Source: CURATED

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 340 9
SOD2 P04179 superoxide dismutase 2 Enzyme 0.15 0.379 0.923 285 1
IL6 P05231 interleukin 6 0.32 0.248 0.962 270 4
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 239 0
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 231 5
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 192 93
CAT P04040 catalase Enzyme 1.6E-10 0.359 0.962 171 2
VEGFA P15692 vascular endothelial growth factor A Signaling 2.4E-05 0.266 0.923 167 4
IFNG P01579 interferon gamma 0.47 0.288 0.962 167 1
CCL2 P13500 C-C motif chemokine ligand 2 Signaling 0.61 0.321 0.962 151 0
DRD2 P14416 dopamine receptor D2 G-protein coupled receptor 0.75 0.436 0.846 133 7
EGFR P00533 epidermal growth factor receptor Kinase 0.37 0.295 0.885 124 58
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923 119 20
CDKN2A P42771 Q8N726 cyclin dependent kinase inhibitor 2A 0.39 0.300 0.885 115 105
CNR1 P21554 cannabinoid receptor 1 G-protein coupled receptor 0.51 0.446 0.808 115 1
LEP P41159 leptin 0.46 0.349 0.846 114 3
EDN1 P05305 endothelin 1 Signaling 0.46 0.380 0.846 113 9
OXT P01178 oxytocin/neurophysin I prepropeptide Signaling 0.71 0.615 0.423 110 1
NPY P01303 neuropeptide Y Signaling 0.14 0.447 0.846 109 0
CRH P06850 corticotropin releasing hormone Signaling 0.72 0.439 0.808 107 2
PDYN P01213 prodynorphin Signaling 1.7E-04 0.535 0.577 102 7
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 101 18
CCND1 P24385 cyclin D1 Enzyme modulator 0.89 0.344 0.923 96 6
CYP2D6 P10635 cytochrome P450 family 2 subfamily D member 6 1.1E-25 0.437 0.885 93 2