Source: ORPHANET

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6041
Gene Symbol: RNASEL
RNASEL
CUI: C2931456
Disease: Prostate cancer, familial
Prostate cancer, familial 		0.700 SusceptibilityMutation ORPHANET Many polymorphisms in genes, such as ELAC2 (locus HPC2), RNase L (locus hereditary prostate cancer 1 gene [HPC1]), and MSR1 have been recognized as important genetic factors that confer an increased risk of developing prostate cancer in many populations. 23141781

2013
Entrez Id: 60528
Gene Symbol: ELAC2
ELAC2
CUI: C2931456
Disease: Prostate cancer, familial
Prostate cancer, familial 		0.600 SusceptibilityMutation ORPHANET Many polymorphisms in genes, such as ELAC2 (locus HPC2), RNase L (locus hereditary prostate cancer 1 gene [HPC1]), and MSR1 have been recognized as important genetic factors that confer an increased risk of developing prostate cancer in many populations. 23141781

2013
Entrez Id: 10481
Gene Symbol: HOXB13
HOXB13
CUI: C2931456
Disease: Prostate cancer, familial
Prostate cancer, familial 		0.600 SusceptibilityMutation ORPHANET The novel HOXB13 G84E variant is associated with a significantly increased risk of hereditary prostate cancer. 22236224

2012
Entrez Id: 4481
Gene Symbol: MSR1
MSR1
CUI: C2931456
Disease: Prostate cancer, familial
Prostate cancer, familial 		0.580 SusceptibilityMutation ORPHANET Many polymorphisms in genes, such as ELAC2 (locus HPC2), RNase L (locus hereditary prostate cancer 1 gene [HPC1]), and MSR1 have been recognized as important genetic factors that confer an increased risk of developing prostate cancer in many populations. 23141781

2013
Entrez Id: 4481
Gene Symbol: MSR1
MSR1
CUI: C2931456
Disease: Prostate cancer, familial
Prostate cancer, familial 		0.580 SusceptibilityMutation ORPHANET Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk. 12244320

2002
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C2931456
Disease: Prostate cancer, familial
Prostate cancer, familial 		0.520 SusceptibilityMutation ORPHANET Additional screening for CHEK2 mutations in 149 families with familial prostate cancer revealed 11 mutations (5 unique) in nine families. 12533788

2003
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
CUI: C2931456
Disease: Prostate cancer, familial
Prostate cancer, familial 		0.380 SusceptibilityMutation ORPHANET Rare germline mutations in the BRCA2 gene are associated with early-onset prostate cancer. 17700570

2007
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C2931456
Disease: Prostate cancer, familial
Prostate cancer, familial 		0.360 SusceptibilityMutation ORPHANET Prostate cancer: germline prediction for a commonly variable malignancy. 22974436

2012
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C2931456
Disease: Prostate cancer, familial
Prostate cancer, familial 		0.360 SusceptibilityMutation ORPHANET Cancer Incidence in BRCA1 mutation carriers. 12237281

2002
Entrez Id: 4477
Gene Symbol: MSMB
MSMB
CUI: C2931456
Disease: Prostate cancer, familial
Prostate cancer, familial 		0.320 SusceptibilityMutation ORPHANET Mutation analysis of the MSMB gene in familial prostate cancer. 19997100

2010
Entrez Id: 4477
Gene Symbol: MSMB
MSMB
CUI: C2931456
Disease: Prostate cancer, familial
Prostate cancer, familial 		0.320 SusceptibilityMutation ORPHANET Fine mapping and functional analysis of a common variant in MSMB on chromosome 10q11.2 associated with prostate cancer susceptibility. 19383797

2009
Entrez Id: 4477
Gene Symbol: MSMB
MSMB
CUI: C2931456
Disease: Prostate cancer, familial
Prostate cancer, familial 		0.320 SusceptibilityMutation ORPHANET Multiple newly identified loci associated with prostate cancer susceptibility. 18264097

2008
Entrez Id: 4683
Gene Symbol: NBN
NBN
CUI: C2931456
Disease: Prostate cancer, familial
Prostate cancer, familial 		0.310 SusceptibilityMutation ORPHANET In this study, 94 unrelated familial prostate cancer cases from the University of Michigan Prostate Cancer Genetics Project (n = 54) and Johns Hopkins University (n = 40) were subjected to targeted next-generation sequencing of the exons, including UTRs, of NBN. 22864661

2012
Entrez Id: 2048
Gene Symbol: EPHB2
EPHB2
CUI: C2931456
Disease: Prostate cancer, familial
Prostate cancer, familial 		0.310 SusceptibilityMutation ORPHANET A common nonsense mutation in EphB2 is associated with prostate cancer risk in African American men with a positive family history. 16155194

2006
Entrez Id: 4683
Gene Symbol: NBN
NBN
CUI: C2931456
Disease: Prostate cancer, familial
Prostate cancer, familial 		0.310 SusceptibilityMutation ORPHANET NBS1 is a prostate cancer susceptibility gene. 14973119

2004
Entrez Id: 6716
Gene Symbol: SRD5A2
SRD5A2
CUI: C2931456
Disease: Prostate cancer, familial
Prostate cancer, familial 		0.310 GeneticVariation ORPHANET

Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
CUI: C2931456
Disease: Prostate cancer, familial
Prostate cancer, familial 		0.300 SusceptibilityMutation ORPHANET Chromosome 17q12 variants contribute to risk of early-onset prostate cancer. 18701471

2008