|
Waist-Hip Ratio
|
|
0.700 |
GeneticVariation
|
GWASDB |
A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits.
|
19396169 |
2009 |
|
Systolic Pressure
|
|
0.700 |
GeneticVariation
|
GWASCAT |
A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure.
|
29455858 |
2018 |
|
Diastolic blood pressure
|
|
0.700 |
GeneticVariation
|
GWASCAT |
A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure.
|
29455858 |
2018 |
|
Hypertensive disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
All studies evaluating the association between rs2681472 (rs17249754 or rs11105378) and hypertension risk in East Asians were included.
|
22229515 |
2012 |
|
Hypertensive disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
An additional hypertension case-control study confirmed that rs17249754 (in ATP2B1) increases hypertension risk in both the KARE and Health2 (meta-analysis, P-value=4.25 x 10(-9)) cohorts.
|
19960030 |
2010 |
|
Essential Hypertension
|
|
0.020 |
GeneticVariation
|
BEFREE |
Chi-squared test, logistic regression, and propensity score analysis showed that rs17249754 was associated with EHT, particularly in females.
|
26933664 |
2016 |
|
Hypertensive disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
Five gene variants, rs11066280 (C12orf51), rs12229654 and rs3782889 (MYL2), rs2072134 (OAS3), rs2093395 (TREML2), and rs17249754 (ATP2B1), were found to be associated with hypertension mostly in men (P = 4.76 × 10(-14) to 4.46 × 10(-7) in the joint analysis); three SNPs (rs11066280, rs12229654, and rs3782889) remained significant after Bonferroni correction in an independent population.
|
24142389 |
2014 |
|
Systolic Pressure
|
|
0.700 |
GeneticVariation
|
GWASCAT |
For systolic blood pressure, the most compelling association involved chromosome 12q21 and variants near the ATP2B1 gene (rs17249754, P = 1.3 x 10(-7)).
|
19396169 |
2009 |
|
Systolic blood pressure measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
|
21909115 |
2011 |
|
Blood Pressure
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
|
21909110 |
2011 |
|
Mean blood pressure
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
|
21909110 |
2011 |
|
Hypertensive disease
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension.
|
25249183 |
2015 |
|
Systolic Pressure
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension.
|
25249183 |
2015 |
|
Diastolic blood pressure
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension.
|
25249183 |
2015 |
|
Blood Pressure
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genome-wide association study meta-analysis reveals transethnic replication of mean arterial and pulse pressure loci.
|
24001895 |
2013 |
|
Mean blood pressure
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association study meta-analysis reveals transethnic replication of mean arterial and pulse pressure loci.
|
24001895 |
2013 |
|
Hypertensive disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
In conclusion, people with the major allele of ATP2B1 rs17249754 are susceptible to hypertension especially in low intake of Ca and high ratio of Na and K.
|
28934190 |
2017 |
|
Hypertensive disease
|
|
0.800 |
GeneticVariation
|
BEFREE |
In contrast, in inactive group, two polymorphisms and genetic risk score were significantly associated with SBP (rs17249754: β = 1.26, 95% confidence interval (CI) 0.61-1.90, p < 0.001; rs1004467: β = 0.68, 95%CI 0.03-1.32, p = 0.039; genetic risk score: β = 1.54, 95%CI 0.74-2.33, p < 0.001); three polymorphisms and genetic risk score were significantly associated with hypertension (rs17249754: odds ratio (OR) = 1.27, 95%CI 1.08-1.49, p = 0.004; rs1378942: OR = 1.25, 95%CI 1.00-1.57, p = 0.050 (marginally significant); rs16998073: OR = 1.17, 95%CI 1.01-1.37, p = 0.044; genetic risk score: OR = 1.38, 95%CI 1.13-1.68, p = 0.001).
|
23102448 |
2012 |
|
Hypertensive disease
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Interethnic analyses of blood pressure loci in populations of East Asian and European descent.
|
30487518 |
2018 |
|
Mean blood pressure
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Interethnic analyses of blood pressure loci in populations of East Asian and European descent.
|
30487518 |
2018 |
|
Systolic Pressure
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Interethnic analyses of blood pressure loci in populations of East Asian and European descent.
|
30487518 |
2018 |
|
Diastolic blood pressure
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Interethnic analyses of blood pressure loci in populations of East Asian and European descent.
|
30487518 |
2018 |
|
Systolic Pressure
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.
|
21572416 |
2011 |
|
Diastolic blood pressure
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.
|
21572416 |
2011 |
|
Blood Pressure
|
|
0.700 |
GeneticVariation
|
GWASDB |
Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.
|
21572416 |
2011 |