HNF1A-AS1, HNF1A antisense RNA 1, 283460

N. diseases: 70; N. variants: 31
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1800574
rs1800574
Entrez Id: 6927;283460
Gene Symbol: HNF1A;HNF1A-AS1
HNF1A;HNF1A-AS1
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.850 GeneticVariation BEFREE We hypothesized that common variants at the <i>HNF1A</i> locus (rs1169288 [I27L], rs1800574 [A98V]), which are associated with type 2 diabetes susceptibility, may modify age at diabetes diagnosis in individuals with HNF1A-MODY. 29895593 2018
dbSNP: rs1800574
rs1800574
Entrez Id: 6927;283460
Gene Symbol: HNF1A;HNF1A-AS1
HNF1A;HNF1A-AS1
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		T 0.850 GeneticVariation GWASCAT Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes. 29632382 2018
dbSNP: rs1800574
rs1800574
Entrez Id: 6927;283460
Gene Symbol: HNF1A;HNF1A-AS1
HNF1A;HNF1A-AS1
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.850 GeneticVariation BEFREE The common variants p.I27L (rs1169288), p.A98V (rs1800574) and p.S487N (rs2464196) of the hepatocyte nuclear factor 1-α (HNF1A) gene have been inconsistently associated with impaired glucose tolerance and/or an increased risk of type 2 diabetes mellitus (T2DM). 24933231 2015
dbSNP: rs1800574
rs1800574
Entrez Id: 6927;283460
Gene Symbol: HNF1A;HNF1A-AS1
HNF1A;HNF1A-AS1
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.850 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. 22325160 2012
dbSNP: rs1800574
rs1800574
Entrez Id: 6927;283460
Gene Symbol: HNF1A;HNF1A-AS1
HNF1A;HNF1A-AS1
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.850 GeneticVariation BEFREE Significant associations between the heterozygote A98V genotype and clinical parameters of insulin metabolism were reported but no relationship with type 2 diabetes was obtained. 18777455 2008
dbSNP: rs1800574
rs1800574
Entrez Id: 6927;283460
Gene Symbol: HNF1A;HNF1A-AS1
HNF1A;HNF1A-AS1
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.850 GeneticVariation BEFREE We studied the effect of four common polymorphisms (rs1920792, I27L, A98V and S487N) in and upstream of the HNF-1alpha gene on transcriptional activity in vitro, and their possible association with type 2 diabetes and insulin secretion in vivo. 17033837 2006
dbSNP: rs1800574
rs1800574
Entrez Id: 6927;283460
Gene Symbol: HNF1A;HNF1A-AS1
HNF1A;HNF1A-AS1
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.850 GeneticVariation BEFREE Polymorphisms of these genes (Ala45Thr [NEUROD1], Ser199Phe [NEUROG3], and Ala98Val [TCF1]) have been postulated to influence the development of type 2 diabetes. 15277395 2004
dbSNP: rs7305618
rs7305618
Entrez Id: 283460
Gene Symbol: HNF1A-AS1
HNF1A-AS1
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.810 GeneticVariation BEFREE rs7305618 and rs8078723 were associated with the risk of T2DM in a Chinese population and were modulated by erythrocyte PL fatty acids composition. 25969153 2014
dbSNP: rs7305618
rs7305618
Entrez Id: 283460
Gene Symbol: HNF1A-AS1
HNF1A-AS1
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		C 0.810 GeneticVariation GWASCAT Genome-wide association study of type 2 diabetes in a sample from Mexico City and a meta-analysis of a Mexican-American sample from Starr County, Texas. 21573907 2011
dbSNP: rs7305618
rs7305618
Entrez Id: 283460
Gene Symbol: HNF1A-AS1
HNF1A-AS1
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		C 0.810 GeneticVariation GWASDB Genome-wide association study of type 2 diabetes in a sample from Mexico City and a meta-analysis of a Mexican-American sample from Starr County, Texas. 21573907 2011
dbSNP: rs1169288
rs1169288
Entrez Id: 6927;283460
Gene Symbol: HNF1A;HNF1A-AS1
HNF1A;HNF1A-AS1
CUI: C0202117
Disease:
Low density lipoprotein cholesterol measurement 		0.800 GeneticVariation GWASCAT Genetic analyses of diverse populations improves discovery for complex traits. 31217584 2019
