Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 842
Gene Symbol: CASP9
CASP9
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.500 Biomarker RGD LLI may protect the brain by upregulating Akt, pAkt, pBAD, and Bcl-2 expression and downregulating caspase 9 and caspase 3 expression following transient cerebral ischemia. 21712070

2011

Entrez Id: 842
Gene Symbol: CASP9
CASP9
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.500 Biomarker RGD Activation of cell death pathway after a brief period of global ischemia in diabetic and non-diabetic animals. 15246841

2004

Entrez Id: 3717
Gene Symbol: JAK2
JAK2
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.310 Biomarker RGD SMND-309, a novel derivative of salvianolic acid B, protects rat brains ischemia and reperfusion injury by targeting the JAK2/STAT3 pathway. 23764464

2013

Entrez Id: 94
Gene Symbol: ACVRL1
ACVRL1
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.300 Biomarker RGD TGF-{beta}1 activates two distinct type I receptors in neurons: implications for neuronal NF-{kappa}B signaling. 15781474

2005

Entrez Id: 4000
Gene Symbol: LMNA
LMNA
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.300 Biomarker RGD Proteomic characterization of protein phosphatase 1 complexes in ischemia-reperfusion and ischemic tolerance. 17683050

2007

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.240 Biomarker RGD Enriched environment reduces apolipoprotein E (ApoE) in reactive astrocytes and attenuates inflammation of the peri-infarct tissue after experimental stroke. 19623195

2009

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.220 Biomarker RGD Differential cellular expression of tumor necrosis factor-alpha and Type I tumor necrosis factor receptor after transient global forebrain ischemia. 11412877

2001

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.220 Biomarker RGD Peroxisome proliferator-activated receptorsgamma (PPARgamma) differently modulate the interleukin-6 expression in the peri-infarct cortical tissue in the acute and delayed phases of cerebral ischaemia. 18973594

2008

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.220 Biomarker RGD Comparison between single and combined treatment with candesartan and pioglitazone following transient focal ischemia in rat brain. 18378216

2008

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.220 Biomarker RGD Expression and activation of matrix metalloproteinase-2 and -9 in rat brain after transient focal cerebral ischemia. 11592852

2001

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.220 Biomarker RGD Ligand-activated peroxisome proliferator-activated receptor-gamma protects against ischemic cerebral infarction and neuronal apoptosis by 14-3-3 epsilon upregulation. 19221220

2009

Entrez Id: 5327
Gene Symbol: PLAT
PLAT
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.210 Biomarker RGD Role of tissue plasminogen activator/plasmin cascade in delayed neuronal death after transient forebrain ischemia. 15882815

2005

Entrez Id: 4502
Gene Symbol: MT2A
MT2A
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.210 Biomarker RGD Increased binding activity at an antioxidant-responsive element in the metallothionein-1 promoter and rapid induction of metallothionein-1 and -2 in response to cerebral ischemia and reperfusion. 10884303

2000

Entrez Id: 7132
Gene Symbol: TNFRSF1A
TNFRSF1A
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.210 Biomarker RGD Differential cellular expression of tumor necrosis factor-alpha and Type I tumor necrosis factor receptor after transient global forebrain ischemia. 11412877

2001

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.210 Biomarker RGD Post-insult ibuprofen treatment attenuates damage to the serotonergic system after hypoxia-ischemia in the immature rat brain. 23147509

2012

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.210 Biomarker RGD SMND-309, a novel derivative of salvianolic acid B, protects rat brains ischemia and reperfusion injury by targeting the JAK2/STAT3 pathway. 23764464

2013

Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.210 Biomarker RGD Temporal and spatial differences of multiple protein expression in the ischemic penumbra after transient MCAO in rats. 20417628

2010

Entrez Id: 27113
Gene Symbol: BBC3
BBC3
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.210 Biomarker RGD Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3-only protein Bbc3/PUMA and activation of the mitochondrial apoptosis pathway. 12913114

2003

Entrez Id: 286
Gene Symbol: ANK1
ANK1
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.210 Biomarker RGD Distribution of ankyrin isoforms and their proteolysis after ischemia and reperfusion in rat brain. 9202331

1997

Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.210 Biomarker RGD Ibuprofen protects ischemia-induced neuronal injury via up-regulating interleukin-1 receptor antagonist expression. 15837124

2005

Entrez Id: 8726
Gene Symbol: EED
EED
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.200 Biomarker RGD Early activation of nSMase2/ceramide pathway in astrocytes is involved in ischemia-associated neuronal damage via inflammation in rat hippocampi. 24007266

2013

Entrez Id: 4152
Gene Symbol: MBD1
MBD1
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.200 Biomarker RGD Transient forebrain ischemia alters the mRNA expression of methyl DNA-binding factors in the adult rat hippocampus. 12421618

2002

Entrez Id: 2332
Gene Symbol: FMR1
FMR1
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.200 Biomarker RGD Positive feedback regulation of Akt-FMRP pathway protects neurons from cell death. 22817682

2012

Entrez Id: 1627
Gene Symbol: DBN1
DBN1
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.200 Biomarker RGD Changes in drebrin, MAP2 (postsynaptic marker) and synaptophysin (presynaptic marker) in rat brains were examined after 20 min of transient cerebral ischemia. 8583659

1995

Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.200 Biomarker RGD Combination therapy of 17beta-estradiol and recombinant tissue plasminogen activator for experimental ischemic stroke. 19952306

2010