|
Breast Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
While no significant results were observed in overall and breast cancer groups for rs3761548 (A/C) polymorphisms, the pooled data showed an elevated risk of cancer in variant AA genotypes and A allele for Chinese population (AA vs. AC+CC: OR = 1.61, 95% CI = 1.09, 2.39; AA vs. CC: OR = 1.74, 95% CI = 1.05, 2.89; A vs. C: OR = 1.34, 95% CI = 1.00, 1.78).
|
30782783 |
2019 |
|
Malignant neoplasm of breast
|
|
0.040 |
GeneticVariation
|
BEFREE |
While no significant results were observed in overall and breast cancer groups for rs3761548 (A/C) polymorphisms, the pooled data showed an elevated risk of cancer in variant AA genotypes and A allele for Chinese population (AA vs. AC+CC: OR = 1.61, 95% CI = 1.09, 2.39; AA vs. CC: OR = 1.74, 95% CI = 1.05, 2.89; A vs. C: OR = 1.34, 95% CI = 1.00, 1.78).
|
30782783 |
2019 |
|
Multiple Sclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
The aim of this study was to evaluate the association between rs3761548 FOXP3 (-3279 C > A) variant and multiple sclerosis (MS), disability, disability progression, as well as transforming growth factor (TGF)-β1 and interleukin (IL)-10 plasma levels in MS patients.
|
31414141 |
2019 |
|
Multiple Sclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
FOXP3 gene polymorphism rs3761548 was associated with a higher MS risk, especially in Asians.
|
31567981 |
2019 |
|
Malignant neoplasm of breast
|
|
0.040 |
GeneticVariation
|
BEFREE |
Our study suggests that <i>FOXP3</i> polymorphism rs3761548 is associated with BC susceptibility in the Chinese and may be involved in tumor progression.
|
29731666 |
2018 |
|
Multiple Sclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
The purpose of our study was to evaluate the association of chosen polymorphisms of FOXP3 gene (rs3761549, rs3761548, rs3761547) with different clinical multiple sclerosis (MS) data of our relapsing-remitting groups of patients and in control group.
|
30229436 |
2018 |
|
Breast Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Our study suggests that <i>FOXP3</i> polymorphism rs3761548 is associated with BC susceptibility in the Chinese and may be involved in tumor progression.
|
29731666 |
2018 |
|
Breast Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
In this context, the present study aimed to evaluate the g.10403A>G (rs2232365) polymorphisms and g.8048A>C (rs3761548), in aggressive breast cancer (BC) subtypes, including, Luminal B HER2+ (LB), HER2-enriched (HER2+), and triple-negative (TN).
|
28713192 |
2017 |
|
Malignant neoplasm of breast
|
|
0.040 |
GeneticVariation
|
BEFREE |
In this context, the present study aimed to evaluate the g.10403A>G (rs2232365) polymorphisms and g.8048A>C (rs3761548), in aggressive breast cancer (BC) subtypes, including, Luminal B HER2+ (LB), HER2-enriched (HER2+), and triple-negative (TN).
|
28713192 |
2017 |
|
Multiple Sclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
The frequencies of AA and AC genotypes at rs3761548 in the FOXP3 gene were significantly higher in MS group as compared with healthy subjects (P < 0.05).
|
25326790 |
2015 |
|
Malignant neoplasm of breast
|
|
0.040 |
GeneticVariation
|
BEFREE |
Foxp3 promoter polymorphism (rs3761548) in breast cancer progression: a study from India.
|
24338714 |
2014 |
|
Breast Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Foxp3 promoter polymorphism (rs3761548) in breast cancer progression: a study from India.
|
24338714 |
2014 |
|
Allergic rhinitis (disorder)
|
|
0.030 |
GeneticVariation
|
BEFREE |
In summary, no significant association between rs3761548, rs2232365 polymorphisms of the FOXP3 gene, and an increased susceptibility to allergic rhinitis was identified based on the published data; however, this conclusion should be confirmed by more studies with increased sample sizes.
|
28741671 |
2017 |
|
Allergic rhinitis (disorder)
|
|
0.030 |
GeneticVariation
|
BEFREE |
The diplotype rs3761548-rs4824747 in FOXP3 gene with "AG" was associated with risk of AR (P=0.031, OR=1.755).
|
22836044 |
2012 |
|
Allergic rhinitis (disorder)
|
|
0.030 |
GeneticVariation
|
BEFREE |
The results demonstrated that females homozygous for the rare FOXP3 rs3761548 allele (A/A) are protected against AR; otherwise, females who are either wild types (C/C) or heterozygote carriers (C/A) of the rare allele are more susceptible to AR (OR [95%CI] = 2.089 [1,095; 3.988]).
|
21763379 |
2011 |
|
Primary malignant neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
While no significant results were observed in overall and breast cancer groups for rs3761548 (A/C) polymorphisms, the pooled data showed an elevated risk of cancer in variant AA genotypes and A allele for Chinese population (AA vs. AC+CC: OR = 1.61, 95% CI = 1.09, 2.39; AA vs. CC: OR = 1.74, 95% CI = 1.05, 2.89; A vs. C: OR = 1.34, 95% CI = 1.00, 1.78).
|
30782783 |
2019 |
|
Malignant Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
While no significant results were observed in overall and breast cancer groups for rs3761548 (A/C) polymorphisms, the pooled data showed an elevated risk of cancer in variant AA genotypes and A allele for Chinese population (AA vs. AC+CC: OR = 1.61, 95% CI = 1.09, 2.39; AA vs. CC: OR = 1.74, 95% CI = 1.05, 2.89; A vs. C: OR = 1.34, 95% CI = 1.00, 1.78).
|
30782783 |
2019 |
|
Graves Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
We analyzed the association between CTLA-4 rs231775 and FOXP3 rs3761548, rs3761549 polymorphisms and predisposition to autoimmune thyroid disease (AITD), inclusive of Hashimoto's thyroiditis (HT) and Graves' disease (GD) in South-Indian population.
|
30771152 |
2019 |
|
Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
In addition, CA, CA/AA genotype, and A allele of rs3761548 were related to larger tumor size, and the A allele was also correlated with a positive status of Her-2 in BC patients.
|
29731666 |
2018 |
|
Malignant Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results suggest that rs3761548 polymorphism is associated with cancer risk.
|
30142808 |
2018 |
|
Primary malignant neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results suggest that rs3761548 polymorphism is associated with cancer risk.
|
30142808 |
2018 |
|
Tumor Progression
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our study suggests that <i>FOXP3</i> polymorphism rs3761548 is associated with BC susceptibility in the Chinese and may be involved in tumor progression.
|
29731666 |
2018 |
|
Acute Chest Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
However, rs3761548 C allele was more prevalent in controls compared with patients with ACS (P = 0.024).
|
26931655 |
2016 |
|
Acute Chest Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
In the present study, we analysed the expression of FOXP3 as well as the association between two variants in this gene (rs3761548A/C and rs5902434del/ATT) and occurrence of ACS in Iranian patients.
|
26931655 |
2016 |
|
Tumor Progression
|
|
0.020 |
GeneticVariation
|
BEFREE |
Stratified data also revealed an association of homozygous mutant genotype with advanced stage of tumor in premenopausal women (OR = 4.56; 95% CI = 1.07-19.38; p = 0.04) with disease duration of <6 months (OR = .10; 95% CI = 1.80-20.50; p = 0.002) suggestive of modulating effect of rs3761548 in tumor progression.
|
24338714 |
2014 |