|
rs3802842
|
COLCA2;COLCA1
|
Carcinoma of larynx
|
|
0.010 |
GeneticVariation |
BEFREE |
Univariate cox regression analysis indicated that four SNPs were associated (p < 0.05) with LC OS in the codominant genetic model compared to patients with the homozygous wild-type genotype: rs10088262 G/A (HR = 1.57), rs1665650 A/G (HR = 0.65); rs3802842 C/C (HR = 2.18), and rs59336 T/A and T/T (HR = 0.61 and 2.61, respectively).
|
28052013 |
2017 |
|
rs3802842
|
COLCA2;COLCA1
|
Neoplasms
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified two risk alleles that were significant cis-eQTLs for FADS2 (rs1535) and COLCA1 and 2 (rs3802842) genes in the normal transverse colon tissue and two risk alleles that were significant cis-eQTLs for the CABLES2 (rs2427308) and LIPG (rs7229639) genes in the normal sigmoid colon tissue, but not tumor tissue.
|
28506205 |
2017 |
|
rs3802842
|
COLCA2;COLCA1
|
Malignant neoplasm of colon and/or rectum
|
|
0.010 |
GeneticVariation |
BEFREE |
Common genetic variant rs3802842 in 11q23 contributes to colorectal cancer risk in Chinese population.
|
29069782 |
2017 |
|
rs3802842
|
COLCA2;COLCA1
|
Esophageal Neoplasms
|
|
0.010 |
GeneticVariation |
BEFREE |
In the genetic model analysis, the C/C genotype of rs3802842 was associated with a reduced risk of esophageal cancer in the codominant model (OR = 0.52, 95%CI: 0.31-0.88; P = 0.033) and recessive model (OR = 0.55, 95%CI: 0.34-0.87; P = 0.010).
|
26078566 |
2015 |
|
rs3802842
|
COLCA2;COLCA1
|
Adenoma
|
|
0.010 |
GeneticVariation |
BEFREE |
The CRC SNPs accounted for 4.3% of the variation in multiple adenoma risk, with three SNPs (rs6983267, rs10795668, rs3802842) explaining 3.0% of the variation.
|
24801760 |
2015 |
|
rs3802842
|
COLCA2;COLCA1
|
Malignant neoplasm of esophagus
|
|
0.010 |
GeneticVariation |
BEFREE |
In the genetic model analysis, the C/C genotype of rs3802842 was associated with a reduced risk of esophageal cancer in the codominant model (OR = 0.52, 95%CI: 0.31-0.88; P = 0.033) and recessive model (OR = 0.55, 95%CI: 0.34-0.87; P = 0.010).
|
26078566 |
2015 |
|
rs3802842
|
COLCA2;COLCA1
|
Esophageal carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
In the genetic model analysis, the C/C genotype of rs3802842 was associated with a reduced risk of esophageal cancer in the codominant model (OR = 0.52, 95%CI: 0.31-0.88; P = 0.033) and recessive model (OR = 0.55, 95%CI: 0.34-0.87; P = 0.010).
|
26078566 |
2015 |
|
rs10891246
|
COLCA2;COLCA1
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
These data imply that rs10891246 and rs7130173 are functional SNPs mapping to 11q23.1 and that C11orf53, C11orf92 and C11orf93 represent novel candidate target genes involved in CRC etiology.
|
24256810 |
2014 |
|
rs3802842
|
COLCA2;COLCA1
|
Rectal Neoplasms
|
|
0.010 |
GeneticVariation |
BEFREE |
Carrying the C allele at rs3802842 appeared to be associated with a lower risk for rectal tumors in our dataset.
|
22457859 |
2012 |
|
rs3802842
|
COLCA2;COLCA1
|
Rectal Diseases
|
|
0.010 |
GeneticVariation |
BEFREE |
Several loci showed statistically significant associations with specific phenotypes notably rs6691170 and rs3802842 associated with microsatellite stable rectal disease; rs4779584, rs961253 and rs4813802 associated with microsatellite stable colonic disease and rs4444235 and rs4925386 with microsatellite instability colonic disease.
|
22045029 |
2012 |
|
rs3802842
|
COLCA2;COLCA1
|
Colonic Diseases
|
|
0.010 |
GeneticVariation |
BEFREE |
Several loci showed statistically significant associations with specific phenotypes notably rs6691170 and rs3802842 associated with microsatellite stable rectal disease; rs4779584, rs961253 and rs4813802 associated with microsatellite stable colonic disease and rs4444235 and rs4925386 with microsatellite instability colonic disease.
|
22045029 |
2012 |
|
rs3802842
|
COLCA2;COLCA1
|
Alcohol or Other Drugs use
|
|
0.010 |
GeneticVariation |
BEFREE |
We used meta-analysis of an efficient empirical-Bayes estimator to detect potential multiplicative interactions between each of the SNPs [rs16892766 at 8q23.3 (EIF3H/UTP23), rs6983267 at 8q24 (MYC), rs10795668 at 10p14 (FLJ3802842), rs3802842 at 11q23 (LOC120376), rs4444235 at 14q22.2 (BMP4), rs4779584 at 15q13 (GREM1), rs9929218 at 16q22.1 (CDH1), rs4939827 at 18q21 (SMAD7), rs10411210 at 19q13.1 (RHPN2), and rs961253 at 20p12.3 (BMP2)] and select major CRC risk factors (sex, body mass index, height, smoking status, aspirin/nonsteroidal anti-inflammatory drug use, alcohol use, and dietary intake of calcium, folate, red meat, processed meat, vegetables, fruit, and fiber).
