rs16969968
×
Entrez Id:
1138
Gene Symbol:
CHRNA5
CHRNA5
Chronic Obstructive Airway Disease
0.780
GeneticVariation
BEFREE
In addition, the A alleles in CHRNA3 rs1051730 and CHRNA5 rs16969968 were associated with the risk for LC (OR = 1.66, P = 0.07 and OR = 1.57, P = 0.1, respectively) and for COPD (OR = 2.04, P = 0.01 and OR = 1.91, P = 0.02, respectively).
29993116
2018
rs16969968
×
Entrez Id:
1138
Gene Symbol:
CHRNA5
CHRNA5
Chronic Obstructive Airway Disease
0.780
GeneticVariation
BEFREE
Our study showed the association of rs13180, rs16969968 and rs1051730 with COPD and lung function in Tatar population from Russia.
28474623
2016
rs16969968
×
Entrez Id:
1138
Gene Symbol:
CHRNA5
CHRNA5
Chronic Obstructive Airway Disease
0.780
GeneticVariation
BEFREE
The rs8040868 variant is in linkage disequilibrium with rs16969968 previously associated with COPD and altered expression of the CHRNA5 gene.
27835950
2016
rs16969968
×
Entrez Id:
1138
Gene Symbol:
CHRNA5
CHRNA5
Chronic Obstructive Airway Disease
0.780
GeneticVariation
BEFREE
The FPRP test results were as follows: 1) when the prior probability was 0.001 and the OR was 1.5, ADAM33 rs612709, CHRNA3/5 rs1051730, CHRNA3/5 rs8034191, CHRNA3/5 rs16969968 , and TGFB1 rs1800470 were truly associated with COPD risk (FPRP < 0.2); 2) when the prior probability was 0.000001 and the OR was 1.5, all the variants except TGFB1 rs1800470 remained noteworthy; and 3) when the probability was 0.000001 and the OR was 1.2, ADAM33 rs612709 and CHRNA3/5 rs1051730 remained true positives.
27323020
2016
rs16969968
×
Entrez Id:
1138
Gene Symbol:
CHRNA5
CHRNA5
Chronic Obstructive Airway Disease
0.780
GeneticVariation
BEFREE
Our top result was rs16969968 (P = 1.7 × 10(-14)) in CHRNA5, a locus previously associated with COPD susceptibility and nicotine dependence.
26771213
2016
rs16969968
×
Entrez Id:
1138
Gene Symbol:
CHRNA5
CHRNA5
Chronic Obstructive Airway Disease
A
0.780
GeneticVariation
GWASCAT
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
26634245
2015
rs16969968
×
Entrez Id:
1138
Gene Symbol:
CHRNA5
CHRNA5
Chronic Obstructive Airway Disease
0.780
GeneticVariation
BEFREE
Significant associations between the 4 SNPs and COPD were identified under allele (rs1051730: OR = 1.14, 95%CI = 1.10-1.18; rs8034191: OR = 1.29, 95%CI = 1.18-1.41; rs6495309: OR = 1.26, 95%CI = 1.09-1.45; rs16969968 : OR = 1.27, 95%CI = 1.17-1.39) and genotype models.
25051068
2014
rs16969968
×
Entrez Id:
1138
Gene Symbol:
CHRNA5
CHRNA5
Chronic Obstructive Airway Disease
0.780
GeneticVariation
BEFREE
Four SNPs (rs1964678, rs12593229, rs965604 and rs13180) in IREB2 were associated with forced expiratory volume in 1 s (FEV(1))% predicted and three SNPs (rs16969968 , rs8034191 and rs1051730) in CHRNA3/5 were both associated with FEV(1)% predicted and FEV(1)/FVC in COPD cases (P range 0.007-0.050).
