| Gene | Uniprot | Gene Full Name | Protein Class | pLI | DSI g | DPI g | Num. diseases |
|---|---|---|---|---|---|---|---|
| BRCA1 | P38398 | BRCA1 DNA repair associated | Enzyme | 9.2E-29 | 0.367 | 0.923 | 7 |
| BRCA2 | P51587 | BRCA2 DNA repair associated | Nucleic acid binding | 2.4E-25 | 0.379 | 0.846 | 7 |
| HNF1B | P35680 | HNF1 homeobox B | Nucleic acid binding | 1.00 | 0.473 | 0.808 | 7 |
| CHEK2 | O96017 | checkpoint kinase 2 | Kinase | 1.2E-24 | 0.460 | 0.808 | 4 |
| SRD5A2 | P31213 | steroid 5 alpha-reductase 2 | Enzyme | 0.564 | 0.615 | 3 | |
| ELAC2 | Q9BQ52 | elaC ribonuclease Z 2 | 1.7E-20 | 0.670 | 0.346 | 2 | |
| NBN | O60934 | nibrin | Nucleic acid binding | 2.2E-16 | 0.467 | 0.808 | 2 |
| EPHB2 | P29323 | EPH receptor B2 | Kinase | 1.00 | 0.374 | 0.846 | 1 |
| HOXB13 | Q92826 | homeobox B13 | 3.7E-08 | 0.573 | 0.462 | 1 | |
| MSMB | P08118 | microseminoprotein beta | Signaling | 1.6E-02 | 0.498 | 0.846 | 1 |
| MSR1 | P21757 | macrophage scavenger receptor 1 | Enzyme | 2.2E-20 | 0.553 | 0.654 | 1 |
| RNASEL | Q05823 | ribonuclease L | Kinase | 2.0E-10 | 0.579 | 0.692 | 1 |