|
rs1054762079
|
HNF1A;HNF1A-AS1
|
Idiopathic chronic pancreatitis
|
|
0.010 |
GeneticVariation |
BEFREE |
The haplotype harboring the SPINK1 c.101A>G (p.Asn34Ser) variant (also known as rs17107315:T>C) represents the most important heritable risk factor for idiopathic chronic pancreatitis identified to date.
|
28556356 |
2017 |
|
rs10774579
|
HNF1A-AS1
|
C-reactive protein measurement
|
T |
0.700 |
GeneticVariation |
GWASDB |
Are C-reactive protein associated genetic variants associated with serum levels and retinal markers of microvascular pathology in Asian populations from Singapore?
|
23844046 |
2013 |
|
rs10774579
|
HNF1A-AS1
|
C-reactive protein measurement
|
|
0.700 |
GeneticVariation |
GWASDB |
Genome-wide association with C-reactive protein levels in CLHNS: evidence for the CRP and HNF1A loci and their interaction with exposure to a pathogenic environment.
|
21647738 |
2012 |
|
rs1169288
|
HNF1A;HNF1A-AS1
|
Low density lipoprotein cholesterol measurement
|
A |
0.800 |
GeneticVariation |
GWASCAT |
Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.
|
30275531 |
2018 |
|
rs1169288
|
HNF1A;HNF1A-AS1
|
Low density lipoprotein cholesterol measurement
|
A |
0.800 |
GeneticVariation |
GWASCAT |
Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels.
|
28334899 |
2017 |
|
rs1169288
|
HNF1A;HNF1A-AS1
|
Serum total cholesterol measurement
|
C |
0.800 |
GeneticVariation |
GWASDB |
Biological, clinical and population relevance of 95 loci for blood lipids.
|
20686565 |
2010 |
|
rs1169288
|
HNF1A;HNF1A-AS1
|
Serum gamma-glutamyl transferase measurement
|
G |
0.800 |
GeneticVariation |
GWASCAT |
Loci affecting gamma-glutamyl transferase in adults and adolescents show age × SNP interaction and cardiometabolic disease associations.
|
22010049 |
2012 |
|
rs1169288
|
HNF1A;HNF1A-AS1
|
Low density lipoprotein cholesterol measurement
|
C |
0.800 |
GeneticVariation |
GWASCAT |
Discovery and refinement of loci associated with lipid levels.
|
24097068 |
2013 |
|
rs1169288
|
HNF1A;HNF1A-AS1
|
Serum total cholesterol measurement
|
C |
0.800 |
GeneticVariation |
GWASDB |
Discovery and refinement of loci associated with lipid levels.
|
24097068 |
2013 |
|
rs1169288
|
HNF1A;HNF1A-AS1
|
Serum total cholesterol measurement
|
C |
0.800 |
GeneticVariation |
GWASCAT |
Biological, clinical and population relevance of 95 loci for blood lipids.
|
20686565 |
2010 |
|
rs1169288
|
HNF1A;HNF1A-AS1
|
Low density lipoprotein cholesterol measurement
|
C |
0.800 |
GeneticVariation |
GWASDB |
Discovery and refinement of loci associated with lipid levels.
|
24097068 |
2013 |
|
rs1169288
|
HNF1A;HNF1A-AS1
|
Serum total cholesterol measurement
|
C |
0.800 |
GeneticVariation |
GWASCAT |
Discovery and refinement of loci associated with lipid levels.
|
24097068 |
2013 |
|
rs1169288
|
HNF1A;HNF1A-AS1
|
Low density lipoprotein cholesterol measurement
|
C |
0.800 |
GeneticVariation |
GWASDB |
Biological, clinical and population relevance of 95 loci for blood lipids.
|
20686565 |
2010 |
|
rs1169288
|
HNF1A;HNF1A-AS1
|
Serum total cholesterol measurement
|
A |
0.800 |
GeneticVariation |
GWASCAT |
A large electronic-health-record-based genome-wide study of serum lipids.
