|
rs2298383
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Depressive episode, unspecified
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, we examined an association between a single nucleotide polymorphism in A<sub>2A</sub> receptor gene (ADORA2A, rs2298383 SNP) with current depressive episode and symptom profile.
|
30511252 |
2019 |
|
rs2298383
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Mental Depression
|
|
0.010 |
GeneticVariation |
BEFREE |
Our data support an important role for ADORA2A rs2298383 SNP in clinical heterogeneity associated with depression.
|
30511252 |
2019 |
|
rs2298383
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Rheumatoid Arthritis
|
|
0.010 |
GeneticVariation |
BEFREE |
The combination of MTHFR 1298AA along with ADORA2A rs2298383 CC or CT genotypes occurring in one-third of RA patients showed a higher frequency of general nodules 15/59 (25.4%) as well as developing nodules during MTX treatment 13/59 (22.0%) in comparison with the overall studied group: 24/185 (13.0%) and 19/185 (10.3%), respectively.
|
27846189 |
2017 |
|
rs2298383
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Leukoencephalopathy
|
|
0.010 |
GeneticVariation |
BEFREE |
ADORA2A rs2298383 and high cumulative dose of systemic MTX administration were significantly associated with MTX-related leukoencephalopathy.
|
27399166 |
2016 |
|
rs2298383
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Akathisia
|
|
0.010 |
GeneticVariation |
BEFREE |
We found an association between ADORA1 rs3766566 and psychopathological symptoms (p = 0.006), in particular, with positive psychopathological symptoms (p = 0.010) and general psychopathological symptoms (p = 0.023), between ADORA2A rs2298383 and general psychopathological symptoms (p = 0.046), and between ADORA2A rs5751876 and akathisia (p = 0.015).
|
27195966 |
2016 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Familial neurocardiogenic syncope
|
|
0.010 |
GeneticVariation |
BEFREE |
Adenosine A(2A) receptor 1083 T > C polymorphism is not associated with the positivity of HUT and its proposed role in predisposition to VVS was not confirmed.
|
26710963 |
2016 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Akathisia
|
|
0.010 |
GeneticVariation |
BEFREE |
We found an association between ADORA1 rs3766566 and psychopathological symptoms (p = 0.006), in particular, with positive psychopathological symptoms (p = 0.010) and general psychopathological symptoms (p = 0.023), between ADORA2A rs2298383 and general psychopathological symptoms (p = 0.046), and between ADORA2A rs5751876 and akathisia (p = 0.015).
|
27195966 |
2016 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Syncope
|
|
0.010 |
GeneticVariation |
BEFREE |
One thousand and eighty-three T > C single nucleotide polymorphism in the adenosine A(2A) receptor gene (rs5751876) was evaluated in 347 patients with syncope and in 85 subjects without history of syncope (54 men, mean age 41.7 ± 16.3).
|
26710963 |
2016 |
|
rs4822489
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Congestive heart failure
|
|
0.010 |
GeneticVariation |
BEFREE |
The findings of this study suggest that rs4822489 may contribute to the severity of CHF in the northern Chinese.
|
25629231 |
2015 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Gilles de la Tourette syndrome
|
|
0.010 |
GeneticVariation |
BEFREE |
The minor allele T frequency of rs5751876 was lower in GTS patients with </span>co-morbid attention deficit hyperactivity disorder (p = 0.022), and TT+TC genotypes were less frequent in the non-OCD anxiety disorder group (p = 0.045).
|
26317759 |
2015 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Malaria
|
|
0.010 |
GeneticVariation |
BEFREE |
Single-locus analysis showed significant association of 2 SNPs; rs5751876 (OR=3.2(2.0-5.2); p=0.0006) of ADORA2A and rs2230345 (OR=0.3(0.2-0.5); p=0.0006) of GRK5 with malaria.
|
26066465 |
2015 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Attention deficit hyperactivity disorder
|
|
0.010 |
GeneticVariation |
BEFREE |
The minor allele T frequency of rs5751876 was lower in GTS patients with co-morbid attention deficit hyperactivity disorder (p = 0.022), and TT+TC genotypes were less frequent in the non-OCD anxiety disorder group (p = 0.045).
|
26317759 |
2015 |
|
rs9624472
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Malaria
|
|
0.010 |
GeneticVariation |
BEFREE |
The mean of the serum creatinine levels were significantly higher in patients with variant GG (p=0.006) of rs9624472 in ADORA2A gene compared to AA and AG genotypes in complicated Pf malaria cases, with the G allele also showing increased risk for malaria (OR=1.3(1.1-1.6); p=0.017).
