IL10, interleukin 10, 3586

N. diseases: 1679; N. variants: 21
Disease: Crohn Disease ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs3024493
rs3024493
Entrez Id: 3586;29949
Gene Symbol: IL10;IL19
IL10;IL19
CUI: C0010346
Disease:
Crohn Disease 		0.700 GeneticVariation GWASCAT Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. 26974007 2016
dbSNP: rs145922845
rs145922845
Entrez Id: 3586;29949
Gene Symbol: IL10;IL19
IL10;IL19
CUI: C0010346
Disease:
Crohn Disease 		0.030 GeneticVariation BEFREE The interleukin-10 Gly15Arg mutation is rare in patients with Crohn's disease, and is not associated with the disease in the Netherlands. 15843082 2005
dbSNP: rs145922845
rs145922845
Entrez Id: 3586;29949
Gene Symbol: IL10;IL19
IL10;IL19
CUI: C0010346
Disease:
Crohn Disease 		0.030 GeneticVariation BEFREE A Gly15Arg mutation in the leader sequence of IL-10 was found in a multiple CD-affected family. 12825869 2003
dbSNP: rs145922845
rs145922845
Entrez Id: 3586;29949
Gene Symbol: IL10;IL19
IL10;IL19
CUI: C0010346
Disease:
Crohn Disease 		0.030 GeneticVariation BEFREE Screening of the coding region of the IL-10 gene by polymerase chain reaction--single strand conformation polymorphism (PCR-SSCP) analysis revealed a rare sequence variation in exon 1 leading to an amino acid exchange (G-->A; G15R) in two patients with CD and five healthy controls. 11271474 2000
dbSNP: rs1800871
rs1800871
Entrez Id: 3586;29949
Gene Symbol: IL10;IL19
IL10;IL19
CUI: C0010346
Disease:
Crohn Disease 		0.020 GeneticVariation BEFREE Single nucleotide polymorphisms (SNPs) that affect IL-10 production, such as rs1800896 (G/A) at position -1082 and rs1800871 (C/T) at position -819 in the promoter region of the IL10 gene, have been associated with CD and/or UC, but the results were inconsistent. 27558476 2016
dbSNP: rs1800896
rs1800896
Entrez Id: 3586;29949
Gene Symbol: IL10;IL19
IL10;IL19
CUI: C0010346
Disease:
Crohn Disease 		0.020 GeneticVariation BEFREE Single nucleotide polymorphisms (SNPs) that affect IL-10 production, such as rs1800896 (G/A) at position -1082 and rs1800871 (C/T) at position -819 in the promoter region of the IL10 gene, have been associated with CD and/or UC, but the results were inconsistent. 27558476 2016
dbSNP: rs1800896
rs1800896
Entrez Id: 3586;29949
Gene Symbol: IL10;IL19
IL10;IL19
CUI: C0010346
Disease:
Crohn Disease 		0.020 GeneticVariation BEFREE We demonstrated an association with CD for SNPs rs3024505 and rs1800896, and phenotypic analysis indicated an association of rs3024505 with an early age at first diagnosis, stricturing CD behavior, and requirement for bowel resection. 21354456 2011
dbSNP: rs1800871
rs1800871
Entrez Id: 3586;29949
Gene Symbol: IL10;IL19
IL10;IL19
CUI: C0010346
Disease:
Crohn Disease 		0.020 GeneticVariation BEFREE Of the five IL-10 tag-SNPs, rs2222202 (C/T) (P = 0.03) and rs1800871 (C/T) (P = 0.05) showed significant allelic associations with CD. 19210299 2009
dbSNP: rs2222202
rs2222202
Entrez Id: 3586;29949
Gene Symbol: IL10;IL19
IL10;IL19
CUI: C0010346
Disease:
Crohn Disease 		0.010 GeneticVariation BEFREE Of the five IL-10 tag-SNPs, rs2222202 (C/T) (P = 0.03) and rs1800871 (C/T) (P = 0.05) showed significant allelic associations with CD. 19210299 2009