Source: LHGDN

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
AKT1 P31749 AKT serine/threonine kinase 1 Kinase 0.98 0.311 0.962 60
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha Transcription factor 0.98 0.327 0.923 59
GSTP1 P09211 glutathione S-transferase pi 1 1.4E-02 0.383 0.923 58
CTNNB1 P35222 catenin beta 1 1.00 0.303 0.885 53
CXCL12 P48061 C-X-C motif chemokine ligand 12 0.12 0.379 0.846 53
FGF2 P09038 fibroblast growth factor 2 Signaling 1.8E-02 0.383 0.923 53
HMOX1 P09601 heme oxygenase 1 9.7E-03 0.381 0.923 53
CDKN1B P46527 cyclin dependent kinase inhibitor 1B 0.62 0.409 0.769 52
KIT P10721 KIT proto-oncogene, receptor tyrosine kinase Kinase 0.98 0.366 0.808 51
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923 51
BIRC5 O15392 baculoviral IAP repeat containing 5 Enzyme modulator 5.6E-02 0.495 0.731 50
CDH1 P12830 cadherin 1 0.15 0.401 0.808 50
ERBB2 P04626 erb-b2 receptor tyrosine kinase 2 Kinase 6.0E-03 0.328 0.923 50
SPP1 P10451 secreted phosphoprotein 1 2.1E-06 0.353 0.885 50
CXCR4 P61073 C-X-C motif chemokine receptor 4 G-protein coupled receptor 1.8E-02 0.362 0.923 49
MYC P01106 MYC proto-oncogene, bHLH transcription factor Transcription factor 1.00 0.344 0.923 47
PLAU P00749 plasminogen activator, urokinase Enzyme 2.3E-06 0.425 0.923 46
JAK2 O60674 Janus kinase 2 Kinase 0.65 0.385 0.885 45
BAX Q07812 BCL2 associated X, apoptosis regulator Signaling 0.32 0.417 0.885 44
ADM P35318 adrenomedullin Signaling 4.1E-02 0.436 0.808 43
AGER Q15109 advanced glycosylation end-product specific receptor Receptor 6.4E-16 0.420 0.885 42
MET P08581 MET proto-oncogene, receptor tyrosine kinase Kinase 0.97 0.380 0.846 42
F3 P13726 coagulation factor III, tissue factor Receptor 1.9E-02 0.415 0.846 41
MDM2 Q00987 MDM2 proto-oncogene Nucleic acid binding 1.00 0.362 0.846 41