Source: CURATED

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
IL6 P05231 interleukin 6 0.32 0.248 0.962 270 4
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 239 0
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 232 407
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 179 27
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962 113 95
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 109 7
CXCL8 P10145 C-X-C motif chemokine ligand 8 Signaling 2.7E-04 0.310 0.962 109 1
APC P25054 APC regulator of WNT signaling pathway 1.00 0.373 0.962 95 596
TLR4 O00206 toll like receptor 4 4.6E-09 0.321 0.962 80 3
ICAM1 P05362 intercellular adhesion molecule 1 3.5E-02 0.364 0.962 57 9
SOD2 P04179 superoxide dismutase 2 Enzyme 0.15 0.379 0.923 285 1
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 182 355
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923 167 4
KRAS P01116 KRAS proto-oncogene, GTPase Enzyme modulator 7.9E-04 0.320 0.923 164 35
INS P01308 insulin 0.30 0.445 0.923 157 34
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 138 9
STAT3 P40763 signal transducer and activator of transcription 3 Nucleic acid binding 1.00 0.320 0.923 138 40
HMOX1 P09601 heme oxygenase 1 9.7E-03 0.381 0.923 137 3
PLAU P00749 plasminogen activator, urokinase Enzyme 2.3E-06 0.425 0.923 109 3
GSTP1 P09211 glutathione S-transferase pi 1 1.4E-02 0.383 0.923 103 4
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 101 18
AHR P35869 aryl hydrocarbon receptor Transcription factor 1.00 0.410 0.923 99 10
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923 98 61
CCND1 P24385 cyclin D1 Enzyme modulator 0.89 0.344 0.923 96 6