|
26066465 |
2015 |
|
rs35320474
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Apnea
|
|
0.010 |
GeneticVariation |
BEFREE |
Logistic regression analysis showed a significant correlation between rs35320474-C/T and T/T genotypes and apnoea and BPD development.
|
22462821 |
2012 |
|
rs35320474
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Bronchopulmonary Dysplasia
|
|
0.010 |
GeneticVariation |
BEFREE |
Logistic regression analysis showed a significant correlation between rs35320474-C/T and T/T genotypes and apnoea and BPD development.
|
22462821 |
2012 |
|
rs2236624
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
PIGMENTARY DISORDER, RETICULATE, WITH SYSTEMIC MANIFESTATIONS
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant association was observed between SNP rs2236624 and PDR in the recessive genetic model.
|
21088442 |
2011 |
|
rs4822489
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
PIGMENTARY DISORDER, RETICULATE, WITH SYSTEMIC MANIFESTATIONS
|
|
0.010 |
GeneticVariation |
BEFREE |
Similarly, for SNP rs4822489, an association between PDR and T allele homozygosity was observed following covariate adjustment (OR = 0.55; 95% CI: 0.31-0.92; p = 0.04).
|
21088442 |
2011 |
|
rs5751876
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Severe myopia
|
|
0.010 |
GeneticVariation |
BEFREE |
The reduced frequency of the heterozygote rs5751876 genotype in subjects suggests a possible association of A(2A)R with high myopia in a Chinese population.
|
22740769 |
2011 |
|
rs5996696
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Parkinson Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
Two ADORA2A polymorphisms were inversely associated with PD risk - rs71651683, a 5' variant (adjusted allelic OR = 0.51, 95% CI 0.33-0.80, permutation-adjusted P = 0.015) and rs5996696, a promoter region variant (adjusted OR for AC and CC genotypes compared with the AA wild-type genotype were 0.76 (95% CI 0.57-1.02) and 0.37 (95% CI 0.13-1.01), respectively (permutation-adjusted P for trend = 0.04).
|
21281405 |
2011 |
|
rs71651683
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Parkinson Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
Two ADORA2A polymorphisms were inversely associated with PD risk - rs71651683, a 5' variant (adjusted allelic OR = 0.51, 95% CI 0.33-0.80, permutation-adjusted P = 0.015) and rs5996696, a promoter region variant (adjusted OR for AC and CC genotypes compared with the AA wild-type genotype were 0.76 (95% CI 0.57-1.02) and 0.37 (95% CI 0.13-1.01), respectively (permutation-adjusted P for trend = 0.04).
|
21281405 |
2011 |
|
rs2236624
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Autism Spectrum Disorders
|
|
0.010 |
GeneticVariation |
BEFREE |
Nominal association with the disorder was observed for rs2236624-CC, and phenotypic variability in ASD symptoms was influenced by rs3761422, rs5751876 and rs35320474.
|
19565319 |
2010 |
|
rs3761422
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Caffeine related disorders
|
|
0.010 |
GeneticVariation |
BEFREE |
Apart from the almost completely linked ADORA2A SNP rs3761422, no other of eight ADORA2A and seven ADORA1 SNPs studied were found to be clearly associated with effects of caffeine on anxiety, alertness, or headache.
|
20520601 |
2010 |
|
rs3761422
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Anxiety
|
|
0.010 |
GeneticVariation |
BEFREE |
Apart from the almost completely linked ADORA2A SNP rs3761422, no other of eight ADORA2A and seven ADORA1 SNPs studied were found to be clearly associated with effects of caffeine on anxiety, alertness, or headache.
|
20520601 |
2010 |
|
rs3761422
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Headache
|
|
0.010 |
GeneticVariation |
BEFREE |
Apart from the almost completely linked ADORA2A SNP rs3761422, no other of eight ADORA2A and seven ADORA1 SNPs studied were found to be clearly associated with effects of caffeine on anxiety, alertness, or headache.
|
20520601 |
2010 |
|
rs3761422
|
ADORA2A;ADORA2A-AS1;SPECC1L-ADORA2A
|
Anxiety Disorders
|
|
0.010 |
GeneticVariation |
BEFREE |
Apart from the almost completely linked ADORA2A SNP rs3761422, no other of eight ADORA2A and seven ADORA1 SNPs studied were found to be clearly associated with effects of caffeine on anxiety, alertness, or headache.
|
20520601 |
2010 |