Source: ALL

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
PIK3CD O00329 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Kinase 1.00 0.319 0.885 1119 24
ACTB P60709 actin beta Cellular structure 0.99 0.325 0.923 1110 39
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962 1101 185
PIK3CG P48736 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Kinase 1.4E-06 0.320 0.885 1101 12
PIK3CB P42338 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta Kinase 1.00 0.322 0.885 1083 13
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 1082 82
IL17A Q16552 interleukin 17A 4.3E-02 0.324 0.923 1074 19
MAPK1 P28482 mitogen-activated protein kinase 1 Kinase 1.00 0.330 0.923 1059 13
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962 1049 62
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha Transcription factor 0.98 0.327 0.923 1044 15
SMUG1 Q53HV7 single-strand-selective monofunctional uracil-DNA glycosylase 1 4.5E-04 0.322 0.923 1034 6
CSF2 P04141 colony stimulating factor 2 Signaling 0.83 0.330 0.962 1028 7
MMP2 P08253 matrix metallopeptidase 2 Enzyme 0.84 0.333 0.923 1021 43
HLA-DRB1 P01911 major histocompatibility complex, class II, DR beta 1 Immune response 1.1E-03 0.333 0.923 1018 185
CD274 Q9NZQ7 CD274 molecule Receptor 1.9E-02 0.324 0.923 1011 8
IL1A P01583 interleukin 1 alpha 1.6E-04 0.333 0.962 1002 19
IL4 P05112 interleukin 4 4.7E-03 0.332 0.962 996 23
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 Kinase 6.0E-03 0.328 0.923 995 85
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923 992 56
MTOR P42345 mechanistic target of rapamycin kinase Kinase 1.00 0.343 0.885 960 48
IL2 P60568 interleukin 2 0.48 0.336 0.885 950 5
ABCB1 P08183 ATP binding cassette subfamily B member 1 Transporter 1.3E-05 0.344 0.885 933 59
LEP P41159 leptin 0.46 0.349 0.846 931 15
PPARG P37231 peroxisome proliferator activated receptor gamma Nuclear receptor 2.9E-02 0.358 0.885 877 101