|
Crohn Disease
|
|
0.720 |
GeneticVariation
|
BEFREE |
The impact of CD40 rs1883832 on MS and CD risk points to a common signaling shared by these autoimmune conditions.
|
20634952 |
2010 |
|
Crohn Disease
|
|
0.720 |
GeneticVariation
|
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
Genital ulcers
|
|
0.010 |
GeneticVariation
|
BEFREE |
Also, we have found significantly higher frequencies of CC genotype and C allele of CD40 rs1883832 polymorphism in patients with genital ulcers (p < 0.05 for both, OR 2.30, 95 % CI 1.07-4.94 and OR 1.78, 95 % CI 1.06-2.97, respectively).
|
25373542 |
2015 |
|
Giant Cell Arteritis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results suggest a potential implication of the CD40 rs1883832 C/T polymorphism in susceptibility to visual ischemic manifestations in individuals with biopsy-proven GCA.
|
20682661 |
2010 |
|
Giant Cell Arteritis
|
|
0.020 |
GeneticVariation
|
BEFREE |
CD40 rs1883832 is associated with decreased risk of Graves' disease, especially in Asian; CD40 rs1883832 is associated with increased risk of multiple sclerosis; CD40 -1C>T (rs1883832) is not associated with the susceptibility of Hashimoto's thyroiditis, systemic sclerosis or Asthma; there is insufficient data to fully confirm the association between CD40 rs1883832 and systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Behçet's disease (BD), myasthenia gravis (MG), Crohn's disease (CD), ulcerative colitis (UC), Sarcoidosis, Fuch uveitis syndrome (FUS), Vogt-Koyanagi-Harada syndrome (VKH), Kawasaki disease (KD), giant cell arteritis (GCA) or Immune thrombocytopenia (ITP).
|
29254239 |
2017 |
|
Graves Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Genotypic and allelic frequencies of SNP rs231775, rs3087243 and rs1883832 were statistically different between controls and G</span>D (p < 0.05).
|
30223781 |
2018 |
|
Graves Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
In Caucasians, rs1883832 was associated with GD risk under the dominant model (CT + TT vs CC, OR=0.82, 95 % CI: 0.68-0.99, P=0.042).
|
30956635 |
2019 |
|
Graves Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
CD40 rs1883832 is associated with decreased risk of Graves' disease, especially in Asian; CD40 rs1883832 is associated with increased risk of multiple sclerosis; CD40 -1C>T (rs1883832) is not associated with the susceptibility of Hashimoto's thyroiditis, systemic sclerosis or Asthma; there is insufficient data to fully confirm the association between CD40 rs1883832 and systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Behçet's disease (BD), myasthenia gravis (MG), Crohn's disease (CD), ulcerative colitis (UC), Sarcoidosis, Fuch uveitis syndrome (FUS), Vogt-Koyanagi-Harada syndrome (VKH), Kawasaki disease (KD), giant cell arteritis (GCA) or Immune thrombocytopenia (ITP).
|
29254239 |
2017 |
|
Hepatitis B, Chronic
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genetic variants in five novel loci including CFB and CD40 predispose to chronic hepatitis B.
|
25802187 |
2015 |
|
Hepatitis C
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addition, the results of the cumulative effects showed a tendency of that the more risk alleles (rs1535045 T and rs1883832 T) subjects carried, the more possibility of HCV infection exhibited (P<0.001).
|
31615434 |
2019 |
|
Immune thrombocytopenic purpura
|
|
0.010 |
GeneticVariation
|
BEFREE |
CD40 rs1883832 is associated with decreased risk of Graves' disease, especially in Asian; CD40 rs1883832 is associated with increased risk of multiple sclerosis; CD40 -1C>T (rs1883832) is not associated with the susceptibility of Hashimoto's thyroiditis, systemic sclerosis or Asthma; there is insufficient data to fully confirm the association between CD40 rs1883832 and systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Behçet's disease (BD), myasthenia gravis (MG), Crohn's disease (CD), ulcerative colitis (UC), Sarcoidosis, Fuch uveitis syndrome (FUS), Vogt-Koyanagi-Harada syndrome (VKH), Kawasaki disease (KD), giant cell arteritis (GCA) or Immune thrombocytopenia (ITP).
|
29254239 |
2017 |
|
Ischemic stroke
|
|
0.030 |
GeneticVariation
|
BEFREE |
The rs1883832 polymorphism may exert influences on abnormal CD40 expression in IS patients among the Chinese population.
|
28590502 |
2019 |
|
Ischemic stroke
|
|
0.030 |
GeneticVariation
|
BEFREE |
CD40-1C>T polymorphism (rs1883832) is associated with brain vessel reocclusion after fibrinolysis in ischemic stroke.
|
20504251 |
2010 |
|
Ischemic stroke
|
|
0.030 |
GeneticVariation
|
BEFREE |
This meta-analysis provided evidence of association of rs1883832 C allele with an overall increased risk of atherosclerosis but distinct effect of C allele on CAD (including ACS) and IS in Chinese population, respectively.
