Source: CTD_human

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7048
Gene Symbol: TGFBR2
TGFBR2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.500 Biomarker CTD_human Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. 7761852

1995

Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.480 Biomarker CTD_human T-cell factor 4 functions as a tumor suppressor whose disruption modulates colon cell proliferation and tumorigenesis. 21383188

2011

Entrez Id: 8313
Gene Symbol: AXIN2
AXIN2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.470 Biomarker CTD_human Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer. 21188121

2009

Entrez Id: 1045
Gene Symbol: CDX2
CDX2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker CTD_human The Cdx2 homeobox gene suppresses intestinal tumorigenesis through non-cell-autonomous mechanisms. 29439001

2018

Entrez Id: 100507056
Gene Symbol: CCAT1
CCAT1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker CTD_human CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. 26752646

2016

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker CTD_human The concentrations of EGFR, LRG1, ITIH4, and F5 in serum correlate with the number of colonic adenomas in ApcPirc/+ rats. 25200834

2014

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker CTD_human Glucagon-like peptide-2 increases dysplasia in rodent models of colon cancer. 22323126

2012

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker CTD_human Rapid induction of colon carcinogenesis in CYP1A-humanized mice by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate. 21081470

2011

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker CTD_human Rapid induction of colon carcinogenesis in CYP1A-humanized mice by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate. 21081470

2011

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker CTD_human Rapid induction of colon carcinogenesis in CYP1A-humanized mice by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate. 21081470

2011

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker CTD_human Rapid induction of colon carcinogenesis in CYP1A-humanized mice by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate. 21081470

2011

Entrez Id: 1026
Gene Symbol: CDKN1A
CDKN1A
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker CTD_human Inhibition of autophagy enhances anticancer effects of atorvastatin in digestive malignancies. 20876807

2010

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker CTD_human Polymorphisms in interleukin 1 beta and interleukin 1 receptor antagonist associated with tumor recurrence in stage II colon cancer. 18987561

2009

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker CTD_human Melatonin suppresses AOM/DSS-induced large bowel oncogenesis in rats. 19028472

2009

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker CTD_human gamma-Secretase inhibitors abrogate oxaliplatin-induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity. 19147571

2009

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker CTD_human Melatonin suppresses AOM/DSS-induced large bowel oncogenesis in rats. 19028472

2009

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Therapeutic CTD_human Melatonin suppresses AOM/DSS-induced large bowel oncogenesis in rats. 19028472

2009

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker CTD_human Melatonin suppresses AOM/DSS-induced large bowel oncogenesis in rats. 19028472

2009

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker CTD_human Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer. 21188121

2009

Entrez Id: 8549
Gene Symbol: LGR5
LGR5
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker CTD_human Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer. 21188121

2009

Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker CTD_human Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer. 21188121

2009

Entrez Id: 1786
Gene Symbol: DNMT1
DNMT1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker CTD_human 5-Azacytidine prevents cisplatin induced nephrotoxicity and potentiates anticancer activity of cisplatin by involving inhibition of metallothionein, pAKT and DNMT1 expression in chemical induced cancer rats. 19723570

2009

Entrez Id: 51176
Gene Symbol: LEF1
LEF1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker CTD_human Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer. 21188121

2009

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker CTD_human Protective versus promotional effects of white tea and caffeine on PhIP-induced tumorigenesis and beta-catenin expression in the rat. 18283038

2008

Entrez Id: 7298
Gene Symbol: TYMS
TYMS
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker CTD_human Thymidylate synthase, dihydropyrimidine dehydrogenase, ERCC1, and thymidine phosphorylase gene expression in primary and metastatic gastrointestinal adenocarcinoma tissue in patients treated on a phase I trial of oxaliplatin and capecitabine. 19105824

2008