|
Major Depressive Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
The study population comprised 188 healthy first-degree relatives of patients with bipolar disorder (n=59), major depression (n=73), and schizophrenia (n=56) and 110 comparison subjects from our discovery study who were genotyped for rs1006737 and underwent functional magnetic resonance imaging while performing an episodic memory task and psychological testing.
|
24411473 |
2014 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
The rs10994336 ANK3 and rs1006737 CACNA1C genetic variants have recently been identified as the most consistent, genome-wide significant risk factors for bipolar disorder, while the CACNA1C variant has also been associated with schizophrenia and major depression.
|
21676128 |
2011 |
|
Major Depressive Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recent genetic studies found the A allele of the variant rs1006737 in the alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene to be over-represented in patients with psychosis, including schizophrenia, bipolar disorder and major depressive disorder.
|
21078228 |
2011 |
|
Bipolar Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
Specifically, genome wide association studies (GWAS) have repeatedly identified the single nucleotide polymorphism (SNP) rs1006737 in intron 3 of CACNA1C to be strongly associated with schizophrenia and bipolar disorder.
|
27276213 |
2016 |
|
Bipolar Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
Genome-wide studies have identified allele A (adenine) of single nucleotide polymorphism (SNP) rs1006737 of the calcium-channel CACNA1C gene as a risk factor for both schizophrenia (SZ) and bipolar disorder (BD) as well as allele A for rs1344706 in the ZNF804A gene.
|
27790829 |
2017 |
|
Bipolar Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
Although we were not able to replicate findings of association between individual CACNA1C SNPs rs7297582 and rs1006737 and BP, we were able to replicate the GWAS signal reported for CACNA1C through a haplotype analysis that encompassed these previously reported significant SNPs.
|
23437964 |
2013 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Both CACNA1C (rs1006737) and KCNH2 (rs3800779) were genotyped in 101 controls and 50 schizophrenia patients.
|
30607529 |
2019 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recent genetic studies found the A allele of the variant rs1006737 in the alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene to be overrepresented in patients suffering from bipolar disorder, schizophrenia or major depression.
|
19781653 |
2010 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our data suggests a minor involvement of CACNA1C rs1006737 in psychosis via conferring susceptibility to white matter microstructural abnormalities in SZ.
|
27790829 |
2017 |
|
Bipolar Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our study further supports the association of SNP rs1006737 with BD-I and suggests that CACNA1C SNP rs1006737 and Bcl-2 SNP rs956572, or specific causal variants in LD with these proxies, act independently to increase risk and ICDH in BD-I.
|
25843436 |
2016 |
|
Bipolar Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
A total of 109 BD type I subjects and 96 controls were genotyped for CACNA1C rs1006737 and assessed with an executive function tests battery [Wechsler Adult Intelligence Scale III (WAIS-III) Letter-Number Sequence subtest (WAIS-LNS), digit span (WAISDS), trail making test (TMT), and WCST (Wisconsin Card Sorting Test)].
|
23406546 |
2013 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
We performed a comprehensive meta-analysis of all available samples from existing studies under four different genetic models (recessive model, dominant model, additive model and allele model) to further confirm whether CACNA1C rs1006737 is an authentic risk single nucleotide polymorphism (SNP) for schizophrenia.
|
31033230 |
2019 |
|
Bipolar Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
The single nucleotide polymorphism at rs1006737 in CACNA1C has been associated with both schizophrenia and bipolar disorder and with several intermediate phenotypes that may serve as neurobiological antecedents, linking psychosis to genetic aetiology.
|
26048451 |
2016 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
CACNA1C gene polymorphism (rs1006737) is a susceptibility factor for both schizophrenia (SCZ) and bipolar disorder (BP).
|
22012475 |
2012 |
|
Major Depressive Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
Though rs1006737 in the CACNA1C gene showed significant association with MDD in a British large-scale candidate association study, most of the replication analyses with relatively small sample size reported negative association.
|
27260792 |
2016 |
|
Major Depressive Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recent genome-wide association studies have pointed to single-nucleotide polymorphisms (SNPs) in genes encoding the neuronal calcium channel CaV1.2 (CACNA1C; rs1006737) and the presynaptic active zone protein Piccolo (PCLO; rs2522833) as risk factors for affective disorders, particularly major depression.
|
24643163 |
2014 |
|
Bipolar Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
We found a significant association between the risk allele in rs1006737 and a decreased CSF hyperphosphorylated tau/total tau ratio in patients with bipolar disorder, thus linking variation in the CACNA1C gene to a neurochemical marker of neuroaxonal plasticity in those with this disorder.
|
26541689 |
2016 |
|
Bipolar Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
Several genetic studies have implicated the CACNA1C SNP rs1006737 in bipolar disorder</span> (BD) and schizophrenia (SZ) pathology.
|
23437284 |
2013 |
|
Bipolar Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
The rs10994336 ANK3 and rs1006737 CACNA1C genetic variants have recently been identified as the most consistent, genome-wide significant risk factors for bipolar disorder, while the CACNA1C variant has also been associated with schizophrenia and major depression.
|
21676128 |
2011 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Here, we have used our UK case samples of recurrent major depression (N=1196) and schizophrenia (N=479) and UK non-psychiatric comparison groups (N=15316) to examine the spectrum of phenotypic effect of the bipolar risk allele at rs1006737.
|
19621016 |
2010 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our findings further support a role for the CACNA1C gene, particularly for the rs1006737, in SCZ.
|
26049408 |
2015 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
The variant at rs1006737 in the L-type voltage-gated calcium channel (alpha 1c subunit) CACNA1C gene is reliably associated with both bipolar disorder and schizophrenia.
|
25290268 |
2014 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
The single nucleotide polymorphism at rs1006737 in CACNA1C has been associated with both schizophrenia and bipolar disorder and with several intermediate phenotypes that may serve as neurobiological antecedents, linking psychosis to genetic aetiology.
|
26048451 |
2016 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
On the other hand, our results indicate that alterations in the functional coupling between the prefrontal cortex and the medial temporal lobe could represent a neural system phenotype that is mediated by CACNA1C rs1006737 and other genetic susceptibility loci for schizophrenia and bipolar disorder.
|
23404764 |
2014 |
|
Major Depressive Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
Suggestive but notable results were (a) gene-based tests suggesting roles for adenylate cyclase 3 (ADCY3, 2p23.3) and galanin (GAL, 11q13.3); published functional evidence relates both of these to MDD and serotonergic signaling; (b) support for the bipolar disorder risk variant SNP rs1006737 in CACNA1C (P=0.020, odds ratio=1.10); and (c) lack of support for rs2251219, a SNP identified in a meta-analysis of affective disorder studies (P=0.51).
|
21042317 |
2012 |