Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.350 Therapeutic CTD_human Lipopolysaccharide and trovafloxacin coexposure in mice causes idiosyncrasy-like liver injury dependent on tumor necrosis factor-alpha. 17709330

2007
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.350 Biomarker CTD_human Tumor necrosis factor genomic polymorphism and outcome of acetaminophen (paracetamol)-induced acute liver failure. 9696492

1998
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.350 Therapeutic CTD_human Tumor necrosis factor genomic polymorphism and outcome of acetaminophen (paracetamol)-induced acute liver failure. 9696492

1998
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.350 Biomarker CTD_human Antioxidative roles of metallothionein and manganese superoxide dismutase induced by tumor necrosis factor-alpha and interleukin-6. 7532385

1995
Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.350 Therapeutic CTD_human Antioxidative roles of metallothionein and manganese superoxide dismutase induced by tumor necrosis factor-alpha and interleukin-6. 7532385

1995
Entrez Id: 3105
Gene Symbol: HLA-A
HLA-A
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.330 Biomarker CTD_human In a GWAS of persons of European descent with DILI, we associated HLA-A*33:01 with DILI due to terbinafine and possibly fenofibrate and ticlopidine. 28043905

2017
Entrez Id: 3565
Gene Symbol: IL4
IL4
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.330 Therapeutic CTD_human Endogenous interleukin-4 regulates glutathione synthesis following acetaminophen-induced liver injury in mice. 22107450

2012
Entrez Id: 3565
Gene Symbol: IL4
IL4
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.330 Biomarker CTD_human Endogenous interleukin-4 regulates glutathione synthesis following acetaminophen-induced liver injury in mice. 22107450

2012
Entrez Id: 3565
Gene Symbol: IL4
IL4
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.330 Therapeutic CTD_human Involvement of Th2 cytokines in the mouse model of flutamide-induced acute liver injury. 21735453

2012
Entrez Id: 3565
Gene Symbol: IL4
IL4
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.330 Biomarker CTD_human Involvement of Th2 cytokines in the mouse model of flutamide-induced acute liver injury. 21735453

2012
Entrez Id: 213
Gene Symbol: ALB
ALB
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.330 Biomarker CTD_human Mangiferin exerts hepatoprotective activity against D-galactosamine induced acute toxicity and oxidative/nitrosative stress via Nrf2-NFκB pathways. 22310181

2012
Entrez Id: 3565
Gene Symbol: IL4
IL4
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.330 Biomarker CTD_human IL-4 mediates dicloxacillin-induced liver injury in mice. 21094227

2011
Entrez Id: 3105
Gene Symbol: HLA-A
HLA-A
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.330 Biomarker CTD_human Susceptibility to amoxicillin-clavulanate-induced liver injury is influenced by multiple HLA class I and II alleles. 21570397

2011
Entrez Id: 3565
Gene Symbol: IL4
IL4
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.330 Therapeutic CTD_human IL-4 mediates dicloxacillin-induced liver injury in mice. 21094227

2011
Entrez Id: 213
Gene Symbol: ALB
ALB
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.330 Biomarker CTD_human Detection of cell-free, liver-specific mRNAs in peripheral blood from rats with hepatotoxicity: a potential toxicological biomarker for safety evaluation. 18779383

2008
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.330 Therapeutic CTD_human Interleukin-6 protects hepatocytes from CCl4-mediated necrosis and apoptosis in mice by reducing MMP-2 expression. 15763341

2005
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.330 Therapeutic CTD_human Antioxidative roles of metallothionein and manganese superoxide dismutase induced by tumor necrosis factor-alpha and interleukin-6. 7532385

1995
Entrez Id: 1557
Gene Symbol: CYP2C19
CYP2C19
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.320 Biomarker CTD_human Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury. 28762043

2018
Entrez Id: 1559
Gene Symbol: CYP2C9
CYP2C9
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.320 Biomarker CTD_human Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury. 28762043

2018
Entrez Id: 9970
Gene Symbol: NR1I3
NR1I3
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.320 Biomarker CTD_human Hepatotoxic effects of cyproconazole and prochloraz in wild-type and hCAR/hPXR mice. 28058446

2017
Entrez Id: 9970
Gene Symbol: NR1I3
NR1I3
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.320 Therapeutic CTD_human Hepatotoxic effects of cyproconazole and prochloraz in wild-type and hCAR/hPXR mice. 28058446

2017
Entrez Id: 9970
Gene Symbol: NR1I3
NR1I3
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.320 Therapeutic CTD_human Involvement of constitutive androstane receptor in liver hypertrophy and liver tumor development induced by triazole fungicides. 25656644

2015
Entrez Id: 9970
Gene Symbol: NR1I3
NR1I3
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.320 Biomarker CTD_human Involvement of constitutive androstane receptor in liver hypertrophy and liver tumor development induced by triazole fungicides. 25656644

2015
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.320 Biomarker CTD_human Characterization of chemically induced liver injuries using gene co-expression modules. 25226513

2014
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.320 Biomarker CTD_human Phenotypic and genotypic assessment of concomitant drug-induced toxic effects in liver, kidney and blood. 20623750

2011