|
Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
However, with respect to AA genotype of rs3761548, we found highly significant association with the advanced stage (T3-4) of the tumor (OR = 3.90; 95% confidence interval (CI) = 1.56-9.70; p = 0.03).
|
24338714 |
2014 |
|
Graves Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Because a single nucleotide polymorphism (SNP) within the FoxP3 gene (rs3761548 in the promoter region) is associated with susceptibility to Graves' disease, this study detected rs3761548 in a hospital-based case-control study.
|
24035934 |
2013 |
|
Vitiligo
|
|
0.020 |
GeneticVariation
|
BEFREE |
Significantly increased vitiligo risk was associated with the rs2232365 GG [odds ratio (OR) 1·68, 95% confidence interval (CI) 1·17-2·39, P = 0·004] and rs3761548 AA (OR 1·82, 95% CI 1·10-3·01, P = 0·033) genotypes compared with the rs2232365 AA and rs3761548 CC genotypes.
|
23582052 |
2013 |
|
Acute Chest Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results showed that single nucleotide polymorphism rs3761548 had association with ACS in Chinese Han population.
|
23299803 |
2013 |
|
Vitiligo
|
|
0.020 |
GeneticVariation
|
BEFREE |
The rs3761548 of FOXP3 gene in our population may be associated with susceptibility to vitiligo because of altered expression.
|
23498308 |
2013 |
|
Autoimmune Diseases
|
|
0.020 |
GeneticVariation
|
BEFREE |
FoxP3 rs3761548 polymorphism predicts autoimmune disease susceptibility: a meta-analysis.
|
23993983 |
2013 |
|
VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding)
|
|
0.020 |
GeneticVariation
|
BEFREE |
The rs3761548 of FOXP3 gene in our population may be associated with susceptibility to vitiligo because of altered expression.
|
23498308 |
2013 |
|
VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding)
|
|
0.020 |
GeneticVariation
|
BEFREE |
Significantly increased vitiligo risk was associated with the rs2232365 GG [odds ratio (OR) 1·68, 95% confidence interval (CI) 1·17-2·39, P = 0·004] and rs3761548 AA (OR 1·82, 95% CI 1·10-3·01, P = 0·033) genotypes compared with the rs2232365 AA and rs3761548 CC genotypes.
|
23582052 |
2013 |
|
Autoimmune Diseases
|
|
0.020 |
GeneticVariation
|
BEFREE |
The rs3761548 polymorphism (-3279 C>A) of FOXP3 gene is associated with several autoimmune disorders.
|
23498308 |
2013 |
|
Autoimmune thyroid disease (AITD)
|
|
0.010 |
GeneticVariation
|
BEFREE |
There was no allelic association of rs3761548 and rs3761549 polymorphisms with AITD susceptibility, albeit a significant difference in genotype distribution with respect to rs3761549.
|
30771152 |
2019 |
|
Crohn Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The variant allele of rs3761548 was increased in male patients with penetrating CD compared to those with non-stricturing, non-penetrating CD.
|
30710380 |
2019 |
|
Prostate carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Evaluation of the genetic variations in position SNP rs3761548</span> revealed that the AA genotype and A allele were more prevalent whereas CC genotype and C allele were less prevalent in PC patients when compared with healthy men (P < 0.01, P < 0.001, P < 0.002 and P < 0.001, respectively).
|
30057362 |
2019 |
|
Hashimoto Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Haplotype analysis revealed an increased frequency of rs3761548 "C"-rs3761549 "T" in HT and GD subjects, thereby associating it with disease predisposition (p = 0.03).
|
30771152 |
2019 |
|
Squamous intraepithelial lesion
|
|
0.010 |
GeneticVariation
|
BEFREE |
The present study evaluated the effects of the rs3761548 and rs2232365 intronic single-nucleotide variants (SNVs) and their haplotypes on HPV infection and SIL diagnosis in HPV-infected and -uninfected women.
|
31177386 |
2019 |
|
Human papilloma virus infection
|
|
0.010 |
GeneticVariation
|
BEFREE |
The homozygous genotype of the rs3761548 variants (A/A) (related to decreased FOXP3 expression) may exert a protective role against HPV infection in women (OR<sub>Aj</sub>: 0.60; 95% CI 0.36-0.99; p = 0.049) and was an independent predictor of protection against HSIL development (OR<sub>Adj</sub>: 0.28; 95% CI 0.11-0.68; p = 0.006).
