|
Waist-Hip Ratio
|
|
0.700 |
GeneticVariation
|
GWASDB |
A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits.
|
19396169 |
2009 |
|
Systolic Pressure
|
|
0.700 |
GeneticVariation
|
GWASCAT |
For systolic blood pressure, the most compelling association involved chromosome 12q21 and variants near the ATP2B1 gene (rs17249754, P = 1.3 x 10(-7)).
|
19396169 |
2009 |
|
Hypertensive disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
An additional hypertension case-control study confirmed that rs17249754 (in ATP2B1) increases hypertension risk in both the KARE and Health2 (meta-analysis, P-value=4.25 x 10(-9)) cohorts.
|
19960030 |
2010 |
|
Systolic Pressure
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.
|
21572416 |
2011 |
|
Diastolic blood pressure
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.
|
21572416 |
2011 |
|
Blood Pressure
|
|
0.700 |
GeneticVariation
|
GWASDB |
Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.
|
21572416 |
2011 |
|
Blood Pressure
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
|
21909110 |
2011 |
|
Mean blood pressure
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
|
21909110 |
2011 |
|
Systolic blood pressure measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
|
21909115 |
2011 |
|
Hypertensive disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
All studies evaluating the association between rs2681472 (rs17249754 or rs11105378) and hypertension risk in East Asians were included.
|
22229515 |
2012 |
|
Hypertensive disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
The major findings of this study were that four loci--rs10858911, rs2681472, rs17249754 and rs1401982--associated with any or all of four traits: hypertension (P = 0.001-4.6E-05; odds ratio, 0.83-0.87), systolic BP (P = 0.003-0.004), diastolic BP (P = 0.002-0.003) and cf-PWV (P = 0.002-0.004).
|
23079715 |
2013 |
|
Hypertensive disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
In contrast, in inactive group, two polymorphisms and genetic risk score were significantly associated with SBP (rs17249754: β = 1.26, 95% confidence interval (CI) 0.61-1.90, p < 0.001; rs1004467: β = 0.68, 95%CI 0.03-1.32, p = 0.039; genetic risk score: β = 1.54, 95%CI 0.74-2.33, p < 0.001); three polymorphisms and genetic risk score were significantly associated with hypertension (rs17249754: odds ratio (OR) = 1.27, 95%CI 1.08-1.49, p = 0.004; rs1378942: OR = 1.25, 95%CI 1.00-1.57, p = 0.050 (marginally significant); rs16998073: OR = 1.17, 95%CI 1.01-1.37, p = 0.044; genetic risk score: OR = 1.38, 95%CI 1.13-1.68, p = 0.001).
|
23102448 |
2012 |
|
Hypertensive disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
We also observed a significant association of 4 SNPs and the GRS with hypertension (ATP2B1 rs17249754: P = 0.02; CSK rs1378942: P = 0.02; CYP17A1 rs1004467: P = 0.02; MTHFR rs1801133: P = 0.03; GRS: P = 0.0004).
|
23591986 |
2013 |
|
Hypertensive disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
The present study confirmed the significant association of ATP2B1 rs17249754 with risk of hypertension among Chinese children, but failed to replicate the association of CSK rs1378942, MTHFR rs1801133, CYP17A1 rs1004467, STK39 rs3754777 and FGF5 rs16998073 with BP/risk of hypertension.
|
23759979 |
2014 |
|
Blood Pressure
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genome-wide association study meta-analysis reveals transethnic replication of mean arterial and pulse pressure loci.
|
24001895 |
2013 |
|
Mean blood pressure
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association study meta-analysis reveals transethnic replication of mean arterial and pulse pressure loci.
|
24001895 |
2013 |
|
Hypertensive disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
Five gene variants, rs11066280 (C12orf51), rs12229654 and rs3782889 (MYL2), rs2072134 (OAS3), rs2093395 (TREML2), and rs17249754 (ATP2B1), were found to be associated with hypertension mostly in men (P = 4.76 × 10(-14) to 4.46 × 10(-7) in the joint analysis); three SNPs (rs11066280, rs12229654, and rs3782889) remained significant after Bonferroni correction in an independent population.
|
24142389 |
2014 |
|
Hyperlipidemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Three gene variants, rs12229654, rs17249754, and rs11066280, were significantly associated with metabolic disorders such as hyperlipidemia and diabetes (P = 0.00071 to 0.0097, respectively).
|
24142389 |
2014 |
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
Three gene variants, rs12229654, rs17249754, and rs11066280, were significantly associated with metabolic disorders such as hyperlipidemia and diabetes (P = 0.00071 to 0.0097, respectively).
|
24142389 |
2014 |
|
Diabetes Mellitus
|
|
0.010 |
GeneticVariation
|
BEFREE |
Three gene variants, rs12229654, rs17249754, and rs11066280, were significantly associated with metabolic disorders such as hyperlipidemia and diabetes (P = 0.00071 to 0.0097, respectively).
|
24142389 |
2014 |
|
Metabolic Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
Three gene variants, rs12229654, rs17249754, and rs11066280, were significantly associated with metabolic disorders such as hyperlipidemia and diabetes (P = 0.00071 to 0.0097, respectively).
|
24142389 |
2014 |
|
Hypertensive disease
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension.
|
25249183 |
2015 |
|
Systolic Pressure
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension.
|
25249183 |
2015 |
|
Diastolic blood pressure
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension.
|
25249183 |
2015 |
|
Mean blood pressure
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.
|
26390057 |
2015 |