COLCA2, colorectal cancer associated 2, 120376

N. diseases: 12; N. variants: 3
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs3802842
rs3802842
Entrez Id: 120376;399948
Gene Symbol: COLCA2;COLCA1
COLCA2;COLCA1
CUI: C1319315
Disease:
Adenocarcinoma of large intestine 		0.700 GeneticVariation GWASCAT Meta-analysis of new genome-wide association studies of colorectal cancer risk. 21761138 2012
dbSNP: rs3802842
rs3802842
Entrez Id: 120376;399948
Gene Symbol: COLCA2;COLCA1
COLCA2;COLCA1
CUI: C1319315
Disease:
Adenocarcinoma of large intestine 		C 0.700 GeneticVariation GWASCAT Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk. 26965516 2016
dbSNP: rs3802842
rs3802842
Entrez Id: 120376;399948
Gene Symbol: COLCA2;COLCA1
COLCA2;COLCA1
CUI: C1319315
Disease:
Adenocarcinoma of large intestine 		C 0.700 GeneticVariation GWASCAT Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. 18372901 2008
dbSNP: rs3802842
rs3802842
Entrez Id: 120376;399948
Gene Symbol: COLCA2;COLCA1
COLCA2;COLCA1
CUI: C1319315
Disease:
Adenocarcinoma of large intestine 		0.700 GeneticVariation GWASCAT Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. 23266556 2013
dbSNP: rs3802842
rs3802842
Entrez Id: 120376;399948
Gene Symbol: COLCA2;COLCA1
COLCA2;COLCA1
CUI: C1319315
Disease:
Adenocarcinoma of large intestine 		C 0.700 GeneticVariation GWASCAT Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. 24836286 2014
dbSNP: rs3802842
rs3802842
Entrez Id: 120376;399948
Gene Symbol: COLCA2;COLCA1
COLCA2;COLCA1
CUI: C1319315
Disease:
Adenocarcinoma of large intestine 		C 0.700 GeneticVariation GWASCAT Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer. 30529582 2019
dbSNP: rs3802842
rs3802842
Entrez Id: 120376;399948
Gene Symbol: COLCA2;COLCA1
COLCA2;COLCA1
CUI: C1319315
Disease:
Adenocarcinoma of large intestine 		C 0.700 GeneticVariation GWASCAT Genome-wide association study of colorectal cancer identifies six new susceptibility loci. 26151821 2015
dbSNP: rs3802842
rs3802842
Entrez Id: 120376;399948
Gene Symbol: COLCA2;COLCA1
COLCA2;COLCA1
CUI: C1319315
Disease:
Adenocarcinoma of large intestine 		C 0.700 GeneticVariation GWASCAT Novel Common Genetic Susceptibility Loci for Colorectal Cancer. 29917119 2019
dbSNP: rs6589219
rs6589219
Entrez Id: 120376;399948
Gene Symbol: COLCA2;COLCA1
COLCA2;COLCA1
CUI: C1319315
Disease:
Adenocarcinoma of large intestine 		G 0.700 GeneticVariation GWASCAT Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci. 28960316 2018
dbSNP: rs3802842
rs3802842
Entrez Id: 120376;399948
Gene Symbol: COLCA2;COLCA1
COLCA2;COLCA1
CUI: C0001430
Disease:
Adenoma 		0.010 GeneticVariation BEFREE The CRC SNPs accounted for 4.3% of the variation in multiple adenoma risk, with three SNPs (rs6983267, rs10795668, rs3802842) explaining 3.0% of the variation. 24801760 2015
dbSNP: rs3802842
rs3802842
Entrez Id: 120376;399948
Gene Symbol: COLCA2;COLCA1
COLCA2;COLCA1
CUI: C0237123
Disease:
Alcohol or Other Drugs use 		0.010 GeneticVariation BEFREE We used meta-analysis of an efficient empirical-Bayes estimator to detect potential multiplicative interactions between each of the SNPs [rs16892766 at 8q23.3 (EIF3H/UTP23), rs6983267 at 8q24 (MYC), rs10795668 at 10p14 (FLJ3802842), rs3802842 at 11q23 (LOC120376), rs4444235 at 14q22.2 (BMP4), rs4779584 at 15q13 (GREM1), rs9929218 at 16q22.1 (CDH1), rs4939827 at 18q21 (SMAD7), rs10411210 at 19q13.1 (RHPN2), and rs961253 at 20p12.3 (BMP2)] and select major CRC risk factors (sex, body mass index, height, smoking status, aspirin/nonsteroidal anti-inflammatory drug use, alcohol use, and dietary intake of calcium, folate, red meat, processed meat, vegetables, fruit, and fiber). 22367214 2012
dbSNP: rs3802842
rs3802842
Entrez Id: 120376;399948
Gene Symbol: COLCA2;COLCA1
COLCA2;COLCA1
CUI: C0595989
Disease:
Carcinoma of larynx 		0.010 GeneticVariation BEFREE Univariate cox regression analysis indicated that four SNPs were associated (p < 0.05) with LC OS in the codominant genetic model compared to patients with the homozygous wild-type genotype: rs10088262 G/A (HR = 1.57), rs1665650 A/G (HR = 0.65); rs3802842 C/C (HR = 2.18), and rs59336 T/A and T/T (HR = 0.61 and 2.61, respectively). 28052013 2017
