Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 334
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 185
IL6 P05231 interleukin 6 0.32 0.248 0.962 262
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 224
IL10 P22301 interleukin 10 5.9E-03 0.281 0.923 92
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 170
IFNG P01579 interferon gamma 0.47 0.288 0.962 157
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 59
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 99
CRP P02741 C-reactive protein 3.7E-03 0.299 0.962 76
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 96
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885 105
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 145
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 89
BRAF P15056 B-Raf proto-oncogene, serine/threonine kinase Kinase 1.00 0.319 0.846 66
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 128
TLR4 O00206 toll like receptor 4 4.6E-09 0.321 0.962 76
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962 97
CD274 Q9NZQ7 CD274 molecule Receptor 1.9E-02 0.324 0.923 21
ACTB P60709 actin beta Cellular structure 0.99 0.325 0.923 41
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 90
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 Kinase 6.0E-03 0.328 0.923 65
MAPK1 P28482 mitogen-activated protein kinase 1 Kinase 1.00 0.330 0.923 65
IL2 P60568 interleukin 2 0.48 0.336 0.885 73