated with COPD susceptibility and nicotine dependence.
26771213
2016
rs16969968
×
Entrez Id:
1138
Gene Symbol:
CHRNA5
CHRNA5
Chronic Obstructive Airway Disease
0.780
GeneticVariation
BEFREE
Significant associations between the 4 SNPs and COPD were identified under allele (rs1051730: OR = 1.14, 95%CI = 1.10-1.18; rs8034191: OR = 1.29, 95%CI = 1.18-1.41; rs6495309: OR = 1.26, 95%CI = 1.09-1.45; rs16969968 : OR = 1.27, 95%CI = 1.17-1.39) and genotype models.
25051068
2014