Source: CURATED

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 340 9
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 232 407
IL6 P05231 interleukin 6 0.32 0.248 0.962 270 4
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 231 5
IL10 P22301 interleukin 10 5.9E-03 0.281 0.923 95 5
IFNG P01579 interferon gamma 0.47 0.288 0.962 167 1
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 141 11
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 98 61
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 124 58
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 115 105
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885 130 54
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 182 355
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 138 9
CXCL8 P10145 C-X-C motif chemokine ligand 8 Signaling 2.7E-04 0.310 0.962 109 1
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 109 7
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 239 0
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885 119 12
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 164 35
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 138 40
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962 113 95
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha Transcription factor 0.98 0.327 0.923 89 2
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 Kinase 6.0E-03 0.328 0.923 83 37
CSF2 P04141 colony stimulating factor 2 Signaling 0.83 0.330 0.962 103 3
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923 98 8