|
24828072 |
2014 |
|
Lupus Erythematosus, Systemic
|
|
0.060 |
GeneticVariation
|
BEFREE |
Moreover, genotypes carrying the CD40 rs1883832 C/T variant allele were associated with increased CD40 levels compared to the homozygous wild-type genotype in patients with SLE.
|
26474561 |
2015 |
|
Lupus Erythematosus, Systemic
|
|
0.060 |
GeneticVariation
|
BEFREE |
The study did not prove CD40 gene (rs1883832 C/T) polymorphism as a clear risk factor of SLE in this cohort of Egyptian patients, though it was highly likely associated with the carriers of T allele.
|
30374748 |
2019 |
|
Lupus Erythematosus, Systemic
|
|
0.060 |
GeneticVariation
|
BEFREE |
CD40 rs1883832 is associated with decreased risk of Graves' disease, especially in Asian; CD40 rs1883832 is associated with increased risk of multiple sclerosis; CD40 -1C>T (rs1883832) is not associated with the susceptibility of Hashimoto's thyroiditis, systemic sclerosis or Asthma; there is insufficient data to fully confirm the association between CD40 rs1883832 and systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Behçet's disease (BD), myasthenia gravis (MG), Crohn's disease (CD), ulcerative colitis (UC), Sarcoidosis, Fuch uveitis syndrome (FUS), Vogt-Koyanagi-Harada syndrome (VKH), Kawasaki disease (KD), giant cell arteritis (GCA) or Immune thrombocytopenia (ITP).
|
29254239 |
2017 |
|
Lupus Erythematosus, Systemic
|
|
0.060 |
GeneticVariation
|
BEFREE |
The association of CD40 polymorphism (rs1883832C/T) and soluble CD40 with the risk of systemic lupus erythematosus among Egyptian patients.
|
30374748 |
2019 |
|
Lupus Erythematosus, Systemic
|
|
0.060 |
GeneticVariation
|
BEFREE |
There were significant differences in the genotype and allele frequencies of CD40 gene rs1883832C/T polymorphism between the group of patients with SLE and the control group (P < 0.05). sCD40 levels were increased in patients with SLE compared with controls (P < 0.01).
|
26474561 |
2015 |
|
Lupus Erythematosus, Systemic
|
|
0.060 |
GeneticVariation
|
BEFREE |
This study aimed to evaluate the association of CD40 polymorphisms (-1 C > T, rs1883832 and 6,048 G > T, rs4810485) with SLE susceptibility, as well as with mRNA expression and soluble CD40 (sCD40) levels.
|
31642196 |
2019 |
|
Lupus Erythematosus, Systemic
|
|
0.060 |
GeneticVariation
|
BEFREE |
Furthermore, a significant association was reported between systemic lupus erythematosus and the C allele of <i>CD40</i> rs1883832 polymorphism (odds ratio = 1.235, 95% confidence interval = 1.087-1.405, <i>p</i> = 0.001) and A allele of <i>CD40</i> rs3765456 polymorphism and systemic lupus erythematosus in Asians (odds ratio = 1.184, 95% confidence interval = 1.040-1.348, <i>p</i> = 0.011). sCD40 and sCD40L levels were significantly higher in SLE than in controls (standardized mean difference = 1.564, 95% confidence interval = 0.256-2.872, <i>p</i> = 0.019 and standardized mean difference = 1.499, 95% confidence interval = 1.031-1.967, <i>p</i> < 0.001, respectively).
|
31570051 |
2019 |
|
Lupus Erythematosus, Systemic
|
|
0.060 |
GeneticVariation
|
BEFREE |
The rs1883832 C/T polymorphism of CD40 and its sCD40 levels were associated with SLE in the Chinese population.
|
26289938 |
2016 |
|
Lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We hypothesized that single nucleotide polymorphisms (SNPs) in TNFRSF5 and TNFSF5 encoding the CD40 and CD154 proteins, respectively, influence lymphoma risk, particularly a functional TNFRSF5 SNP (-1C>T, rs1883832) associated with reduced B-cell CD40 expression.
|
18287517 |
2008 |
|
Lymphoma, Follicular
|
|
0.010 |
GeneticVariation
|
BEFREE |
Data from earlier studies that are part of this pooling study implicate a functional polymorphism (-1C>T, rs1883832) in the TNFRSF5 gene encoding CD40 in the etiology of follicular lymphoma.
|
20473910 |
2011 |
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addition, our haplotype analysis indicated that the haplotype C(rs1883832)G(rs4810485), which was located within the only linkage disequilibrium (LD) block identified, was a protective haplotype for breast cancer, whereas T(rs1883832)T(rs4810485) increased the risk in the studied population, even after correcting the P value for multiple testing (P = 0.0337 and 0.0430, respectively).
|
21912605 |
2011 |