|
22367214 |
2012 |
|
rs3802842
|
COLCA2;COLCA1
|
Colon Carcinoma
|
|
0.020 |
GeneticVariation |
BEFREE |
A total of 927 MMR gene mutation carriers (360 MLH1, 442 MSH2, 85 MSH6 and 40 PMS2) from 315 families enrolled in the Colon Cancer Family Registry, were genotyped for the single nucleotide polymorphisms (SNPs): rs16892766 (8q23.3), rs6983267 (8q24.21), rs719725 (9p24), rs10795668 (10p14), rs3802842 (11q23.1), rs4444235 (14q22.2), rs4779584 (15q13.3), rs9929218 (16q22.1), rs4939827 (18q21.1), rs10411210 (19q13.1) and rs961253 (20p12.3).
|
23434150 |
2013 |
|
rs3802842
|
COLCA2;COLCA1
|
Rectal Carcinoma
|
|
0.020 |
GeneticVariation |
BEFREE |
At 11q23.1, rs3802842 was significantly associated with rectal cancer risk only among African Americans (odds ratio, 1.34; P = .01); this observation was made in previous studies.
|
20659471 |
2010 |
|
rs3802842
|
COLCA2;COLCA1
|
Rectal Carcinoma
|
|
0.020 |
GeneticVariation |
BEFREE |
Furthermore, we found that rs10795668 was associated with increased risk only in rectal cancer but not colon cancer, and rs3802842 was also significantly associated with advanced stages of CRC.
|
20530476 |
2010 |
|
rs3802842
|
COLCA2;COLCA1
|
Colon Carcinoma
|
|
0.020 |
GeneticVariation |
BEFREE |
Risk was greater for rectal than for colon cancer for rs3802842 (P < 0.008) and rs4939827 (P < 0.009).
|
18372901 |
2008 |
|
rs3802842
|
COLCA2;COLCA1
|
Lynch Syndrome
|
|
0.030 |
GeneticVariation |
BEFREE |
We identified associations at two of the six CRC susceptibility loci in MLH1 mutation carriers from the combined LS cohort: 11q23.1 (rs3802842, HR = 2.68, p ≤ 0.0001) increasing risk of CRC, and rs3802842 in a pair-wise combination with 8q23.3 (rs16892766) affecting age of diagnosis of CRC (log-rank test; p ≤ 0.0001).
|
22987364 |
2013 |
|
rs3802842
|
COLCA2;COLCA1
|
Hereditary Nonpolyposis Colorectal Cancer
|
|
0.030 |
GeneticVariation |
BEFREE |
We identified associations at two of the six CRC susceptibility loci in MLH1 mutation carriers from the combined LS cohort: 11q23.1 (rs3802842, HR = 2.68, p ≤ 0.0001) increasing risk of CRC, and rs3802842 in a pair-wise combination with 8q23.3 (rs16892766) affecting age of diagnosis of CRC (log-rank test; p ≤ 0.0001).
|
22987364 |
2013 |
|
rs3802842
|
COLCA2;COLCA1
|
Lynch Syndrome
|
|
0.030 |
GeneticVariation |
BEFREE |
Regarding early-onset cases, 14q22 (rs4444235), 11q23 (rs3802842) and 20p12 (rs961253) variants were more associated with family history of CRC or tumors of the Lynch syndrome spectrum excluding CRC.
|
22235025 |
2012 |
|
rs3802842
|
COLCA2;COLCA1
|
Hereditary Nonpolyposis Colorectal Cancer
|
|
0.030 |
GeneticVariation |
BEFREE |
Regarding early-onset cases, 14q22 (rs4444235), 11q23 (rs3802842) and 20p12 (rs961253) variants were more associated with family history of CRC or tumors of the Lynch syndrome spectrum excluding CRC.
|
22235025 |
2012 |
|
rs3802842
|
COLCA2;COLCA1
|
Lynch Syndrome
|
|
0.030 |
GeneticVariation |
BEFREE |
Recently, six colorectal cancer (CRC) susceptibility loci have been identified, and two single-nucleotide polymorphisms (SNPs)--rs16892766 (8q23.3) and rs3802842 (11q23.1)--from two of these regions have been found to be significantly associated with an increased CRC risk in patients with Lynch syndrome.
|
21097774 |
2011 |
|
rs3802842
|
COLCA2;COLCA1
|
Hereditary Nonpolyposis Colorectal Cancer
|
|
0.030 |
GeneticVariation |
BEFREE |
Recently, six colorectal cancer (CRC) susceptibility loci have been identified, and two single-nucleotide polymorphisms (SNPs)--rs16892766 (8q23.3) and rs3802842 (11q23.1)--from two of these regions have been found to be significantly associated with an increased CRC risk in patients with Lynch syndrome.
|
21097774 |
2011 |
|
rs3802842
|
COLCA2;COLCA1
|
COLORECTAL CANCER, SUSCEPTIBILITY TO, 1
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Novel Common Genetic Susceptibility Loci for Colorectal Cancer.
|
29917119 |
2019 |
|
rs3802842
|
COLCA2;COLCA1
|
COLORECTAL CANCER, SUSCEPTIBILITY TO, 1
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.
|
30529582 |
2019 |
|
rs3802842
|
COLCA2;COLCA1
|
Adenocarcinoma of large intestine
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.
|
30529582 |
2019 |