dbSNP: rs3802842
rs3802842
Entrez Id: 120376;399948
Gene Symbol: COLCA2;COLCA1
COLCA2;COLCA1
CUI: C0699790
Disease:
Colon Carcinoma 		0.020 GeneticVariation BEFREE A total of 927 MMR gene mutation carriers (360 MLH1, 442 MSH2, 85 MSH6 and 40 PMS2) from 315 families enrolled in the Colon Cancer Family Registry, were genotyped for the single nucleotide polymorphisms (SNPs): rs16892766 (8q23.3), rs6983267 (8q24.21), rs719725 (9p24), rs10795668 (10p14), rs3802842 (11q23.1), rs4444235 (14q22.2), rs4779584 (15q13.3), rs9929218 (16q22.1), rs4939827 (18q21.1), rs10411210 (19q13.1) and rs961253 (20p12.3). 23434150 2013
dbSNP: rs3802842
rs3802842
Entrez Id: 120376;399948
Gene Symbol: COLCA2;COLCA1
COLCA2;COLCA1
CUI: C0699790
Disease:
Colon Carcinoma 		0.020 GeneticVariation BEFREE Risk was greater for rectal than for colon cancer for rs3802842 (P < 0.008) and rs4939827 (P < 0.009). 18372901 2008
dbSNP: rs3802842
rs3802842
Entrez Id: 120376;399948
Gene Symbol: COLCA2;COLCA1
COLCA2;COLCA1
CUI: C0009373
Disease:
Colonic Diseases 		0.010 GeneticVariation BEFREE Several loci showed statistically significant associations with specific phenotypes notably rs6691170 and rs3802842 associated with microsatellite stable rectal disease; rs4779584, rs961253 and rs4813802 associated with microsatellite stable colonic disease and rs4444235 and rs4925386 with microsatellite instability colonic disease. 22045029 2012
dbSNP: rs3802842
rs3802842
Entrez Id: 120376;399948
Gene Symbol: COLCA2;COLCA1
COLCA2;COLCA1
CUI: C1837315
Disease:
COLORECTAL CANCER, SUSCEPTIBILITY TO, 1 		C 0.700 GeneticVariation GWASCAT Novel Common Genetic Susceptibility Loci for Colorectal Cancer. 29917119 2019
dbSNP: rs3802842
rs3802842
Entrez Id: 120376;399948
Gene Symbol: COLCA2;COLCA1
COLCA2;COLCA1
CUI: C1837315
Disease:
COLORECTAL CANCER, SUSCEPTIBILITY TO, 1 		C 0.700 GeneticVariation GWASCAT Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. 24836286 2014
dbSNP: rs3802842
rs3802842
Entrez Id: 120376;399948
Gene Symbol: COLCA2;COLCA1
COLCA2;COLCA1
CUI: C1837315
Disease:
COLORECTAL CANCER, SUSCEPTIBILITY TO, 1 		C 0.700 GeneticVariation GWASCAT Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer. 30529582 2019
dbSNP: rs3802842
rs3802842
Entrez Id: 120376;399948
Gene Symbol: COLCA2;COLCA1
COLCA2;COLCA1
CUI: C1837315
Disease:
COLORECTAL CANCER, SUSCEPTIBILITY TO, 1 		C 0.700 GeneticVariation GWASCAT Genome-wide association study of colorectal cancer identifies six new susceptibility loci. 26151821 2015
dbSNP: rs3802842
rs3802842
Entrez Id: 120376;399948
Gene Symbol: COLCA2;COLCA1
COLCA2;COLCA1
CUI: C1837315
Disease:
COLORECTAL CANCER, SUSCEPTIBILITY TO, 1 		C 0.700 GeneticVariation GWASCAT Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk. 26965516 2016
dbSNP: rs3802842
rs3802842
Entrez Id: 120376;399948
Gene Symbol: COLCA2;COLCA1
COLCA2;COLCA1
CUI: C1837315
Disease:
COLORECTAL CANCER, SUSCEPTIBILITY TO, 1 		C 0.700 GeneticVariation GWASCAT Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. 18372901 2008
dbSNP: rs3802842
rs3802842
Entrez Id: 120376;399948
Gene Symbol: COLCA2;COLCA1
COLCA2;COLCA1
CUI: C1837315
Disease:
COLORECTAL CANCER, SUSCEPTIBILITY TO, 1 		0.700 GeneticVariation GWASCAT Meta-analysis of new genome-wide association studies of colorectal cancer risk. 21761138 2012
dbSNP: rs3802842
rs3802842
Entrez Id: 120376;399948
Gene Symbol: COLCA2;COLCA1
COLCA2;COLCA1
CUI: C1837315
Disease:
COLORECTAL CANCER, SUSCEPTIBILITY TO, 1 		0.700 GeneticVariation GWASCAT Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. 23266556 2013
dbSNP: rs6589219
rs6589219
Entrez Id: 120376;399948
Gene Symbol: COLCA2;COLCA1
COLCA2;COLCA1
CUI: C1837315
Disease:
COLORECTAL CANCER, SUSCEPTIBILITY TO, 1 		G 0.700 GeneticVariation GWASCAT Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci. 28960316 2018
dbSNP: rs3802842
rs3802842
Entrez Id: 120376;399948
Gene Symbol: COLCA2;COLCA1
COLCA2;COLCA1
CUI: C2675481
Disease:
COLORECTAL CANCER, SUSCEPTIBILITY TO, 10 		C 0.700 GeneticVariation GWASCAT Genome-wide association study of colorectal cancer identifies six new susceptibility loci. 26151821 2015