Source: CTD_human

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.400 Biomarker CTD_human Interleukin-8 increases vascular endothelial growth factor and neuropilin expression and stimulates ERK activation in human pancreatic cancer. 18307536

2008
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0205641
Disease: Adenocarcinoma, Basal Cell
Adenocarcinoma, Basal Cell 		0.300 Biomarker CTD_human Interleukin-8 increases vascular endothelial growth factor and neuropilin expression and stimulates ERK activation in human pancreatic cancer. 18307536

2008
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0205642
Disease: Adenocarcinoma, Oxyphilic
Adenocarcinoma, Oxyphilic 		0.300 Biomarker CTD_human Interleukin-8 increases vascular endothelial growth factor and neuropilin expression and stimulates ERK activation in human pancreatic cancer. 18307536

2008
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0205645
Disease: Adenocarcinoma, Tubular
Adenocarcinoma, Tubular 		0.300 Biomarker CTD_human Interleukin-8 increases vascular endothelial growth factor and neuropilin expression and stimulates ERK activation in human pancreatic cancer. 18307536

2008
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0458247
Disease: Allodynia
Allodynia 		0.300 Biomarker CTD_human Pharmacological modulation of secondary mediator systems--cyclic AMP and cyclic GMP--on inflammatory hyperalgesia. 10401557

1999
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0458247
Disease: Allodynia
Allodynia 		0.300 Biomarker CTD_human S14080, a peripheral analgesic acting by release of an endogenous circulating opioid-like substance. 7881729

1995
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C4721507
Disease: Alveolitis, Fibrosing
Alveolitis, Fibrosing 		0.320 Biomarker CTD_human Increased granulocyte-colony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF) levels in BAL fluid from patients with sulfur mustard gas-induced pulmonary fibrosis. 17894541

2007
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C4721507
Disease: Alveolitis, Fibrosing
Alveolitis, Fibrosing 		0.320 Biomarker CTD_human Levels of cytokine in bronchoalveolar lavage (BAL) fluid in patients with pulmonary fibrosis due to sulfur mustard gas inhalation. 17266442

2007
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0151603
Disease: Anasarca
Anasarca 		0.300 Biomarker CTD_human Activation of inflammatory response and apoptosis of polymorphonuclear leukocytes in patients with argemone oil poisoning. 19874808

2010
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0002965
Disease: Angina, Unstable
Angina, Unstable 		0.300 Biomarker CTD_human In unstable angina pectoris increased plasma IL-8 levels were evidenced in 25 of the 35 patients, after an average interval of 20 +/- 1.2 hours from the last spontaneous episode of angina pectoris. 10660968

2000
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0003872
Disease: Arthritis, Psoriatic
Arthritis, Psoriatic 		0.310 Biomarker CTD_human Identification of NR4A2 as a transcriptional activator of IL-8 expression in human inflammatory arthritis. 19732956

2009
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C1258085
Disease: Barrett Epithelium
Barrett Epithelium 		0.310 Biomarker CTD_human This study was undertaken (1) to investigate the gene and protein expression of cyclooxygenase-2 (COX-2), peroxisome proliferator-activated receptor-gamma (PPARgamma), interleukin-8 (IL-8), hepatocyte growth factor (HGF), gastrin, and its receptor (CCK-2) in the Barrett's epithelium; (2) to analyze the activity of NFkappaB in Barrett's esophagus with low-grade dysplasia; and (3) to assess the effects of PPARgamma ligand (ciglitazone) and gastrin on cell proliferation in the cell line derived from esophageal adenocarcinoma (OE-33). 15387324

2004
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0004763
Disease: Barrett Esophagus
Barrett Esophagus 		0.340 Biomarker CTD_human Activation of NFkappaB represents the central event in the neoplastic progression associated with Barrett's esophagus: a possible link to the inflammation and overexpression of COX-2, PPARgamma and growth factors. 15387324

2004
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome 		0.400 Biomarker CTD_human Neutrophil adhesion to endothelial cells and factors affecting adhesion in patients with Behçet's disease. 8712863

1996
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.400 Biomarker CTD_human Interleukin-8 (IL-8) over-production and autocrine cell activation are key factors in monomethylarsonous acid [MMA(III)]-induced malignant transformation of urothelial cells. 22015448

2012
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.400 Biomarker CTD_human ERE-independent ERalpha target genes differentially expressed in human breast tumors. 16298037

2005
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.400 Biomarker CTD_human Serum cytokine levels of interleukin-1beta, -6, -8, tumour necrosis factor-alpha and vascular endothelial growth factor in breast cancer patients treated with tamoxifen and supplemented with co-enzyme Q(10), riboflavin and niacin. 17516992

2007
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C1704377
Disease: Bright Disease
Bright Disease 		0.300 Biomarker CTD_human Cytokines and T-cell responses in superantigen-related glomerulonephritis following methicillin-resistant Staphylococcus aureus infection. 10910440

2000
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C1704377
Disease: Bright Disease
Bright Disease 		0.300 Biomarker CTD_human A case of superantigen-related glomerulonephritis after methicillin-resistant Staphylococcus aureus (MRSA) infection. 9403216

1997
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0030805
Disease: Bullous pemphigoid
Bullous pemphigoid 		0.310 Biomarker CTD_human The IL-8 release from cultured human keratinocytes, mediated by antibodies to bullous pemphigoid autoantigen 180, is inhibited by dapsone. 11359455

2001
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0006625
Disease: Cachexia
Cachexia 		0.360 Biomarker CTD_human Molecular analysis of xenograft models of human cancer cachexia--possibilities for therapeutic intervention. 17878525

2007
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0205643
Disease: Carcinoma, Cribriform
Carcinoma, Cribriform 		0.300 Biomarker CTD_human Interleukin-8 increases vascular endothelial growth factor and neuropilin expression and stimulates ERK activation in human pancreatic cancer. 18307536

2008
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0205644
Disease: Carcinoma, Granular Cell
Carcinoma, Granular Cell 		0.300 Biomarker CTD_human Interleukin-8 increases vascular endothelial growth factor and neuropilin expression and stimulates ERK activation in human pancreatic cancer. 18307536

2008
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0876994
Disease: Cardiotoxicity
Cardiotoxicity 		0.300 Biomarker CTD_human TLR2 and TLR3 expression as a biomarker for the risk of doxorubicin-induced heart failure. 29959987

2018
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0008370
Disease: Cholestasis
Cholestasis 		0.300 Biomarker CTD_human Bile acids induce inflammatory genes in hepatocytes: a novel mechanism of inflammation during obstructive cholestasis. 21224055

2011