|
Ischemic stroke
|
|
0.030 |
GeneticVariation
|
BEFREE |
CD40-1C>T polymorphism (rs1883832) is associated with brain vessel reocclusion after fibrinolysis in ischemic stroke.
|
20504251 |
2010 |
|
Lymphoma, Follicular
|
|
0.010 |
GeneticVariation
|
BEFREE |
Data from earlier studies that are part of this pooling study implicate a functional polymorphism (-1C>T, rs1883832) in the TNFRSF5 gene encoding CD40 in the etiology of follicular lymphoma.
|
20473910 |
2011 |
|
Rheumatoid Arthritis
|
|
0.730 |
GeneticVariation
|
BEFREE |
Data from our pilot study indicate a potential association of rs1883832 CD40 gene polymorphism with susceptibility to RA.
|
23166616 |
2012 |
|
Multiple Sclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
From our analysis, we can speculate that the association between rs1883832 and MS was induced by LD, whereas rs6074022 was a marker in stronger LD with the functional variant or was the functional variant itself.
|
23613777 |
2013 |
|
Lupus Erythematosus, Systemic
|
|
0.060 |
GeneticVariation
|
BEFREE |
Furthermore, a significant association was reported between systemic lupus erythematosus and the C allele of <i>CD40</i> rs1883832 polymorphism (odds ratio = 1.235, 95% confidence interval = 1.087-1.405, <i>p</i> = 0.001) and A allele of <i>CD40</i> rs3765456 polymorphism and systemic lupus erythematosus in Asians (odds ratio = 1.184, 95% confidence interval = 1.040-1.348, <i>p</i> = 0.011). sCD40 and sCD40L levels were significantly higher in SLE than in controls (standardized mean difference = 1.564, 95% confidence interval = 0.256-2.872, <i>p</i> = 0.019 and standardized mean difference = 1.499, 95% confidence interval = 1.031-1.967, <i>p</i> < 0.001, respectively).
|
31570051 |
2019 |
|
Hepatitis B, Chronic
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genetic variants in five novel loci including CFB and CD40 predispose to chronic hepatitis B.
|
25802187 |
2015 |
|
Graves Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Genotypic and allelic frequencies of SNP rs231775, rs3087243 and rs1883832 were statistically different between controls and G</span>D (p < 0.05).
|
30223781 |
2018 |
|
Multiple Sclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Genotyping of rs1883832C>T was performed in 1564 MS, 1102 CD and 969 ulcerative colitis (UC) Spanish patients and in 2948 ethnically matched controls by TaqMan chemistry.
|
20634952 |
2010 |
|
Ulcerative Colitis
|
|
0.720 |
GeneticVariation
|
BEFREE |
Genotyping of rs1883832C>T was performed in 1564 MS, 1102 CD and 969 ulcerative colitis (UC) Spanish patients and in 2948 ethnically matched controls by TaqMan chemistry.
|
20634952 |
2010 |
|
Sarcoidosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Genotyping of rs1883832 in 175 Japanese patients with sarcoidosis and 150 age- and sex-matched controls revealed no significant difference between the genotypes of the patient and control groups (CC/CT/TT, 32.8/52.0/14.7% in the patients; 37.3/48.0/14.7% in the controls, P = 0.66; allele C, 59.1% in the patients, 61.3% in the controls, P = 0.57).
|
22077624 |
2011 |
|
Rheumatoid Arthritis
|
|
0.730 |
GeneticVariation
|
GWASCAT |
High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci.
|
24532676 |
2015 |
|
Atherosclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Homozygosity for the C allele of the -1T>C SNP of the CD40 gene (rs1883832) results in an enhanced CD40 surface abundance and pro-inflammatory phenotype of vascular endothelial cells, increasing the susceptibility to atherosclerosis and CHD in humans.This appears to be compensated by an enhanced shedding of sCD40 from the endothelial cell membrane to neutralize excess CD40 ligand. sCD40 might be a potential new biomarker for the pro-inflammatory processes occurring in atherosclerosis.
