TLR8, toll like receptor 8, 51311

N. diseases: 122; N. variants: 8
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2407992
rs2407992
Entrez Id: 51311;349408
Gene Symbol: TLR8;TLR8-AS1
TLR8;TLR8-AS1
CUI: C0011854
Disease:
Diabetes Mellitus, Insulin-Dependent 		0.010 GeneticVariation BEFREE The most significant association was with two T1D SNPs, rs12150079 (ZPBP2/ORMDL3/GSDMB region) (enterovirus frequency: AA 7.3%, AG 8.7%, GG 9.7%, RR = 0.86, overall p = 1.87E-02) and rs229541 (C1QTNF6/SSTR3/RAC2) (enterovirus frequency: CC 7.8%, CT 9.7%, TT 9.4%, RR = 1.13, overall p = 3.6E-02), followed by TLR8 (rs2407992) (p = 3.8E-02), TLR3 (1914926) (p = 4.9E-02), and two other T1D SNPs (IFIH1 rs3747517, p = 4.9E-02 and PTPN22, rs2476601, p = 5.3E-02). 26485223 2015
dbSNP: rs3764879
rs3764879
Entrez Id: 51311;349408
Gene Symbol: TLR8;TLR8-AS1
TLR8;TLR8-AS1
CUI: C0041327
Disease:
Tuberculosis, Pulmonary 		0.010 GeneticVariation BEFREE The frequencies of the GG genotype of SNP rs7873784 in TLR4 (OR = 2.136; 95% CI: 1.312-3.478) and the CC genotype of rs3764879 in TLR8 (OR = 1.982; 95% CI: 1.292-3.042) were also significantly higher in the PTB group than in the HC group. 25928077 2015
dbSNP: rs3764880
rs3764880
Entrez Id: 51311;349408
Gene Symbol: TLR8;TLR8-AS1
TLR8;TLR8-AS1
CUI: C0022658
Disease:
Kidney Diseases 		0.010 GeneticVariation BEFREE Carrier frequencies of the minor alleles of TLR1 p.His305Leu (OR = 4.79, 95% CI = 2.35-9.75, P = 0.0002), TLR1 p.Asn248Ser (OR = 1.26, 95% CI = 1.07-1.47, P = 0.04) and TLR8 p.Met1Val (OR = 1.37, 95% CI = 1.14-1.64, P = 0.008) were significantly higher in patients with ESRD, with little specificity for the underlying renal disease entity (adjusted for age, gender and donor-recipient relatedness). 26445497 2015
dbSNP: rs5744069
rs5744069
Entrez Id: 51311;349408
Gene Symbol: TLR8;TLR8-AS1
TLR8;TLR8-AS1
CUI: C0019196
Disease:
Hepatitis C 		0.010 GeneticVariation BEFREE When data were stratified by major HCV genotypes, patients infected with HCV genotype 1 (GT1) had significant values for both rs1013151 and rs5744069 polymorphisms [aOR=5.79 (95%CI=1.44; 23.32) (p=0.013) and aOR=8.01 (95%CI=2.16; 35.65) (p=0.005); respectively]. 26455634 2015
dbSNP: rs3764880
rs3764880
Entrez Id: 51311;349408
Gene Symbol: TLR8;TLR8-AS1
TLR8;TLR8-AS1
CUI: C0031039
Disease:
Pericardial effusion 		0.010 GeneticVariation BEFREE TLR7 rs3853839-G (G vs. C: p = 0.0100) and TLR8 rs3764880-G (recessive model: p = 0.0173; additive model: p = 0.0161) were associated with pericardial effusion in females relative to healthy females. 24445780 2014
dbSNP: rs3764880
rs3764880
Entrez Id: 51311;349408
Gene Symbol: TLR8;TLR8-AS1
TLR8;TLR8-AS1
CUI: C0019099
Disease:
Hemorrhagic Fever, Crimean 		0.010 GeneticVariation BEFREE We found that heterozygous plus homozygous mutant genotypes frequency for TLR8 Met1Val and for TLR9 -1486T/C were significantly higher in CCHF patients than controls (p = 0.038 and p = 0.009, respectively). 20674764 2010
dbSNP: rs3764879
rs3764879
Entrez Id: 51311;349408
Gene Symbol: TLR8;TLR8-AS1
TLR8;TLR8-AS1
CUI: C1956346
Disease:
Coronary Artery Disease 		0.010 GeneticVariation BEFREE These results do not support an involvement of SNPs rs3764879 and rs3764880 of TLR8 in predisposition to CAD. 18985439 2009
dbSNP: rs3764880
rs3764880
Entrez Id: 51311;349408
Gene Symbol: TLR8;TLR8-AS1
TLR8;TLR8-AS1
CUI: C1956346
Disease:
Coronary Artery Disease 		0.010 GeneticVariation BEFREE These results do not support an involvement of SNPs rs3764879 and rs3764880 of TLR8 in predisposition to CAD. 18985439 2009
dbSNP: rs2407992
rs2407992
Entrez Id: 51311;349408
Gene Symbol: TLR8;TLR8-AS1
TLR8;TLR8-AS1
CUI: C0004096
Disease:
Asthma 		0.010 GeneticVariation BEFREE The most significant association was seen for rs2407992 (TLR8) in asthma (p = 0.00023, sample A and B combined, recessive model). 18682521 2008