Source: ALL

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962 2724 31
IL6 P05231 interleukin 6 0.32 0.248 0.962 2367 22
IL1B P01584 interleukin 1 beta 0.13 0.276 0.962 1801 22
CRP P02741 C-reactive protein 3.7E-03 0.299 0.962 1483 15
MMP9 P14780 matrix metallopeptidase 9 Enzyme 1.9E-17 0.305 0.923 1337 31
PTGS2 P35354 prostaglandin-endoperoxide synthase 2 Enzyme 1.00 0.314 0.962 1234 27
TLR4 O00206 toll like receptor 4 4.6E-09 0.321 0.962 1174 54
ACE P12821 angiotensin I converting enzyme Enzyme 1.0E-37 0.328 0.923 1082 82
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962 1049 62
IL1A P01583 interleukin 1 alpha 1.6E-04 0.333 0.962 1002 19
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923 992 56
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 985 137
COX2 P00403 cytochrome c oxidase subunit II Enzyme 0.352 0.962 875 79
SPP1 P10451 secreted phosphoprotein 1 2.1E-06 0.353 0.885 824 13
CASP3 P42574 caspase 3 Enzyme 0.10 0.351 0.923 819 26
NLRP3 Q96P20 NLR family pyrin domain containing 3 8.1E-04 0.361 0.962 805 74
SERPINE1 P05121 serpin family E member 1 Enzyme modulator 4.4E-02 0.359 0.885 770 23
IL18 Q14116 interleukin 18 3.1E-02 0.365 0.923 750 18
TLR2 O60603 toll like receptor 2 1.0E-06 0.361 0.923 749 15
MIR21 microRNA 21 0.363 0.846 726 2
HMGB1 P09429 high mobility group box 1 Nucleic acid binding 0.82 0.368 0.923 724 10
MTCO2P12 MT-CO2 pseudogene 12 0.368 0.962 703 0
PLG P00747 plasminogen Enzyme 1.0E-02 0.389 0.923 586 34
LGALS3 P17931 galectin 3 Signaling 2.3E-05 0.392 0.846 557 15