COLCA2, colorectal cancer associated 2, 120376

N. diseases: 12; N. variants: 3
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs3802842
rs3802842
Entrez Id: 120376;399948
Gene Symbol: COLCA2;COLCA1
COLCA2;COLCA1
CUI: C2931822
Disease:
Nasopharyngeal carcinoma 		0.700 GeneticVariation GWASDB A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci. 20512145 2010
dbSNP: rs3802842
rs3802842
Entrez Id: 120376;399948
Gene Symbol: COLCA2;COLCA1
COLCA2;COLCA1
CUI: C0009402
Disease:
Colorectal Carcinoma 		0.900 GeneticVariation BEFREE A locus on human chromosome 11q23 tagged by marker rs3802842 was associated with colorectal cancer (CRC) in a genome-wide association study; this finding has been replicated in case-control studies worldwide. 24154973 2014
dbSNP: rs3802842
rs3802842
Entrez Id: 120376;399948
Gene Symbol: COLCA2;COLCA1
COLCA2;COLCA1
CUI: C0009402
Disease:
Colorectal Carcinoma 		0.900 GeneticVariation BEFREE A significant association between the C allele of rs3802842 and CRC risk was found (per allele OR = 1.17; 95% confidence interval [CI]: 1.12-1.22; P = 1.08 x 10(-12)) with the risk allele more frequent in rectal than colonic disease (P = 0.02). 18753146 2008
dbSNP: rs3802842
rs3802842
Entrez Id: 120376;399948
Gene Symbol: COLCA2;COLCA1
COLCA2;COLCA1
CUI: C0007102
Disease:
Malignant tumor of colon 		0.720 GeneticVariation BEFREE A total of 927 MMR gene mutation carriers (360 MLH1, 442 MSH2, 85 MSH6 and 40 PMS2) from 315 families enrolled in the Colon Cancer Family Registry, were genotyped for the single nucleotide polymorphisms (SNPs): rs16892766 (8q23.3), rs6983267 (8q24.21), rs719725 (9p24), rs10795668 (10p14), rs3802842 (11q23.1), rs4444235 (14q22.2), rs4779584 (15q13.3), rs9929218 (16q22.1), rs4939827 (18q21.1), rs10411210 (19q13.1) and rs961253 (20p12.3). 23434150 2013
dbSNP: rs3802842
rs3802842
Entrez Id: 120376;399948
Gene Symbol: COLCA2;COLCA1
COLCA2;COLCA1
CUI: C0699790
Disease:
Colon Carcinoma 		0.020 GeneticVariation BEFREE A total of 927 MMR gene mutation carriers (360 MLH1, 442 MSH2, 85 MSH6 and 40 PMS2) from 315 families enrolled in the Colon Cancer Family Registry, were genotyped for the single nucleotide polymorphisms (SNPs): rs16892766 (8q23.3), rs6983267 (8q24.21), rs719725 (9p24), rs10795668 (10p14), rs3802842 (11q23.1), rs4444235 (14q22.2), rs4779584 (15q13.3), rs9929218 (16q22.1), rs4939827 (18q21.1), rs10411210 (19q13.1) and rs961253 (20p12.3). 23434150 2013
dbSNP: rs3802842
rs3802842
Entrez Id: 120376;399948
Gene Symbol: COLCA2;COLCA1
COLCA2;COLCA1
CUI: C0007113
Disease:
Rectal Carcinoma 		0.020 GeneticVariation BEFREE At 11q23.1, rs3802842 was significantly associated with rectal cancer risk only among African Americans (odds ratio, 1.34; P = .01); this observation was made in previous studies. 20659471 2010
dbSNP: rs3802842
rs3802842
Entrez Id: 120376;399948
Gene Symbol: COLCA2;COLCA1
COLCA2;COLCA1
CUI: C0009402
Disease:
Colorectal Carcinoma 		0.900 GeneticVariation BEFREE Based on χ(2) tests, PLCE1 -rs2077218, rs11187877 (p = 0.049) and C11orf92-C11orf93-rs3802842 (p = 0.023) correlate with C</span>RC risk. 24146276 2014
dbSNP: rs3802842
rs3802842
Entrez Id: 120376;399948
Gene Symbol: COLCA2;COLCA1
COLCA2;COLCA1
CUI: C0034885
Disease:
Rectal Neoplasms 		0.010 GeneticVariation BEFREE Carrying the C allele at rs3802842 appeared to be associated with a lower risk for rectal tumors in our dataset. 22457859 2012
dbSNP: rs3802842
rs3802842
Entrez Id: 120376;399948
Gene Symbol: COLCA2;COLCA1
COLCA2;COLCA1
CUI: C0009402
Disease:
Colorectal Carcinoma 		0.900 GeneticVariation BEFREE Common genetic variant rs3802842 in 11q23 contributes to colorectal cancer risk in Chinese population. 29069782 2017
dbSNP: rs3802842
rs3802842
Entrez Id: 120376;399948
Gene Symbol: COLCA2;COLCA1
COLCA2;COLCA1
CUI: C4722085
Disease:
Malignant neoplasm of colon and/or rectum 		0.010 GeneticVariation BEFREE Common genetic variant rs3802842 in 11q23 contributes to colorectal cancer risk in Chinese population. 29069782 2017
dbSNP: rs3802842
rs3802842
Entrez Id: 120376;399948
Gene Symbol: COLCA2;COLCA1
COLCA2;COLCA1
CUI: C0009402
Disease:
