|
rs7453920
|
HLA-DQB2
|
Ankylosing spondylitis
|
|
0.010 |
GeneticVariation |
BEFREE |
This is the first study demonstrating the significant associations of SNP rs7453920 and the haplotypes in the HLA gene with the risk of AS in Southwest Chinese population.
|
27394003 |
2016 |
|
rs7453920
|
HLA-DQB2
|
Complete atrioventricular block
|
|
0.010 |
GeneticVariation |
BEFREE |
Association of CHB with SNPs rs2856718 and rs7453920 remains significant even after stratification with rs3077 and rs9277535, indicating independent effect of HLA-DQ variants on CHB susceptibility (P-value of 1.52 × 10(-21)- 2.38 × 10(-30)).
|
21750111 |
2011 |
|
rs754855896
|
HLA-DQB2
|
Diabetes
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of our study was to evaluate the frequency of the L-selectin gene T668C mutation (from thymine to cytosine at position 668) resulted in F206L an amino acid substitution in patients with overt diabetes and their unaffected first degree relatives in comparison to the unselected control population.
|
11064106 |
2000 |
|
rs754855896
|
HLA-DQB2
|
Diabetes Mellitus
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of our study was to evaluate the frequency of the L-selectin gene T668C mutation (from thymine to cytosine at position 668) resulted in F206L an amino acid substitution in patients with overt diabetes and their unaffected first degree relatives in comparison to the unselected control population.
|
11064106 |
2000 |
|
rs1573649
|
HLA-DQB2
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.700 |
GeneticVariation |
GWASDB |
A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene.
|
17632545 |
2007 |
|
rs2051549
|
HLA-DQB2
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.700 |
GeneticVariation |
GWASDB |
A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene.
|
17632545 |
2007 |
|
rs2071550
|
HLA-DQB2
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.700 |
GeneticVariation |
GWASDB |
A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene.
|
17632545 |
2007 |
|
rs2301271
|
HLA-DQB2
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.700 |
GeneticVariation |
GWASDB |
A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene.
|
17632545 |
2007 |
|
rs6903130
|
HLA-DQB2
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.700 |
GeneticVariation |
GWASDB |
A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene.
|
17632545 |
2007 |
|
rs7453920
|
HLA-DQB2
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.700 |
GeneticVariation |
GWASDB |
A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene.
|
17632545 |
2007 |
|
rs7756516
|
HLA-DQB2
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.700 |
GeneticVariation |
GWASDB |
A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene.
|
17632545 |
2007 |
|
rs754855896
|
HLA-DQB2
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.010 |
GeneticVariation |
BEFREE |
It was also shown that there is an association between T668C mutation and low HLA related risk of IDDM development, the highest frequency of F206L mutation in the EGF domain of L-selectin was observed in relatives with 'protective' HLA DQB1*0602 allele and nonDRB1*03-nonDRB1*04 haplotype, while in subjects with highest risk of IDDM haplotype the frequency of T668C mutation was similar to the controls.
|
11064106 |
2000 |
|
rs2071550
|
HLA-DQB2
|
Diastolic blood pressure
|
|
0.700 |
GeneticVariation |
GWASCAT |
A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure.
|
29455858 |
2018 |
|
rs7453920
|
HLA-DQB2
|
Hepatitis B
|
G |
0.880 |
GeneticVariation |
GWASDB |
We found that rs9277535 (HLA-DPB1, P = 4.87×10(-14)), rs9276370 (HLA-DQA2, P = 1.9×10(-12)), rs7756516 and rs7453920 (HLA-DQB2, P = 1.48×10(-11) and P = 6.66×10(-15) respectively) were significantly associated with persistent HBV infection.
