Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6416
Gene Symbol: MAP2K4
MAP2K4
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.200 Biomarker RGD A novel mechanism of JNK1 activation. Nuclear translocation and activation of JNK1 during ischemia and reperfusion. 9195981

1997

Entrez Id: 842
Gene Symbol: CASP9
CASP9
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.500 Biomarker RGD Activation of cell death pathway after a brief period of global ischemia in diabetic and non-diabetic animals. 15246841

2004

Entrez Id: 3776
Gene Symbol: KCNK2
KCNK2
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.200 Therapeutic RGD Activation of K(2)P channel-TREK1 mediates the neuroprotection induced by sevoflurane preconditioning. 24154701

2014

Entrez Id: 9510
Gene Symbol: ADAMTS1
ADAMTS1
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.200 Biomarker RGD ADAMTS-1 and -4 are up-regulated following transient middle cerebral artery occlusion in the rat and their expression is modulated by TNF in cultured astrocytes. 16630594

2006

Entrez Id: 9507
Gene Symbol: ADAMTS4
ADAMTS4
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.200 Biomarker RGD ADAMTS-1 and -4 are up-regulated following transient middle cerebral artery occlusion in the rat and their expression is modulated by TNF in cultured astrocytes. 16630594

2006

Entrez Id: 104
Gene Symbol: ADARB1
ADARB1
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.200 Biomarker RGD ADAR2-dependent RNA editing of AMPA receptor subunit GluR2 determines vulnerability of neurons in forebrain ischemia. 16504947

2006

Entrez Id: 1728
Gene Symbol: NQO1
NQO1
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.200 Therapeutic RGD Administration of 5-methoxyindole-2-carboxylic acid that potentially targets mitochondrial dihydrolipoamide dehydrogenase confers cerebral preconditioning against ischemic stroke injury. 29017857

2017

Entrez Id: 246213
Gene Symbol: SLC17A8
SLC17A8
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.200 Biomarker RGD Age and meloxicam modify the response of the glutamate vesicular transporters (VGLUTs) after transient global cerebral ischemia in the rat brain. 23458738

2013

Entrez Id: 57030
Gene Symbol: SLC17A7
SLC17A7
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.200 Biomarker RGD Age and meloxicam modify the response of the glutamate vesicular transporters (VGLUTs) after transient global cerebral ischemia in the rat brain. 23458738

2013

Entrez Id: 57084
Gene Symbol: SLC17A6
SLC17A6
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.200 Biomarker RGD Age and meloxicam modify the response of the glutamate vesicular transporters (VGLUTs) after transient global cerebral ischemia in the rat brain. 23458738

2013

Entrez Id: 6446
Gene Symbol: SGK1
SGK1
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.200 Biomarker RGD Alteration of serum/glucocorticoid regulated kinase-1 (sgk-1) gene expression in rat hippocampus after transient global ischemia. 15046873

2004

Entrez Id: 2936
Gene Symbol: GSR
GSR
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.200 Therapeutic RGD Amyloid Abeta1-40 preconditions non-apoptotic signals in vivo and protects fetal rat brain from intrauterine ischemic stress. 15525350

2004

Entrez Id: 3312
Gene Symbol: HSPA8
HSPA8
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.200 Biomarker RGD Assembly of proteins to postsynaptic densities after transient cerebral ischemia. 9425004

1998

Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.200 Therapeutic RGD Astrocytic P2Y(1) receptor is involved in the regulation of cytokine/chemokine transcription and cerebral damage in a rat model of cerebral ischemia. 21487414

2011

Entrez Id: 4052
Gene Symbol: LTBP1
LTBP1
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.200 Therapeutic RGD Beta(2)-adrenoceptor stimulation enhances latent transforming growth factor-beta-binding protein-1 and transforming growth factor-beta1 expression in rat hippocampus after transient forebrain ischemia. 11720783

2001

Entrez Id: 7351
Gene Symbol: UCP2
UCP2
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.200 Therapeutic RGD Both ischemic preconditioning and ghrelin administration protect hippocampus from ischemia/reperfusion and upregulate uncoupling protein-2. 19772611

2009

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.200 Therapeutic RGD Buyang Huanwu Decoction () reduces infarct volume and enhances estradiol and estradiol receptor concentration in ovariectomized rats after middle cerebral artery occlusion. 25098259

2014

Entrez Id: 1677
Gene Symbol: DFFB
DFFB
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.200 Biomarker RGD Caspase-activated DNase/DNA fragmentation factor 40 mediates apoptotic DNA fragmentation in transient cerebral ischemia and in neuronal cultures. 11425895

2001

Entrez Id: 857
Gene Symbol: CAV1
CAV1
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.200 Therapeutic RGD Caveolin-1 regulates nitric oxide-mediated matrix metalloproteinases activity and blood-brain barrier permeability in focal cerebral ischemia and reperfusion injury. 22007835

2012

Entrez Id: 1050
Gene Symbol: CEBPA
CEBPA
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.200 Biomarker RGD CCAAT-enhancer binding protein alpha is expressed in activated microglial cells after brain injury. 9795105

1998

Entrez Id: 1020
Gene Symbol: CDK5
CDK5
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.210 Therapeutic RGD Cdk5 is required for the neuroprotective effect of transforming growth factor-β1 against cerebral ischemia-reperfusion. 28254431

2017

Entrez Id: 815
Gene Symbol: CAMK2A
CAMK2A
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.200 Biomarker RGD Cerebral ischemia immediately increases serine phosphorylation of the synaptic RAS-GTPase activating protein SynGAP by calcium/calmodulin-dependent protein kinase II alpha in hippocampus of rats. 12951199

2003

Entrez Id: 50848
Gene Symbol: F11R
F11R
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.200 Therapeutic RGD Cerebralcare Granule® attenuates blood-brain barrier disruption after middle cerebral artery occlusion in rats. 22868201

2012

Entrez Id: 1627
Gene Symbol: DBN1
DBN1
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.200 Biomarker RGD Changes in drebrin, MAP2 (postsynaptic marker) and synaptophysin (presynaptic marker) in rat brains were examined after 20 min of transient cerebral ischemia. 8583659

1995

Entrez Id: 5111
Gene Symbol: PCNA
PCNA
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.200 Biomarker RGD Changes in proliferating cell nuclear antigen, a protein involved in DNA repair, in vulnerable hippocampal neurons following global cerebral ischemia. 9757027

1998