|
Major Depressive Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
We found that rs1006737 was associated with both schizophrenia (P(allele) = 0.0014, P(genotype) = 0.006, odds ratio (OR) = 1.384, 95% CI 1.134-1.690) and major depressive disorder (P(allele) = 0.0007, P(genotype) = 0.003, OR = 1.425, 95% CI 1.160-1.752).
|
24262814 |
2014 |
|
Bipolar Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
This is most interesting because the common single-nucleotide polymorphism (SNP) most highly associated with BD is rs1006737, which we show here is a cis-expression quantitative trait locus for CACNA1C in human cerebellum, and the risk allele (A) is associated with decreased expression.
|
23979604 |
2014 |
|
Bipolar Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recent genetic studies found the A allele of the variant rs1006737 in the alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene to be overrepresented in patients suffering from bipolar disorder, schizophrenia or major depression.
|
19781653 |
2010 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
CACNA1C risk variant rs1006737 affects cortical white matter integrity in schizophrenia.
|
25470093 |
2014 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
These results add to the literature suggesting that rs1006737 may be associated with schizophrenia through its detrimental effect on endophenotypic traits.
|
22957138 |
2012 |
|
Bipolar Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
On the other hand, our results indicate that alterations in the functional coupling between the prefrontal cortex and the medial temporal lobe could represent a neural system phenotype that is mediated by CACNA1C rs1006737 and other genetic susceptibility loci for schizophrenia and bipolar disorder.
|
23404764 |
2014 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our results further confirmed that rs1006737 should be categorized as an authentic risk SNP for schizophrenia in the general populations.
|
25588813 |
2015 |
|
Bipolar Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our data demonstrate that the effect of CACNA1C rs1006737 and ANK3 rs10994336 (or genetic variants in linkage disequilibrium) on the brain converges on the neural circuitry involved in affect processing and provides a mechanism linking BD to genome-wide genetic risk variants.
|
24108394 |
2013 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
CACNA1C-rs1006737 and ZNF804A-rs1344706 polymorphisms are among the most robustly associated with schizophrenia (SCZ) and bipolar disorder (BD), and recently with brain phenotypes.
|
30079586 |
2019 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
We found that rs1006737 was associated with both schizophrenia (P(allele) = 0.0014, P(genotype) = 0.006, odds ratio (OR) = 1.384, 95% CI 1.134-1.690) and major depressive disorder (P(allele) = 0.0007, P(genotype) = 0.003, OR = 1.425, 95% CI 1.160-1.752).
|
24262814 |
2014 |
|
Bipolar Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
The polymorphism rs1006737 within the CACNA1C gene is associated with increased risk for bipolar disorder (BD) and variations in brain morphology and function of subcortical regions.
|
21292451 |
2011 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Genome-wide association studies have reported an association between the A-allele of rs1006737 within CACNA1C and affective disorders and schizophrenia.
|
22665259 |
2013 |
|
Bipolar Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our data demonstrate that rs1006737 or genetic variants in linkage disequilibrium with it are functional in the human brain and provide a neurogenetic risk mechanism for bipolar disorder backed by genome-wide evidence.
|
20679588 |
2010 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Nine teams, including four European decent samples and five Asian samples, contributed 14,141 cases and 30,679 controls for the analysis of CACNA1C rs1006737 and SZ.
|
26227746 |
2015 |
|
Major Depressive Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recent genetic studies found the A allele of the variant rs1006737 in the alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene to be overrepresented in patients suffering from bipolar disorder, schizophrenia or major depression.
|
19781653 |
2010 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recent genetic studies found the A allele of the variant rs1006737 in the alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene to be over-represented in patients with psychosis, including schizophrenia, bipolar disorder and major depressive disorder.
|
21078228 |
2011 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Specifically, genome wide association studies (GWAS) have repeatedly identified the single nucleotide polymorphism (SNP) rs1006737 in intron 3 of CACNA1C to be strongly associated with schizophrenia and bipolar disorder.
|
27276213 |
2016 |
|
Bipolar Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
Strong evidence (P=7.0 × 10(-7)) of association at the polymorphism rs1006737 (within CACNA1C, the gene encoding the α-1C subunit of the L-type voltage-gated calcium channel) with the risk of bipolar disorder (BD) has recently been reported in a meta-analysis of three genome-wide association studies of BD, including our BD sample (N=1868) studied within the Wellcome Trust Case Control Consortium.
|
19621016 |
2010 |
|
Bipolar Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
Genotyping results indicated that rs1006737 in CACNA1C was significantly associated with BD, while rs10994336 or rs9804190 in ANK3 was not significant when examined individually.
|
29684488 |
2018 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our results provide further support for associations of rs1006737</span> and rs1024582 with schizophrenia, identify a new risk locus rs2007044 in a Han Chinese population, and further establish CACNA1C as an important susceptibility gene for the disease across world populations.
|
24355530 |
2014 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Several genetic studies have implicated the CACNA1C SNP rs1006737 in bipolar disorder (BD) and schizophrenia (SZ) pathology.
|
23437284 |
2013 |
|
Bipolar Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recent genetic studies found the A allele of the variant rs1006737 in the alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene to be over-represented in patients with psychosis, including schizophrenia, bipolar disorder and major depressive disorder.
|
21078228 |
2011 |
|
Major Depressive Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
The single nucleotide polymorphisms FKBP5:rs1360780, BDNF:rs6265 (Val66Met), P2RX7:2230912 (Gln460Arg) and CACNA1C:rs1006737 were genotyped in DNA from 457 depression cases (major depression, dysthymia, and mixed anxiety depression) and 2286 healthy controls with no symptom of psychopathology.
|
20226536 |
2010 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Further analysis of the haplotype rs1006737-rs4765905-rs882194 in CACNA1C showed significant associations with schizophrenia (corrected global p<0.005), and two haplotypes (ACC and ACT) in the block were significantly increased in the patients.
|
24275578 |
2014 |
|
Major Depressive Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
The current data provide further evidence for an impact of rs1006737 on the left IFG and demonstrate that genetic variation in CACNA1C modulates neural responses in patients with MDD.
|
24612926 |
2014 |