dbSNP: rs1169288
rs1169288
Entrez Id: 6927;283460
Gene Symbol: HNF1A;HNF1A-AS1
HNF1A;HNF1A-AS1
CUI: C0202117
Disease:
Low density lipoprotein cholesterol measurement 		A 0.800 GeneticVariation GWASCAT Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. 30926973 2019
dbSNP: rs2650000
rs2650000
Entrez Id: 283460
Gene Symbol: HNF1A-AS1
HNF1A-AS1
CUI: C0201657
Disease:
C-reactive protein measurement 		0.800 GeneticVariation GWASCAT Genetic analyses of diverse populations improves discovery for complex traits. 31217584 2019
dbSNP: rs7305618
rs7305618
Entrez Id: 283460
Gene Symbol: HNF1A-AS1
HNF1A-AS1
CUI: C0201657
Disease:
C-reactive protein measurement 		0.800 GeneticVariation GWASCAT Genetic analyses of diverse populations improves discovery for complex traits. 31217584 2019
dbSNP: rs7953249
rs7953249
Entrez Id: 283460
Gene Symbol: HNF1A-AS1
HNF1A-AS1
CUI: C0201657
Disease:
C-reactive protein measurement 		0.800 GeneticVariation GWASCAT Genetic analyses of diverse populations improves discovery for complex traits. 31217584 2019
dbSNP: rs1169288
rs1169288
Entrez Id: 6927;283460
Gene Symbol: HNF1A;HNF1A-AS1
HNF1A;HNF1A-AS1
CUI: C0202117
Disease:
Low density lipoprotein cholesterol measurement 		A 0.800 GeneticVariation GWASCAT Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program. 30275531 2018
dbSNP: rs1169288
rs1169288
Entrez Id: 6927;283460
Gene Symbol: HNF1A;HNF1A-AS1
HNF1A;HNF1A-AS1
CUI: C1445957
Disease:
Serum total cholesterol measurement 		A 0.800 GeneticVariation GWASCAT A large electronic-health-record-based genome-wide study of serum lipids. 29507422 2018
dbSNP: rs1169288
rs1169288
Entrez Id: 6927;283460
Gene Symbol: HNF1A;HNF1A-AS1
HNF1A;HNF1A-AS1
CUI: C0202117
Disease:
Low density lipoprotein cholesterol measurement 		A 0.800 GeneticVariation GWASCAT A large electronic-health-record-based genome-wide study of serum lipids. 29507422 2018
dbSNP: rs1169288
rs1169288
Entrez Id: 6927;283460
Gene Symbol: HNF1A;HNF1A-AS1
HNF1A;HNF1A-AS1
CUI: C1445957
Disease:
Serum total cholesterol measurement 		A 0.800 GeneticVariation GWASCAT Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program. 30275531 2018
dbSNP: rs1169288
rs1169288
Entrez Id: 6927;283460
Gene Symbol: HNF1A;HNF1A-AS1
HNF1A;HNF1A-AS1
CUI: C0202117
Disease:
Low density lipoprotein cholesterol measurement 		A 0.800 GeneticVariation GWASCAT Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels. 28334899 2017
dbSNP: rs2244608
rs2244608
Entrez Id: 6927;283460
Gene Symbol: HNF1A;HNF1A-AS1
HNF1A;HNF1A-AS1
CUI: C1445957
Disease:
Serum total cholesterol measurement 		A 0.800 GeneticVariation GWASCAT Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels. 28334899 2017
dbSNP: rs7305618
rs7305618
Entrez Id: 283460
Gene Symbol: HNF1A-AS1
HNF1A-AS1
CUI: C0201657
Disease:
C-reactive protein measurement 		T 0.800 GeneticVariation GWASDB New variants including ARG1 polymorphisms associated with C-reactive protein levels identified by genome-wide association and pathway analysis. 24763700 2014
dbSNP: rs7953249
rs7953249
Entrez Id: 283460
Gene Symbol: HNF1A-AS1
HNF1A-AS1
CUI: C0201657
Disease:
C-reactive protein measurement 		A 0.800 GeneticVariation GWASDB New variants including ARG1 polymorphisms associated with C-reactive protein levels identified by genome-wide association and pathway analysis. 24763700 2014
dbSNP: rs1169288
rs1169288
Entrez Id: 6927;283460
Gene Symbol: HNF1A;HNF1A-AS1
HNF1A;HNF1A-AS1
CUI: C0202117
Disease:
Low density lipoprotein cholesterol measurement 		C 0.800 GeneticVariation GWASCAT Discovery and refinement of loci associated with lipid levels. 24097068 2013
dbSNP: rs1169288
rs1169288
Entrez Id: 6927;283460
Gene Symbol: HNF1A;HNF1A-AS1
HNF1A;HNF1A-AS1
CUI: C1445957
Disease:
Serum total cholesterol measurement 		C 0.800 GeneticVariation GWASDB Discovery and refinement of loci associated with lipid levels. 24097068 2013