|
rs137853247
|
HNF1A;HNF1A-AS1
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs137853247
|
HNF1A;HNF1A-AS1
|
MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 3 (disorder)
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs137853247
|
HNF1A;HNF1A-AS1
|
Chromophobe Renal Cell Carcinoma
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs1566092470
|
HNF1A;HNF1A-AS1
|
DIABETES MELLITUS, INSULIN-DEPENDENT, 20 (disorder)
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs193922578
|
HNF1A;HNF1A-AS1
|
MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 3 (disorder)
|
G |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs193922588
|
HNF1A;HNF1A-AS1
|
MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 3 (disorder)
|
G |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs193922592
|
HNF1A;HNF1A-AS1
|
MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 3 (disorder)
|
G |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs193922593
|
HNF1A;HNF1A-AS1
|
MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 3 (disorder)
|
T |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs193922594
|
HNF1A;HNF1A-AS1
|
MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 3 (disorder)
|
TG |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs774637975
|
HNF1A;HNF1A-AS1
|
MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 3 (disorder)
|
T |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs1169288
|
HNF1A;HNF1A-AS1
|
Ischemic stroke
|
|
0.020 |
GeneticVariation |
BEFREE |
<b>Results</b>: Three out of 10 eligible SNPs were shown to be associated with risk of ischemic stroke. rs1800947 in <i>CRP</i> gene (additive model: OR = 2.08, 95% CI: 1.00-4.23) and rs1169288 in <i>HNF1A</i> gene (additive model: OR = 1.45, 95% CI: 1.03-2.06) were associated with an increased risk of ischemic stroke. rs440446 in <i>APOE</i> gene (additive model: OR = 0.63, 95%CI: 0.44-0.88) was associated with a decreased risk of ischemic stroke.
|
31584351 |
2019 |
|
rs1169288
|
HNF1A;HNF1A-AS1
|
Hypertriglyceridemia
|
|
0.010 |
GeneticVariation |
BEFREE |
I27L showed "protective effect" upon hypertriglyceridemia in this sample of individuals, suggesting a role for HNF1A on diabetic individuals' lipid profile.
|
19490620 |
2009 |
|
rs7305618
|
HNF1A-AS1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.810 |
GeneticVariation |
BEFREE |
rs7305618 and rs8078723 were associated with the risk of T2DM in a Chinese population and were modulated by erythrocyte PL fatty acids composition.
|
25969153 |
2014 |
|
rs142318174
|
HNF1A;HNF1A-AS1
|
Diabetes
|
|
0.010 |
GeneticVariation |
BEFREE |
A 5-nucleotide insertion in intron 1 was present in both diabetic members of a small family, but Gly52Ala, Gly574Ser, and the intron 10 mutation did not segregate with diabetes.
|
10690959 |
2000 |
|
rs142318174
|
HNF1A;HNF1A-AS1
|
Diabetes Mellitus
|
|
0.010 |
GeneticVariation |
BEFREE |
A 5-nucleotide insertion in intron 1 was present in both diabetic members of a small family, but Gly52Ala, Gly574Ser, and the intron 10 mutation did not segregate with diabetes.
|
10690959 |
2000 |
|
rs587778393
|
HNF1A;HNF1A-AS1
|
Diabetes Mellitus
|
|
0.010 |
GeneticVariation |
BEFREE |
A 5-nucleotide insertion in intron 1 was present in both diabetic members of a small family, but Gly52Ala, Gly574Ser, and the intron 10 mutation did not segregate with diabetes.
|
10690959 |
2000 |
|
rs587778393
|
HNF1A;HNF1A-AS1
|
Diabetes
|
|
0.010 |
GeneticVariation |
BEFREE |
A 5-nucleotide insertion in intron 1 was present in both diabetic members of a small family, but Gly52Ala, Gly574Ser, and the intron 10 mutation did not segregate with diabetes.
|
10690959 |
2000 |
|
rs1169288
|
HNF1A;HNF1A-AS1
|
Serum total cholesterol measurement
|
A |
0.800 |
GeneticVariation |
GWASCAT |
A large electronic-health-record-based genome-wide study of serum lipids.
|
29507422 |
2018 |
|
rs1169288
|
HNF1A;HNF1A-AS1
|
Low density lipoprotein cholesterol measurement
|
A |
0.800 |
GeneticVariation |
GWASCAT |
A large electronic-health-record-based genome-wide study of serum lipids.
|
29507422 |
2018 |
|
rs1169288
|
HNF1A;HNF1A-AS1
|
Maturity onset diabetes mellitus in young
|
|
0.030 |
GeneticVariation |
BEFREE |
A new mutation in the hepatocyte nuclear factor-1-alpha gene (P224S) in a newly discovered German family with maturity-onset diabetes of the young 3 (MODY 3). Family members carry additionally the homozygous I27L amino acid polymorphism in the HNF1 alpha gene.
|
15031772 |
2004 |
|
rs7305618
|
HNF1A-AS1
|
Polycystic Ovary Syndrome
|
|
0.010 |
GeneticVariation |
BEFREE |
A total of 310 family trios were studied and the transmission disequilibrium test (TDT) was used to assess the linkage between PCOS and three single-nucleotide polymorphisms (SNP) (rs4820599 of GGT1, rs7305618 and rs2393791 of HNF1A).No deviations from HWE were detected.
|
29169850 |
2018 |
|
rs1388926124
|
HNF1A;HNF1A-AS1
|
Diabetes Mellitus
|
|
0.010 |
GeneticVariation |
BEFREE |
Although the E23K variant rs5219 in KCNJ11 showed no association with diabetes in Japanese (for the K allele, odds ratio [OR] 1.08 [95% CI 0.97-1.21], P = 0.15), 95% CI around the OR overlaps in meta-analysis of European populations, suggesting that our results are not inconsistent with the previous studies.
|
16873704 |
2006 |
|
rs1388926124
|
HNF1A;HNF1A-AS1
|
Diabetes
|
|
0.010 |
GeneticVariation |
BEFREE |
Although the E23K variant rs5219 in KCNJ11 showed no association with diabetes in Japanese (for the K allele, odds ratio [OR] 1.08 [95% CI 0.97-1.21], P = 0.15), 95% CI around the OR overlaps in meta-analysis of European populations, suggesting that our results are not inconsistent with the previous studies.
|
16873704 |
2006 |
|
rs1169288
|
HNF1A;HNF1A-AS1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.780 |
GeneticVariation |
BEFREE |
Amongst non-obese individuals, we observed significant T2D associations with HNF1A I27L [odds ratio (OR) = 1.14, P = 0.04], GCK -30G>A (OR = 1.23, P = 0.01), SLC30A8 R325W (OR = 0.87, P = 0.04), and TCF7L2 rs7903146 (OR = 1.89, P = 4.5 x 10-23), and non-significant associations with PPARG Pro12Ala (OR = 0.85, P = 0.14), ADIPOQ -11,377C>G (OR = 1.00, P = 0.97) and ENPP1 K121Q (OR = 0.99, P = 0.94).
|
18498634 |
2008 |
|
rs2650000
|
HNF1A-AS1
|
C-reactive protein measurement
|
C |
0.800 |
GeneticVariation |
GWASDB |
Are C-reactive protein associated genetic variants associated with serum levels and retinal markers of microvascular pathology in Asian populations from Singapore?
|
23844046 |
2013 |