|
Blood Pressure
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
|
21909110 |
2011 |
|
Blood Pressure
|
|
0.700 |
GeneticVariation
|
GWASDB |
Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.
|
21572416 |
2011 |
|
Blood Pressure
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genome-wide association study meta-analysis reveals transethnic replication of mean arterial and pulse pressure loci.
|
24001895 |
2013 |
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
Three gene variants, rs12229654, rs17249754, and rs11066280, were significantly associated with metabolic disorders such as hyperlipidemia and diabetes (P = 0.00071 to 0.0097, respectively).
|
24142389 |
2014 |
|
Diabetes Mellitus
|
|
0.010 |
GeneticVariation
|
BEFREE |
Three gene variants, rs12229654, rs17249754, and rs11066280, were significantly associated with metabolic disorders such as hyperlipidemia and diabetes (P = 0.00071 to 0.0097, respectively).
|
24142389 |
2014 |
|
Diastolic blood pressure
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney.
|
28739976 |
2017 |
|
Diastolic blood pressure
|
|
0.700 |
GeneticVariation
|
GWASCAT |
A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure.
|
29455858 |
2018 |
|
Diastolic blood pressure
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension.
|
25249183 |
2015 |
|
Diastolic blood pressure
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.
|
21572416 |
2011 |
|
Diastolic blood pressure
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Interethnic analyses of blood pressure loci in populations of East Asian and European descent.
|
30487518 |
2018 |
|
Diastolic blood pressure
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.
|
26390057 |
2015 |
|
Essential Hypertension
|
|
0.020 |
GeneticVariation
|
BEFREE |
Chi-squared test, logistic regression, and propensity score analysis showed that rs17249754 was associated with EHT, particularly in females.
|
26933664 |
2016 |
|
Essential Hypertension
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results confirmed the significant association of ATP2B1 rs17249754 with the risk of developing EH in Burkinabe and showed an increase of cardiovascular risk markers levels in subjects with EH.
|
31242870 |
2019 |
|
Hyperlipidemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Three gene variants, rs12229654, rs17249754, and rs11066280, were significantly associated with metabolic disorders such as hyperlipidemia and diabetes (P = 0.00071 to 0.0097, respectively).
|
24142389 |
2014 |
|
Hypertensive disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
In conclusion, people with the major allele of ATP2B1 rs17249754 are susceptible to hypertension especially in low intake of Ca and high ratio of Na and K.
|
28934190 |
2017 |
|
Hypertensive disease
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension.
|
25249183 |
2015 |
|
Hypertensive disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
All studies evaluating the association between rs2681472 (rs17249754 or rs11105378) and hypertension risk in East Asians were included.
|
22229515 |
2012 |
|
Hypertensive disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
That is, carriers with ATP2B1 rs17249754 homozygote mutant allele may be at higher risk of hypertension, when they consume excessive sodium intake.
|
27149052 |
2016 |
|
Hypertensive disease
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Interethnic analyses of blood pressure loci in populations of East Asian and European descent.
|
30487518 |
2018 |
|
Hypertensive disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
The MDR analysis demonstrated that the interaction of rs2070759, rs17249754, TC, TG, and BMI increased the susceptibility to hypertension.
|
26933664 |
2016 |
|
Hypertensive disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
We also observed a significant association of 4 SNPs and the GRS with hypertension (ATP2B1 rs17249754: P = 0.02; CSK rs1378942: P = 0.02; CYP17A1 rs1004467: P = 0.02; MTHFR rs1801133: P = 0.03; GRS: P = 0.0004).
|
23591986 |
2013 |
|
Hypertensive disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
An additional hypertension case-control study confirmed that rs17249754 (in ATP2B1) increases hypertension risk in both the KARE and Health2 (meta-analysis, P-value=4.25 x 10(-9)) cohorts.
|
19960030 |
2010 |
|
Hypertensive disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
In contrast, in inactive group, two polymorphisms and genetic risk score were significantly associated with SBP (rs17249754: β = 1.26, 95% confidence interval (CI) 0.61-1.90, p < 0.001; rs1004467: β = 0.68, 95%CI 0.03-1.32, p = 0.039; genetic risk score: β = 1.54, 95%CI 0.74-2.33, p < 0.001); three polymorphisms and genetic risk score were significantly associated with hypertension (rs17249754: odds ratio (OR) = 1.27, 95%CI 1.08-1.49, p = 0.004; rs1378942: OR = 1.25, 95%CI 1.00-1.57, p = 0.050 (marginally significant); rs16998073: OR = 1.17, 95%CI 1.01-1.37, p = 0.044; genetic risk score: OR = 1.38, 95%CI 1.13-1.68, p = 0.001).
|
23102448 |
2012 |
|
Hypertensive disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
The present study confirmed the significant association of ATP2B1 rs17249754 with risk of hypertension among Chinese children, but failed to replicate the association of CSK rs1378942, MTHFR rs1801133, CYP17A1 rs1004467, STK39 rs3754777 and FGF5 rs16998073 with BP/risk of hypertension.
|
23759979 |
2014 |
|
Hypertensive disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
The major findings of this study were that four loci--rs10858911, rs2681472, rs17249754 and rs1401982--associated with any or all of four traits: hypertension (P = 0.001-4.6E-05; odds ratio, 0.83-0.87), systolic BP (P = 0.003-0.004), diastolic BP (P = 0.002-0.003) and cf-PWV (P = 0.002-0.004).
|
23079715 |
2013 |