|
Serum LDL cholesterol measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |
|
Serum total cholesterol measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |
|
Serum albumin measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
|
22286219 |
2012 |
|
Squamous cell carcinoma
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genetic variants at 6p21.1 and 7p15.3 are associated with risk of multiple cancers in Han Chinese.
|
23103227 |
2012 |
|
Serum LDL cholesterol measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genetic variants influencing circulating lipid levels and risk of coronary artery disease.
|
20864672 |
2010 |
|
Serum LDL cholesterol measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Common variants at 30 loci contribute to polygenic dyslipidemia.
|
19060906 |
2009 |
|
Serum LDL cholesterol measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Newly identified loci that influence lipid concentrations and risk of coronary artery disease.
|
18193043 |
2008 |
|
Aortic Aneurysm, Abdominal
|
|
0.010 |
GeneticVariation
|
BEFREE |
Finally, the LDL-C-lowering allele of rs11206510 in PCSK9 was weakly associated with a lower AAA risk (OR, 0.94; 95% CI, 0.88-1.00; P = .04), but a second independent LDL-C-lowering variant in PCSK9 (rs2479409) was not associated with AAA risk (OR, 0.97; 95% CI, 0.92-1.02; P = .28).
|
29188294 |
2018 |
|
Polycystic Ovary Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
The objective of this study was to evaluate the PCSK9 polymorphisms rs505151 (c.2009A>G), rs562556 (c.1420A>G) and rs11206510 (T>C) and plasma PCSK9 levels in PCOS.
|
29109005 |
2018 |
|
Cardiovascular Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
Therefore, we hypothesized that certain <i>PCSK9</i> genetic variants may modify the association between LC n-3 PUFA intake and CVD risk.<b>Objective:</b> We determined whether a <i>PCSK9</i> variant (rs11206510), which has been identified for early onset myocardial infarction (MI), modified the association of LC n-3 PUFAs with nonfatal MI risk in Costa Rican Hispanics.<b>Design:</b> We analyzed cross-sectional data from 1932 case subjects with a first nonfatal MI and 2055 population-based control subjects who were living in Costa Rica to examine potential gene-environment interactions.
|
28330911 |
2017 |
|
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Although PCSK9 r</span>s11206510 was not associated with hypertension</span>, our study confirms its association with serum cholesterol levels.
|
26266351 |
2015 |
|
Atrial Fibrillation
|
|
0.010 |
GeneticVariation
|
BEFREE |
We observed suggestive associations with the diabetes risk variant rs7961581 (p = 0.038; between TSPAN8 and LGR5) and rs5215 (p = 0.043; KCNJ11), the LDL risk variant rs11206510 (p = 0.045; PCSK9), as well as the AF risk locus ZFHX3.
|
24135527 |
2013 |
|
Diabetes Mellitus
|
|
0.010 |
GeneticVariation
|
BEFREE |
We observed suggestive associations with the diabetes risk variant rs7961581 (p = 0.038; between TSPAN8 and LGR5) and rs5215 (p = 0.043; KCNJ11), the LDL risk variant rs11206510 (p = 0.045; PCSK9), as well as the AF risk locus ZFHX3.
|
24135527 |
2013 |
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
We observed suggestive associations with the diabetes risk variant rs7961581 (p = 0.038; between TSPAN8 and LGR5) and rs5215 (p = 0.043; KCNJ11), the LDL risk variant rs11206510 (p = 0.045; PCSK9), as well as the AF risk locus ZFHX3.
|
24135527 |
2013 |
|
Ischemic stroke
|
|
0.010 |
GeneticVariation
|
BEFREE |
For the first time to our knowledge, this study also demonstrates that rs11206510 confers a significant risk of ischemic stroke.
|
20576952 |
2010 |