22914670
2012
rs16969968
×
Entrez Id:
1138
Gene Symbol:
CHRNA5
CHRNA5
Chronic Obstructive Airway Disease
0.780
GeneticVariation
BEFREE
In models adjusting for cigarettes-per-day, we confirm the association between rs16969968 and lung cancer (p<10(-20)) and observe a nominally significant association with COPD (p = 0.01); the other loci are not significantly associated with either lung cancer or COPD after adjusting for rs16969968 .
20700436
2010
rs8192482
CHRNA3;CHRNA5
Chronic Obstructive Airway Disease
T
0.700
GeneticVariation
GWASCAT
Common and Rare Variants Genetic Association Analysis of Cigarettes per Day Among Ever-Smokers in Chronic Obstructive Pulmonary Disease Cases and Controls.
29767774
2019
rs17486278
×
Entrez Id:
1138
Gene Symbol:
CHRNA5
CHRNA5
Chronic Obstructive Airway Disease
C
0.700
GeneticVariation
GWASCAT
Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis.
28166215
2017
rs11633958
×
Entrez Id:
1138
Gene Symbol:
CHRNA5
CHRNA5
Chronic Obstructive Airway Disease
T
0.700
GeneticVariation
GWASCAT
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
26634245
2015
rs140330585
×
Entrez Id:
1138
Gene Symbol:
CHRNA5
CHRNA5
Chronic Obstructive Airway Disease
A
0.700
GeneticVariation
GWASCAT
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
26634245
2015
rs17486195
×
Entrez Id:
1138
Gene Symbol:
CHRNA5
CHRNA5
Chronic Obstructive Airway Disease
A
0.700
GeneticVariation
GWASCAT
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
26634245
2015
rs17486278
×
Entrez Id:
1138
Gene Symbol:
CHRNA5
CHRNA5
Chronic Obstructive Airway Disease
C
0.700
GeneticVariation
GWASCAT
IREB2 and GALC are associated with pulmonary artery enlargement in chronic obstructive pulmonary disease.
25101718
2015
rs17486278
×
Entrez Id:
1138
Gene Symbol:
CHRNA5
CHRNA5
Chronic Obstructive Airway Disease
A
0.700
GeneticVariation
GWASCAT
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
26634245
2015
rs190065944
×
Entrez Id:
1138
Gene Symbol:
CHRNA5
CHRNA5
Chronic Obstructive Airway Disease
A
0.700
GeneticVariation
GWASCAT
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
26634245
2015
rs4887067
CHRNA3;CHRNA5
Chronic Obstructive Airway Disease
A
0.700
GeneticVariation
GWASCAT
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
26634245
2015
rs55781567
×
Entrez Id:
1138
Gene Symbol:
CHRNA5
CHRNA5
Chronic Obstructive Airway Disease
C
0.700
GeneticVariation
GWASCAT
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
26634245
2015
rs55853698
×
Entrez Id:
1138
Gene Symbol:
CHRNA5
CHRNA5
Chronic Obstructive Airway Disease
T
0.700
GeneticVariation
GWASCAT
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
26634245
2015
rs56390833
×
Entrez Id:
1138
Gene Symbol:
CHRNA5
CHRNA5
Chronic Obstructive Airway Disease
A
0.700
GeneticVariation
GWASCAT
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
26634245
2015
rs7172118
×
Entrez Id:
1138
Gene Symbol:
CHRNA5
CHRNA5
Chronic Obstructive Airway Disease
A
0.700
GeneticVariation
GWASCAT
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
26634245
2015
rs7180002
×
Entrez Id:
1138
Gene Symbol:
CHRNA5
CHRNA5
Chronic Obstructive Airway Disease
A
0.700
GeneticVariation
GWASCAT
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
26634245
2015
rs72740964
×
Entrez Id:
1138
Gene Symbol:
CHRNA5
CHRNA5
Chronic Obstructive Airway Disease
A
0.700
GeneticVariation
GWASCAT
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
26634245
2015
rs8192482
CHRNA3;CHRNA5
Chronic Obstructive Airway Disease
T
0.700
GeneticVariation
GWASCAT
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
26634245
2015