|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
HLA-DRB1 alleles showed no strong association with UC, and no HLA-DRB1 alleles or genotypes were strongly associated with clinical subgroups of UC in Chinese patients.
|
16426241 |
2006 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
In the association study the rare DRB1*103 (8.3% vs 3.2% in controls) and DRB1*12 (8.6% vs 2.1% in controls) alleles were associated with ulcerative colitis (p = 0.0074, chi2 = 7.22, odds ratio OR = 2.9 [95% CI 1.3-6.4] and p = 0.0056, chi2 = 12.63, OR = 4.33 [1.8-11.0] respectively).
|
8622450 |
1996 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
This appears to be true for both inflammatory bowel diseases as HLA-DRB1*0103 is associated both with colonic Crohn's disease and ulcerative colitis.
|
15626888 |
2004 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
The most implicated gene is HLA-DRB1, with HLA-DRB1*03:01 the most associated risk allele in both Crohn's disease and ulcerative colitis.
|
31518029 |
2019 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
Significant increase was observed in Bw52, DPw9 (DPB1*0901), and DR2 (DRB1*1502) in Japanese patients with UC.
|
8096500 |
1993 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
This is the novel result that describes an association of HLA-DRB1*13 with UC and also shows the protective role of HLA-DRB1*04 against the disease in people of Kerman.
|
26546900 |
2015 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
Integrative analysis of TWAS and messenger RNA (mRNA) expression data detected several tissues related common genes for UC, such as HLA-DRB1 (P<sub>TWAS</sub> = 0.024; mRNA expression ratio = 1.700) and TAP2 in colon (P <sub>TWAS</sub> = 0.047; mRNA expression ratio = 2.170).
|
31009124 |
2019 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
Our data are consistent with those of Japanese studies in that DR2 and DRB1*1502 are positively associated with UC patients.
|
12073071 |
2002 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
Our previously reported association of DR2 with UC was attributable to DRB1*1502 (OR = 2.6, p = 0.006).
|
10689124 |
2000 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
As a whole, after applying Bonferroni's correction for multiple comparisons, no significant association of HLA-DRB1 alleles with Crohn's disease or ulcerative colitis was found.
|
15690658 |
2005 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
Recent studies have suggested that HLA DRB1*0103 and allele 2 of the interleukin 1 receptor antagonist (IL-1RA) gene predict severe and extensive ulcerative colitis, respectively.
|
9178675 |
1997 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
Patients with ulcerative colitis (n = 107) and 200 controls were typed using molecular, DNA-based techniques for HLA-DRB1, DQA1 and DQB1 alleles.
|
9182881 |
1997 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
Haplotype-based analysis in the major histocompatibility complex region showed that HLA-Cw*1202-B*5201-DRB1*1502 haplotype was significantly associated with increased risk of UC compared with CD (P = 1.1 × 10⁻³³; OR = 6.58), accounting for most of the associations observed in the GWAS.
|
21699788 |
2011 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
Previously, we have reported that the DRB1*1502 and DRw11 genes were closely related to the intractability of UC.
|
11993515 |
2002 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
We confirmed that the NKX2-3 polymorphism is associated with common susceptibility to IBD and that HLA-DRB1*0450 alleles increase susceptibility to CD but reduce risk for UC while HLA-DRB1*1502 alleles increase susceptibility to UC but reduce CD risk.
|
23942620 |
2014 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
Genetic polymorphisms of the HLA-DRB1*08 and *13 may contribute to the clinical heterogeneity of UC between Uyghur and Han UC patients in China.
|
24597629 |
2014 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
In addition, 9 genes previously associated with IBD contained SNPs with significant evidence for replication (P < 1.6 × 10<sup>-6</sup>): ADCY3, CXCR6, HLA-DRB1 to HLA-DQA1 (genome-wide significance on conditioning), IL12B,PTGER4, and TNC for IBD; IL23R, PTGER4, and SNX20 (in strong linkage disequilibrium with NOD2) for CD; and KCNQ2 (near TNFRSF6B) for UC.
|
27693347 |
2017 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
This study provides additional evidence for the role of DRB1 alleles in the susceptibility to UC, and supports the hypothesis that these alleles may determine the severity of the disease.
|
9933456 |
1999 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
The allelic combination DRB1*0103/D6S273-5/BAT_2-8/TNFa11b4c1d3e3/IKBL+738(C)/MICA5.1 that includes the telomeric class III markers of the 7.1 ancestral haplotype is highly increased in patients with UC (P=0.0001, OR=10.57), especially in those with the extensive form of the disease (P=0.02, OR=3.41 extensive versus distal).
|
16116311 |
2005 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
To address this, we performed high-density SNP typing of the MHC in >32,000 individuals with IBD, implicating multiple HLA alleles, with a primary role for HLA-DRB1*01:03 in both Crohn's disease and ulcerative colitis.
|
25559196 |
2015 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
Whereas the association with the HLA-DRB1*15 allele has been described in several independent studies for ulcerative colitis, no contribution of HLA alleles to susceptibility in Crohn's disease has yet been shown.
|
8707084 |
1996 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
DR2, DR9, and DRB1*0103 were positively associated with ulcerative colitis, and a negative association was found for DR4 and ulcerative colitis.
|
10446108 |
1999 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
The HLA-DRB1*1502 allele was significantly more frequent in the Indian UC cohort (29.2%) than controls (17.6%) (P = 0.04) and the allele was absent in the white European cohort.
|
24145928 |
2013 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
Biomarker |
BEFREE |
In a case-control approach, HLA-DRB1*15:02 was associated with UC in never smokers (OR<sub>never smokers</sub> = 3.20, P<sub>never smokers</sub> = 7.88 × 10<sup>-23</sup> ) but not in current or former smokers (P<sub>current smokers</sub> = 0.72 and P<sub>former smokers</sub> = 0.33, respectively).
|
31038770 |
2019 |
|
HLA-DRB1
|
Ulcerative Colitis
|
0.500 |
GeneticVariation |
BEFREE |
We conclude that BTNL2 does not contribute to the susceptibility to Japanese CD but is associated with Japanese UC because of the strong LD with HLA-DRB1*1502.
|
17610417 |
2007 |