|
31373353 |
2019 |
|
Arteriosclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Homozygosity for the C allele of the -1T>C SNP of the CD40 gene (rs1883832) results in an enhanced CD40 surface abundance and pro-inflammatory phenotype of vascular endothelial cells, increasing the susceptibility to atherosclerosis and CHD in humans.This appears to be compensated by an enhanced shedding of sCD40 from the endothelial cell membrane to neutralize excess CD40 ligand. sCD40 might be a potential new biomarker for the pro-inflammatory processes occurring in atherosclerosis.
|
31373353 |
2019 |
|
Coronary heart disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Homozygosity for the C allele of the -1T>C SNP of the CD40 gene (rs1883832) results in an enhanced CD40 surface abundance and pro-inflammatory phenotype of vascular endothelial cells, increasing the susceptibility to atherosclerosis and CHD in humans.This appears to be compensated by an enhanced shedding of sCD40 from the endothelial cell membrane to neutralize excess CD40 ligand. sCD40 might be a potential new biomarker for the pro-inflammatory processes occurring in atherosclerosis.
|
31373353 |
2019 |
|
Hepatitis C
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addition, the results of the cumulative effects showed a tendency of that the more risk alleles (rs1535045 T and rs1883832 T) subjects carried, the more possibility of HCV infection exhibited (P<0.001).
|
31615434 |
2019 |
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addition, our haplotype analysis indicated that the haplotype C(rs1883832)G(rs4810485), which was located within the only linkage disequilibrium (LD) block identified, was a protective haplotype for breast cancer, whereas T(rs1883832)T(rs4810485) increased the risk in the studied population, even after correcting the P value for multiple testing (P = 0.0337 and 0.0430, respectively).
|
21912605 |
2011 |
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addition, our haplotype analysis indicated that the haplotype C(rs1883832)G(rs4810485), which was located within the only linkage disequilibrium (LD) block identified, was a protective haplotype for breast cancer, whereas T(rs1883832)T(rs4810485) increased the risk in the studied population, even after correcting the P value for multiple testing (P = 0.0337 and 0.0430, respectively).
|
21912605 |
2011 |
|
Graves Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
In Caucasians, rs1883832 was associated with GD risk under the dominant model (CT + TT vs CC, OR=0.82, 95 % CI: 0.68-0.99, P=0.042).
|
30956635 |
2019 |
|
Lupus Erythematosus, Systemic
|
|
0.060 |
GeneticVariation
|
BEFREE |
Moreover, genotypes carrying the CD40 rs1883832 C/T variant allele were associated with increased CD40 levels compared to the homozygous wild-type genotype in patients with SLE.
|
26474561 |
2015 |
|
Neuromyelitis Optica
|
|
0.010 |
GeneticVariation
|
BEFREE |
Other three SNPs showed protections on NMOSD in dominant models (rs6074022, OR = 0.64, 95 % CI 0.42-0.95, P = 0.031; rs1883832, OR = 0.65, 95 % CI 0.43-0.97, P = 0.036; and rs4810485, OR = 0.63, 95 % CI 0.42-0.95, P = 0.029, respectively), but not significantly after Bonferroni corrections for multiple tests.
|
27578014 |
2017 |
|
Migraine Disorders
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our findings showed that in CD40 rs1883832, TC genotype may have a role in migraine susceptibility.
|
30511624 |
2018 |
|
Malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our findings suggest that the CD40 -1C/T SNP (rs1883832) is correlated with the susceptibility to lung cancer in Chinese, and the TT genotype may further increase the risk of lung cancer.
|
26823861 |
2015 |
|
Primary malignant neoplasm of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our findings suggest that the CD40 -1C/T SNP (rs1883832) is correlated with the susceptibility to lung cancer in Chinese, and the TT genotype may further increase the risk of lung cancer.
|
26823861 |
2015 |
|
Carcinoma of lung
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our findings suggest that the CD40 -1C/T SNP (rs1883832) is correlated with the susceptibility to lung cancer in Chinese, and the TT genotype may further increase the risk of lung cancer.
|
26823861 |
2015 |
|
Multiple Sclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Our investigation revealed that CT individuals in rs1883832 locus of CD40 possessed almost 1.5-fold higher risk for MS than CC individuals (OR = 1.44; 95%CI = 1.03-2.1; p = 0.032), while this risk for TT individuals was almost 2.5-fold higher (OR = 2.36; 95%CI = 1.19-4.78; p = 0.014).
|
24912008 |
2014 |