Source: LHGDN

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 226
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923 171
TP53 P04637 tumor protein p53 Transcription factor 0.53 0.236 0.962 169
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962 156
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 149
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 118
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 110
CXCL8 P10145 C-X-C motif chemokine ligand 8 Signaling 2.7E-04 0.310 0.962 100
IFNG P01579 interferon gamma 0.47 0.288 0.962 91
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885 83
FAS P25445 Fas cell surface death receptor 0.81 0.372 0.923 76
NOS2 P35228 nitric oxide synthase 2 4.0E-15 0.364 0.923 67
FASLG P48023 Fas ligand Signaling 0.18 0.430 0.885 66
TERT O14746 telomerase reverse transcriptase Enzyme 0.99 0.374 0.846 66
GSTM1 P09488 glutathione S-transferase mu 1 2.1E-03 0.380 0.923 62
GSTP1 P09211 glutathione S-transferase pi 1 1.4E-02 0.383 0.923 58
GSTT1 P30711 glutathione S-transferase theta 1 1.5E-04 0.393 0.923 55
TNFSF10 P50591 TNF superfamily member 10 Signaling 0.13 0.413 0.885 54
CXCL12 P48061 C-X-C motif chemokine ligand 12 0.12 0.379 0.846 53
FGF2 P09038 fibroblast growth factor 2 Signaling 1.8E-02 0.383 0.923 53
CXCR4 P61073 C-X-C motif chemokine receptor 4 G-protein coupled receptor 1.8E-02 0.362 0.923 49
HLA-G P17693 major histocompatibility complex, class I, G 1.4E-11 0.461 0.769 46
JAK2 O60674 Janus kinase 2 Kinase 0.65 0.385 0.885 45
BAX Q07812 BCL2 associated X, apoptosis regulator Signaling 0.32 0.417 0.885 44