Source: RGD

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
GSK3B P49841 glycogen synthase kinase 3 beta Kinase 0.96 0.430 0.846 26
CYP2E1 P05181 cytochrome P450 family 2 subfamily E member 1 8.1E-09 0.459 0.885 24
HAMP P81172 hepcidin antimicrobial peptide 8.2E-03 0.433 0.846 24
EGR1 P18146 early growth response 1 Nucleic acid binding 0.35 0.433 0.923 23
HMGB1 P09429 high mobility group box 1 Nucleic acid binding 0.82 0.368 0.923 23
NFE2L2 Q16236 nuclear factor, erythroid 2 like 2 Enzyme 3.6E-03 0.357 0.885 23
NGFR P08138 nerve growth factor receptor Receptor 9.8E-02 0.477 0.846 23
TNFRSF1A P19438 TNF receptor superfamily member 1A 0.99 0.409 0.923 23
AQP4 P55087 aquaporin 4 Ion channel 2.3E-03 0.456 0.885 20
SIRT1 Q96EB6 sirtuin 1 Epigenetic regulator 8.7E-02 0.378 0.885 20
IL13 P35225 interleukin 13 1.4E-02 0.386 0.846 18
MAPK1 P28482 mitogen-activated protein kinase 1 Kinase 1.00 0.330 0.923 18
SERPINF1 P36955 serpin family F member 1 Enzyme modulator 7.8E-08 0.460 0.846 18
TH P07101 tyrosine hydroxylase 1.7E-06 0.462 0.885 18
SOD1 P00441 superoxide dismutase 1 Enzyme 0.18 0.379 0.962 17
MAPT P10636 microtubule associated protein tau 6.0E-03 0.446 0.923 16
NFKBIA P25963 NFKB inhibitor alpha 0.99 0.487 0.885 16
PDGFRB P09619 platelet derived growth factor receptor beta Kinase 0.90 0.416 0.846 16
ACE2 Q9BYF1 angiotensin I converting enzyme 2 Enzyme 1.00 0.477 0.769 15
CRH P06850 corticotropin releasing hormone Signaling 0.72 0.439 0.808 15
PLAT P00750 plasminogen activator, tissue type Enzyme 5.7E-05 0.445 0.885 15
SLC9A1 P19634 solute carrier family 9 member A1 Transporter 0.79 0.550 0.731 15
BNIP3 Q12983 BCL2 interacting protein 3 2.0E-05 0.520 0.731 14
ELANE P08246 elastase, neutrophil expressed Enzyme 1.2E-03 0.447 0.846 14