|
29507422 |
2018 |
|
rs1169288
|
HNF1A;HNF1A-AS1
|
Low density lipoprotein cholesterol measurement
|
A |
0.800 |
GeneticVariation |
GWASCAT |
A large electronic-health-record-based genome-wide study of serum lipids.
|
29507422 |
2018 |
|
rs1169288
|
HNF1A;HNF1A-AS1
|
Serum gamma-glutamyl transferase measurement
|
G |
0.800 |
GeneticVariation |
GWASDB |
Loci affecting gamma-glutamyl transferase in adults and adolescents show age × SNP interaction and cardiometabolic disease associations.
|
22010049 |
2012 |
|
rs1169288
|
HNF1A;HNF1A-AS1
|
Low density lipoprotein cholesterol measurement
|
|
0.800 |
GeneticVariation |
GWASCAT |
Genetic analyses of diverse populations improves discovery for complex traits.
|
31217584 |
2019 |
|
rs1169288
|
HNF1A;HNF1A-AS1
|
Low density lipoprotein cholesterol measurement
|
C |
0.800 |
GeneticVariation |
GWASCAT |
Biological, clinical and population relevance of 95 loci for blood lipids.
|
20686565 |
2010 |
|
rs1169288
|
HNF1A;HNF1A-AS1
|
Serum total cholesterol measurement
|
A |
0.800 |
GeneticVariation |
GWASCAT |
Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.
|
30275531 |
2018 |
|
rs1169288
|
HNF1A;HNF1A-AS1
|
Low density lipoprotein cholesterol measurement
|
A |
0.800 |
GeneticVariation |
GWASCAT |
Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.
|
30926973 |
2019 |
|
rs1169288
|
HNF1A;HNF1A-AS1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.780 |
GeneticVariation |
BEFREE |
Amongst non-obese individuals, we observed significant T2D associations with HNF1A I27L [odds ratio (OR) = 1.14, P = 0.04], GCK -30G>A (OR = 1.23, P = 0.01), SLC30A8 R325W (OR = 0.87, P = 0.04), and TCF7L2 rs7903146 (OR = 1.89, P = 4.5 x 10-23), and non-significant associations with PPARG Pro12Ala (OR = 0.85, P = 0.14), ADIPOQ -11,377C>G (OR = 1.00, P = 0.97) and ENPP1 K121Q (OR = 0.99, P = 0.94).
|
18498634 |
2008 |
|
rs1169288
|
HNF1A;HNF1A-AS1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.780 |
GeneticVariation |
BEFREE |
In contrast, 33.3% of patients with type 2 diabetes mellitus and I27L polymorphism in the HNF1alpha gene had no family history of diabetes (p < 0.05).
|
20172480 |
2010 |
|
rs1169288
|
HNF1A;HNF1A-AS1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.780 |
GeneticVariation |
BEFREE |
The polymorphism rs1169288 in HNF-1alpha strongly predicted future type 2 diabetes (hazard ratio [HR] 1.2, P = 0.0002).
|
18332101 |
2008 |
|
rs1169288
|
HNF1A;HNF1A-AS1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.780 |
GeneticVariation |
BEFREE |
In this study, we asked whether the co-occurrence of risk alleles in or near five genes modulating insulin secretion (TCF7L2 rs7903146, IGF2BP2 rs4402960, CDKAL1 rs7754840, HHEX rs1111875, and HNF1A rs1169288) is associated with a higher risk of IGT/T2D in obese children and adolescents.
|
24062323 |
2014 |
|
rs1169288
|
HNF1A;HNF1A-AS1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.780 |
GeneticVariation |
BEFREE |
The Common <i>HNF1A</i> Variant I27L Is a Modifier of Age at Diabetes Diagnosis in Individuals With HNF1A-MODY.
|
29895593 |
2018 |