Colorectal Carcinoma 		0.900 GeneticVariation BEFREE Female MLH1 mutation carriers harbouring the homozygous variant genotype for SNP rs3802842 have the highest risk of developing CRC. 21097774 2011
dbSNP: rs3802842
rs3802842
Entrez Id: 120376;399948
Gene Symbol: COLCA2;COLCA1
COLCA2;COLCA1
CUI: C0009402
Disease:
Colorectal Carcinoma 		0.900 GeneticVariation BEFREE For rs3802842, the increased risk of CRC associated with the C-allele was only found among female carriers, while CRC risk was substantially higher among homozygous (hazard ratio [HR] 3.08) than among heterozygous carriers of the C-allele (HR 1.49). 19010329 2009
dbSNP: rs3802842
rs3802842
Entrez Id: 120376;399948
Gene Symbol: COLCA2;COLCA1
COLCA2;COLCA1
CUI: C0007113
Disease:
Rectal Carcinoma 		0.020 GeneticVariation BEFREE Furthermore, we found that rs10795668 was associated with increased risk only in rectal cancer but not colon cancer, and rs3802842 was also significantly associated with advanced stages of CRC. 20530476 2010
dbSNP: rs3802842
rs3802842
Entrez Id: 120376;399948
Gene Symbol: COLCA2;COLCA1
COLCA2;COLCA1
CUI: C0009402
Disease:
Colorectal Carcinoma 		C 0.900 GeneticVariation GWASCAT Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. 18372901 2008
dbSNP: rs3802842
rs3802842
Entrez Id: 120376;399948
Gene Symbol: COLCA2;COLCA1
COLCA2;COLCA1
CUI: C0009402
Disease:
Colorectal Carcinoma 		C 0.900 GeneticVariation GWASDB Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. 18372901 2008
dbSNP: rs3802842
rs3802842
Entrez Id: 120376;399948
Gene Symbol: COLCA2;COLCA1
COLCA2;COLCA1
CUI: C0009404
Disease:
Colorectal Neoplasms 		C 0.700 GeneticVariation GWASCAT Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. 18372901 2008
dbSNP: rs3802842
rs3802842
Entrez Id: 120376;399948
Gene Symbol: COLCA2;COLCA1
COLCA2;COLCA1
CUI: C3554460
Disease:
COLORECTAL CANCER, SUSCEPTIBILITY TO, 12 		C 0.700 GeneticVariation GWASCAT Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. 18372901 2008
dbSNP: rs3802842
rs3802842
Entrez Id: 120376;399948
Gene Symbol: COLCA2;COLCA1
COLCA2;COLCA1
CUI: C0346629
Disease:
Malignant neoplasm of large intestine 		C 0.700 GeneticVariation GWASCAT Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. 18372901 2008
dbSNP: rs3802842
rs3802842
Entrez Id: 120376;399948
Gene Symbol: COLCA2;COLCA1
COLCA2;COLCA1
CUI: C1319315
Disease:
Adenocarcinoma of large intestine 		C 0.700 GeneticVariation GWASCAT Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. 18372901 2008
dbSNP: rs3802842
rs3802842
Entrez Id: 120376;399948
Gene Symbol: COLCA2;COLCA1
COLCA2;COLCA1
CUI: C2675481
Disease:
COLORECTAL CANCER, SUSCEPTIBILITY TO, 10 		C 0.700 GeneticVariation GWASCAT Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. 18372901 2008
dbSNP: rs3802842
rs3802842
Entrez Id: 120376;399948
Gene Symbol: COLCA2;COLCA1
COLCA2;COLCA1
CUI: C2677123
Disease:
COLORECTAL CANCER, SUSCEPTIBILITY TO, 3 		C 0.700 GeneticVariation GWASCAT Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. 18372901 2008
dbSNP: rs3802842
rs3802842
Entrez Id: 120376;399948
Gene Symbol: COLCA2;COLCA1
COLCA2;COLCA1
CUI: C1837315
Disease:
COLORECTAL CANCER, SUSCEPTIBILITY TO, 1 		C 0.700 GeneticVariation GWASCAT Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. 18372901 2008
dbSNP: rs3802842
rs3802842
Entrez Id: 120376;399948
Gene Symbol: COLCA2;COLCA1
COLCA2;COLCA1
CUI: C0009402
Disease:
Colorectal Carcinoma 		0.900 GeneticVariation BEFREE Genome-wide association studies of colorectal cancer (CRC) have identified a number of common variants associated with modest risk, including rs3802842 at chromosome 11q23.1. 24256810 2014
dbSNP: rs6589219
rs6589219
Entrez Id: 120376;399948
Gene Symbol: COLCA2;COLCA1
COLCA2;COLCA1
CUI: C2675481
Disease:
COLORECTAL CANCER, SUSCEPTIBILITY TO, 10 		G 0.700 GeneticVariation GWASCAT Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci. 28960316 2018
dbSNP: rs6589219
rs6589219
Entrez Id: 120376;399948
Gene Symbol: COLCA2;COLCA1
COLCA2;COLCA1
CUI: C0009402
Disease:
Colorectal Carcinoma 		G 0.700 GeneticVariation GWASCAT Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci. 28960316 2018