Disease: Neoplastic Syndromes, Hereditary ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs745677716
rs745677716
Entrez Id: 4361
Gene Symbol: MRE11
MRE11
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		G 0.700 GeneticVariation CLINVAR Male breast cancer in a multi-gene panel testing cohort: insights and unexpected results. 28008555 2017
dbSNP: rs371077728
rs371077728
Entrez Id: 4361;100302275
Gene Symbol: MRE11;MIR548L
MRE11;MIR548L
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		A 0.700 CausalMutation CLINVAR Evaluation of ACMG-Guideline-Based Variant Classification of Cancer Susceptibility and Non-Cancer-Associated Genes in Families Affected by Breast Cancer. 27153395 2016
dbSNP: rs587780138
rs587780138
Entrez Id: 4361
Gene Symbol: MRE11
MRE11
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		A 0.700 GeneticVariation CLINVAR Rare disruptive mutations and their contribution to the heritable risk of colorectal cancer. 27329137 2016
dbSNP: rs587781384
rs587781384
Entrez Id: 4361
Gene Symbol: MRE11
MRE11
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		A 0.700 CausalMutation CLINVAR Panel Testing for Familial Breast Cancer: Calibrating the Tension Between Research and Clinical Care. 26786923 2016
dbSNP: rs587781822
rs587781822
Entrez Id: 4361
Gene Symbol: MRE11
MRE11
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		C 0.700 GeneticVariation CLINVAR Germline Variants in Targeted Tumor Sequencing Using Matched Normal DNA. 26556299 2016
dbSNP: rs786202801
rs786202801
Entrez Id: 4361
Gene Symbol: MRE11
MRE11
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		T 0.700 GeneticVariation CLINVAR Prioritizing Variants in Complete Hereditary Breast and Ovarian Cancer Genes in Patients Lacking Known BRCA Mutations. 26898890 2016
dbSNP: rs371077728
rs371077728
Entrez Id: 4361;100302275
Gene Symbol: MRE11;MIR548L
MRE11;MIR548L
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		A 0.700 CausalMutation CLINVAR Prevalence of mutations in a panel of breast cancer susceptibility genes in BRCA1/2-negative patients with early-onset breast cancer. 25503501 2015
dbSNP: rs587781822
rs587781822
Entrez Id: 4361
Gene Symbol: MRE11
MRE11
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		C 0.700 GeneticVariation CLINVAR Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT): A Hybridization Capture-Based Next-Generation Sequencing Clinical Assay for Solid Tumor Molecular Oncology. 25801821 2015
dbSNP: rs951805101
rs951805101
Entrez Id: 4361
Gene Symbol: MRE11
MRE11
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		C 0.700 CausalMutation CLINVAR Germline Mutations in Predisposition Genes in Pediatric Cancer. 26580448 2015
dbSNP: rs371077728
rs371077728
Entrez Id: 4361;100302275
Gene Symbol: MRE11;MIR548L
MRE11;MIR548L
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		A 0.700 CausalMutation CLINVAR Utilization of multigene panels in hereditary cancer predisposition testing: analysis of more than 2,000 patients. 24763289 2014
dbSNP: rs137852759
rs137852759
Entrez Id: 4361
Gene Symbol: MRE11
MRE11
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		A 0.700 CausalMutation CLINVAR Disease-associated MRE11 mutants impact ATM/ATR DNA damage signaling by distinct mechanisms. 23912341 2013
dbSNP: rs137852761
rs137852761
Entrez Id: 4361
Gene Symbol: MRE11
MRE11
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		A 0.700 CausalMutation CLINVAR Clinical course of two Italian siblings with ataxia-telangiectasia-like disorder. 23436002 2013
dbSNP: rs137852759
rs137852759
Entrez Id: 4361
Gene Symbol: MRE11
MRE11
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		A 0.700 CausalMutation CLINVAR Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling. 22863007 2012
dbSNP: rs587780138
rs587780138
Entrez Id: 4361
Gene Symbol: MRE11
MRE11
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		A 0.700 GeneticVariation CLINVAR Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing. 22006311 2011
dbSNP: rs759130031
rs759130031
Entrez Id: 4361
Gene Symbol: MRE11
MRE11
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		T 0.700 CausalMutation CLINVAR Two unrelated patients with MRE11A mutations and Nijmegen breakage syndrome-like severe microcephaly. 21227757 2011
dbSNP: rs137852759
rs137852759
Entrez Id: 4361
Gene Symbol: MRE11
MRE11
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		A 0.700 CausalMutation CLINVAR Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene. 19383352 2008
dbSNP: rs137852761
rs137852761
Entrez Id: 4361
Gene Symbol: MRE11
MRE11
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		A 0.700 CausalMutation CLINVAR Involvement of novel autophosphorylation sites in ATM activation. 16858402 2006
dbSNP: rs137852759
rs137852759
Entrez Id: 4361
Gene Symbol: MRE11
MRE11
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		A 0.700 CausalMutation CLINVAR Molecular basis of ataxia telangiectasia and related diseases. 16038621 2005
dbSNP: rs137852761
rs137852761
Entrez Id: 4361
Gene Symbol: MRE11
MRE11
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		A 0.700 CausalMutation CLINVAR MRE11 mutations and impaired ATM-dependent responses in an Italian family with ataxia-telangiectasia-like disorder. 15269180 2004
dbSNP: rs137852761
rs137852761
Entrez Id: 4361
Gene Symbol: MRE11
MRE11
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		A 0.700 CausalMutation CLINVAR hMRE11: genomic structure and a null mutation identified in a transcript protected from nonsense-mediated mRNA decay. 11371508 2001
dbSNP: rs137852759
rs137852759
Entrez Id: 4361
Gene Symbol: MRE11
MRE11
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		A 0.700 CausalMutation CLINVAR The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder. 10612394 1999
dbSNP: rs1215450873
rs1215450873
Entrez Id: 4361
Gene Symbol: MRE11
MRE11
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		A 0.700 CausalMutation CLINVAR
dbSNP: rs1264516058
rs1264516058
Entrez Id: 4361
Gene Symbol: MRE11
MRE11
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		A 0.700 CausalMutation CLINVAR
dbSNP: rs1295485913
rs1295485913
Entrez Id: 4361
Gene Symbol: MRE11
MRE11
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		A 0.700 GeneticVariation CLINVAR
dbSNP: rs1376550081
rs1376550081
Entrez Id: 4361
Gene Symbol: MRE11
MRE11
CUI: C0027672
Disease:
Neoplastic Syndromes, Hereditary 		A 0.700 CausalMutation CLINVAR