rs11865121
×
Entrez Id:
23274
Gene Symbol:
CLEC16A
CLEC16A
Multiple Sclerosis
C
0.800
GeneticVariation
GWASCAT
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.
19525953
2009
rs11865121
×
Entrez Id:
23274
Gene Symbol:
CLEC16A
CLEC16A
Multiple Sclerosis
C
0.800
GeneticVariation
GWASDB
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.
19525953
2009
rs11860603
×
Entrez Id:
23274
Gene Symbol:
CLEC16A
CLEC16A
Multiple Sclerosis
0.700
GeneticVariation
GWASDB
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.
19525953
2009
rs7184083
CLEC16A;LOC105371081
Multiple Sclerosis
0.700
GeneticVariation
GWASDB
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.
19525953
2009
rs6498169
×
Entrez Id:
23274
Gene Symbol:
CLEC16A
CLEC16A
Multiple Sclerosis
0.030
GeneticVariation
BEFREE
Independent genome-wide association studies highlighted the function of CLEC16A/KIAA0350 polymorphisms modifying the risk to either multiple sclerosis (rs6498169 ) or type 1 diabetes (rs2903692).
19337309
2009
rs725613
×
Entrez Id:
23274
Gene Symbol:
CLEC16A
CLEC16A
Multiple Sclerosis
0.020
GeneticVariation
BEFREE
In these Sardinian samples, allele A of rs725613 is positively associated not only with T1D (odds ratio=1.15, P one-tail=5.1 x 10(-3)) but also, and with a comparable effect size, with MS (odds ratio=1.21, P one-tail 6.7 x 10(-5)).
18946483
2009
rs2903692
×
Entrez Id:
23274
Gene Symbol:
CLEC16A
CLEC16A
Multiple Sclerosis
0.010
GeneticVariation
BEFREE
Independent genome-wide association studies highlighted the function of CLEC16A/KIAA0350 polymorphisms modifying the risk to either multiple sclerosis (rs6498169) or type 1 diabetes (rs2903692 ).
19337309
2009
rs6498169
×
Entrez Id:
23274
Gene Symbol:
CLEC16A
CLEC16A
Multiple Sclerosis
0.030
GeneticVariation
BEFREE
The described association of rs6498169 with MS was replicated in MS and RA cohorts.
19221398
2010
rs1465201414
×
Entrez Id:
23274
Gene Symbol:
CLEC16A
CLEC16A
Multiple Sclerosis
0.010
GeneticVariation
BEFREE
Rs4774 (missense +1614G/C; G500A ) was associated with MS (P = 4.9 x 10(-3)), particularly in DRB1*1501 +individuals (P = 1 x 10(-4)).
20211854
2010
rs7200786
×
Entrez Id:
23274
Gene Symbol:
CLEC16A
CLEC16A
Multiple Sclerosis
A
0.800
GeneticVariation
GWASDB
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
21833088
2011
rs7200786
×
Entrez Id:
23274
Gene Symbol:
CLEC16A
CLEC16A
Multiple Sclerosis
A
0.800
GeneticVariation
GWASCAT
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
21833088
2011
rs12708716
×
Entrez Id:
23274
Gene Symbol:
CLEC16A
CLEC16A
Multiple Sclerosis
0.710
GeneticVariation
GWASDB
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
21833088
2011
rs12708716
×
Entrez Id:
23274
Gene Symbol:
CLEC16A
CLEC16A
Multiple Sclerosis
0.710
GeneticVariation
BEFREE
In combined analyses, SNP rs12708716 gave the strongest association signal in MS (P=5.3 x 10⁻⁸, odds ratio 1.18, 95% confidence interval=1.11-1.25), and was found to be superior to the other SNP associations in conditional logistic regression analyses.
21179112
2011
rs725613
×
Entrez Id:
23274
Gene Symbol:
CLEC16A
CLEC16A
Multiple Sclerosis
0.020
GeneticVariation
BEFREE
We could replicate the finding for SNP rs725613 and were able to show for the first time the association of rs2041670, rs2080272 and rs998592 with MS .
20849399
2011
rs2041670
×
Entrez Id:
23274
Gene Symbol:
CLEC16A
CLEC16A
Multiple Sclerosis
0.010
GeneticVariation
BEFREE
We could replicate the finding for SNP rs725613 and were able to show for the first time the association of rs2041670 , rs2080272 and rs998592 with MS .
20849399
2011
rs2080272
×
Entrez Id:
23274
Gene Symbol:
CLEC16A
CLEC16A
Multiple Sclerosis
0.010
GeneticVariation
BEFREE
We could replicate the finding for SNP rs725613 and were able to show for the first time the association of rs2041670, rs2080272 and rs998592 with MS .
20849399
2011
rs998592
×
Entrez Id:
23274
Gene Symbol:
CLEC16A
CLEC16A
Multiple Sclerosis
0.010
GeneticVariation
BEFREE
We could replicate the finding for SNP rs725613 and were able to show for the first time the association of rs2041670, rs2080272 and rs998592 with MS .
20849399
2011
rs6498169
×
Entrez Id:
23274
Gene Symbol:
CLEC16A
CLEC16A
Multiple Sclerosis
0.030
GeneticVariation
BEFREE
Association of SNPs rs6498169 and rs10984447 with multiple sclerosis in Saudi patients: a model of the usefulness of familial aggregates in identifying genetic linkage in a multifactorial disease.
22492128
2012
rs12927355
×
Entrez Id:
23274
Gene Symbol:
CLEC16A
CLEC16A
Multiple Sclerosis
G
0.700
GeneticVariation
GWASCAT
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.
24076602
2013
rs6498168
×
Entrez Id:
23274
Gene Symbol:
CLEC16A
CLEC16A
Multiple Sclerosis
T
0.700
GeneticVariation
GWASCAT
Novel multiple sclerosis susceptibility loci implicated in epigenetic regulation.
27386562
2016
rs6498160
×
Entrez Id:
23274
Gene Symbol:
CLEC16A
CLEC16A
Multiple Sclerosis
T
0.700
GeneticVariation
GWASCAT
Overexpression of the Cytokine BAFF and Autoimmunity Risk.
28445677
2017
rs8056098
×
Entrez Id:
23274
Gene Symbol:
CLEC16A
CLEC16A
Multiple Sclerosis
0.010
GeneticVariation
BEFREE
Three SNPs linked to MS clinical severity showed a significant association between the genotype and either the proportion of active lesions (rs2234978/FAS and rs11957313/KCNIP1) or the proportion of mixed active/inactive lesions (rs8056098 /CLEC16A).
31228212
2020