|
31177386 |
2019 |
|
Malignant neoplasm of prostate
|
|
0.010 |
GeneticVariation
|
BEFREE |
Evaluation of the genetic variations in position SNP rs3761548</span> revealed that the AA genotype and A allele were more prevalent whereas CC genotype and C allele were less prevalent in PC patients when compared with healthy men (P < 0.01, P < 0.001, P < 0.002 and P < 0.001, respectively).
|
30057362 |
2019 |
|
Degenerative polyarthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our findings indicated that the association between FOXP3 rs2232365 polymorphism and knee OA tended to yield negative results but the FOXP3 rs3761548 C allele was associated with elevated risk of OA in Grade 4 knee OA patients in a Turkish population.
|
30168273 |
2018 |
|
Osteoarthritis, Knee
|
|
0.010 |
GeneticVariation
|
BEFREE |
FOXP3 rs3761548 polymorphism is associated with knee osteoarthritis in a Turkish population.
|
30168273 |
2018 |
|
Malignant neoplasm of endometrium
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results suggest that the frequency of the A allele in rs3761548 in patients with EC was significantly lower than that in healthy controls (20.3% vs 26.4%, odds ratio [OR] 0.71, 95% confidence interval [CI]: 0.54-0.93, P = .012), while the heterozygous AC genotype showed a significant protective effect on EC in codominant, dominant, and overdominant models (adjusted OR 0.64, 95% CI: 0.45-0.91, P = .039; OR 0.65, 95% CI: 0.47-0.91, P = .011; OR 0.67, 95% CI: 0.47-0.94, P = .02, respectively), and AA genotype was more frequent in patients with cervical invasion (recessive model: OR 3.55, 95% CI: 1.10-11.44, P = .046).
|
29718856 |
2018 |
|
Peptic Ulcer
|
|
0.010 |
GeneticVariation
|
BEFREE |
The AA genotype and A allele at rs3761548 could represent a risk factor for PU development.
|
29938865 |
2018 |
|
Tumor Cell Invasion
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results suggest that the frequency of the A allele in rs3761548 in patients with EC was significantly lower than that in healthy controls (20.3% vs 26.4%, odds ratio [OR] 0.71, 95% confidence interval [CI]: 0.54-0.93, P = .012), while the heterozygous AC genotype showed a significant protective effect on EC in codominant, dominant, and overdominant models (adjusted OR 0.64, 95% CI: 0.45-0.91, P = .039; OR 0.65, 95% CI: 0.47-0.91, P = .011; OR 0.67, 95% CI: 0.47-0.94, P = .02, respectively), and AA genotype was more frequent in patients with cervical invasion (recessive model: OR 3.55, 95% CI: 1.10-11.44, P = .046).
|
29718856 |
2018 |
|
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
|
|
0.010 |
GeneticVariation
|
BEFREE |
Here, we investigated IL-35 levels and a single nucleotide polymorphism, rs3761548, in FOXP3 gene in Helicobacter pylori-infected patients with peptic ulcer (PU), to clarify possible associations.
|
29938865 |
2018 |
|
Endometrial Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results suggest that the frequency of the A allele in rs3761548 in patients with EC was significantly lower than that in healthy controls (20.3% vs 26.4%, odds ratio [OR] 0.71, 95% confidence interval [CI]: 0.54-0.93, P = .012), while the heterozygous AC genotype showed a significant protective effect on EC in codominant, dominant, and overdominant models (adjusted OR 0.64, 95% CI: 0.45-0.91, P = .039; OR 0.65, 95% CI: 0.47-0.91, P = .011; OR 0.67, 95% CI: 0.47-0.94, P = .02, respectively), and AA genotype was more frequent in patients with cervical invasion (recessive model: OR 3.55, 95% CI: 1.10-11.44, P = .046).
|
29718856 |
2018 |
|
Psoriasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, IL-10 (rs1800896) and FOXP3 (rs3761548) gene polymorphisms were not associated with psoriasis risk.
|
28027921 |
2017 |
|
Pemphigus Foliaceus
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the whole population, rs3761548, rs3761549 and rs2294021 were associated with the susceptibility to PF.
|
28216259 |
2017 |