|
24940741 |
2014 |
|
rs7453920
|
HLA-DQB2
|
Hepatitis B
|
|
0.880 |
GeneticVariation |
BEFREE |
In addition, Uygurs have higher frequencies of HLA-DP/DQ protective alleles (72.5% for rs3077, 76.6% for rs9277535 and 26.8% for rs7453920) than Tibetans (51.7% for rs3077, 52.5% for rs9277535 and 18.5% for rs7453920)(all P < 0.05), and a lower prevalence of HBV infection as previously reported.
|
25041342 |
2015 |
|
rs7453920
|
HLA-DQB2
|
Hepatitis B
|
G |
0.880 |
GeneticVariation |
GWASDB |
New loci associated with chronic hepatitis B virus infection in Han Chinese.
|
24162738 |
2013 |
|
rs7453920
|
HLA-DQB2
|
Hepatitis B
|
|
0.880 |
GeneticVariation |
BEFREE |
No significant correlation was shown in HLA-DP rs3077 and rs9277535 with HBV infection or liver function recovery (P < .05).Our study concluded that HLA-DP (rs3077 and rs9277535) and HLA-DQ (rs7453920) were not significantly associated with HBV recurrence or HBV susceptibility, but HLA-DQ rs7453920 was related to prognosis of liver transplant recipients.
|
28640108 |
2017 |
|
rs7453920
|
HLA-DQB2
|
Hepatitis B
|
|
0.880 |
GeneticVariation |
BEFREE |
The pooled risk estimates indicated that HLA-DQ rs7453920-A polymorphism was associated with decreased risk of HBV infection, and rs7453920-G serves as a risk factor in HBV infection.
|
28512640 |
2017 |
|
rs7453920
|
HLA-DQB2
|
Hepatitis B
|
G |
0.880 |
GeneticVariation |
GWASCAT |
New loci associated with chronic hepatitis B virus infection in Han Chinese.
|
24162738 |
2013 |
|
rs7453920
|
HLA-DQB2
|
Hepatitis B
|
|
0.880 |
GeneticVariation |
BEFREE |
These results indicate that rs9277535 and rs3077 in HLA-DP are the major determinants of response to hepatitis B vaccine, whereas rs2856718 and rs7453920 in HLA-DQ have little effect on the immune response to hepatitis B vaccine.
|
28882445 |
2017 |
|
rs7453920
|
HLA-DQB2
|
Hepatitis B
|
|
0.880 |
GeneticVariation |
BEFREE |
Recent genome-wide association studies showed that four single-nucleotide polymorphisms (SNPs) in human leukocyte antigen (HLA)-DP (rs3077 and rs9277535) and HLA-DQ (rs2856718 and rs7453920) were associated with chronic hepatitis B virus (HBV) infection in Japanese populations.
|
22105689 |
2012 |
|
rs7453920
|
HLA-DQB2
|
Hepatitis B
|
|
0.880 |
GeneticVariation |
BEFREE |
SNPs of HLA-DPA1 (rs3077), HLA-DPB1 (rs9277542), HLA-DQB1 (rs2856718) and HLA-DQB2 (rs7453920) were determined, and HBV genotyping was performed by phylogenetic analysis in HBV patients.
|
28267888 |
2017 |
|
rs7453920
|
HLA-DQB2
|
Hepatitis B
|
|
0.880 |
GeneticVariation |
BEFREE |
The SNPs of HLA-DQ (rs2856718 and rs7453920) were determined in 299 patients with chronic HBV infection.
|
27580643 |
2017 |
|
rs7453920
|
HLA-DQB2
|
Hepatitis B
|
G |
0.880 |
GeneticVariation |
GWASCAT |
A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population.
|
21750111 |
2011 |
|
rs7453920
|
HLA-DQB2
|
Hepatitis B
|
|
0.880 |
GeneticVariation |
BEFREE |
We found that rs9277535 (HLA-DPB1, P = 4.87×10(-14)), rs9276370 (HLA-DQA2, P = 1.9×10(-12)), rs7756516 and rs7453920 (HLA-DQB2, P = 1.48×10(-11) and P = 6.66×10(-15) respectively) were significantly associated with persistent HBV infection.
|
24940741 |
2014 |