Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4803
Gene Symbol: NGF
NGF
CUI: C0020075
Disease: Hereditary Sensory Autonomic Neuropathy, Type 5
Hereditary Sensory Autonomic Neuropathy, Type 5 		0.800 GeneticVariation UNIPROT Frequency of mutations in the genes associated with hereditary sensory and autonomic neuropathy in a UK cohort. 22302274

2012
Entrez Id: 4803
Gene Symbol: NGF
NGF
CUI: C0020075
Disease: Hereditary Sensory Autonomic Neuropathy, Type 5
Hereditary Sensory Autonomic Neuropathy, Type 5 		0.800 GeneticVariation UNIPROT It is concluded that the HSAN4 and HSAN5 phenotypes are parts of a phenotypic spectrum caused by changes in the NGF/TRKA signalling pathway. 20978020

2011
Entrez Id: 4803
Gene Symbol: NGF
NGF
CUI: C0020075
Disease: Hereditary Sensory Autonomic Neuropathy, Type 5
Hereditary Sensory Autonomic Neuropathy, Type 5 		0.800 Biomarker GENOMICS_ENGLAND Nerve growth factor R221W responsible for insensitivity to pain is defectively processed and accumulates as proNGF. 19038341

2009
Entrez Id: 4803
Gene Symbol: NGF
NGF
CUI: C0020075
Disease: Hereditary Sensory Autonomic Neuropathy, Type 5
Hereditary Sensory Autonomic Neuropathy, Type 5 		0.800 Biomarker GENOMICS_ENGLAND A mutation in the nerve growth factor beta gene (NGFB) causes loss of pain perception. 14976160

2004
Entrez Id: 4803
Gene Symbol: NGF
NGF
CUI: C0020075
Disease: Hereditary Sensory Autonomic Neuropathy, Type 5
Hereditary Sensory Autonomic Neuropathy, Type 5 		0.800 Biomarker GENOMICS_ENGLAND A mutation in the nerve growth factor beta gene (NGFB) causes loss of pain perception. 14976160

2004
Entrez Id: 4803
Gene Symbol: NGF
NGF
CUI: C0020075
Disease: Hereditary Sensory Autonomic Neuropathy, Type 5
Hereditary Sensory Autonomic Neuropathy, Type 5 		0.800 Biomarker GENOMICS_ENGLAND Structure of nerve growth factor complexed with the shared neurotrophin receptor p75. 15131306

2004
Entrez Id: 4803
Gene Symbol: NGF
NGF
CUI: C0020075
Disease: Hereditary Sensory Autonomic Neuropathy, Type 5
Hereditary Sensory Autonomic Neuropathy, Type 5 		0.800 GermlineCausalMutation ORPHANET A mutation in the nerve growth factor beta gene (NGFB) causes loss of pain perception. 14976160

2004
Entrez Id: 4803
Gene Symbol: NGF
NGF
CUI: C0020075
Disease: Hereditary Sensory Autonomic Neuropathy, Type 5
Hereditary Sensory Autonomic Neuropathy, Type 5 		0.800 GeneticVariation UNIPROT A mutation in the nerve growth factor beta gene (NGFB) causes loss of pain perception. 14976160

2004
Entrez Id: 4803
Gene Symbol: NGF
NGF
CUI: C0020075
Disease: Hereditary Sensory Autonomic Neuropathy, Type 5
Hereditary Sensory Autonomic Neuropathy, Type 5 		0.800 Biomarker GENOMICS_ENGLAND Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system. 1317267

1992
Entrez Id: 4803
Gene Symbol: NGF
NGF
CUI: C0020075
Disease: Hereditary Sensory Autonomic Neuropathy, Type 5
Hereditary Sensory Autonomic Neuropathy, Type 5 		0.800 Biomarker CTD_human

Entrez Id: 4803
Gene Symbol: NGF
NGF
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.600 Biomarker CTD_human To confirm that the remaining, TrkA(+)/IB4(-), nociceptors are still functional, we evaluated if nerve growth factor (NGF) induced hyperalgesia. 20457222

2010
Entrez Id: 4803
Gene Symbol: NGF
NGF
CUI: C0878773
Disease: Overactive Bladder
Overactive Bladder 		0.590 Biomarker CTD_human Nerve growth factor and prostaglandins in the urine of female patients with overactive bladder. 16600756

2006
Entrez Id: 4803
Gene Symbol: NGF
NGF
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.580 Biomarker PSYGENET These data are consistent with our previous findings linking NGF and APP signaling and suggest a causal relationship between altered synaptic connectivity, cholinergic tone depression and TrkA signaling deficit, and cognitive and neuromuscular decline in APP(YG/YG) mice. 23020178

2012
Entrez Id: 4803
Gene Symbol: NGF
NGF
CUI: C0010692
Disease: Cystitis
Cystitis 		0.560 Biomarker CTD_human Overexpression of NGF is known to mediate inflammation of bladder in this model. 16889433

2006
Entrez Id: 4803
Gene Symbol: NGF
NGF
CUI: C0021368
Disease: Inflammation
Inflammation 		0.510 Biomarker CTD_human Inhibition of carrageenan-induced edema by indomethacin or sodium salicylate does not prevent the increase of nerve growth factor in the rat hind paw. 10653021

2000
Entrez Id: 4803
Gene Symbol: NGF
NGF
CUI: C0524851
Disease: Neurodegenerative Disorders
Neurodegenerative Disorders 		0.400 Therapeutic CTD_human Considering that nerve growth factor exerts beneficial effects in the treatment of major central and peripheral neurodegenerative diseases, skin and corneal ulcers, we asked whether nerve growth factor could also exert a role in Cyclosporine A-induced graft nephrotoxicity. 24244623

2013
Entrez Id: 4803
Gene Symbol: NGF
NGF
CUI: C0020074
Disease: HSAN Type IV
HSAN Type IV 		0.400 Biomarker CTD_human

Entrez Id: 4803
Gene Symbol: NGF
NGF
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia 		0.390 Biomarker CTD_human Hyperalgesic priming is restricted to isolectin B4-positive nociceptors. 20457222

2010
Entrez Id: 4803
Gene Symbol: NGF
NGF
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.380 Biomarker PSYGENET These data are consistent with our previous findings linking NGF and APP signaling and suggest a causal relationship between altered synaptic connectivity, cholinergic tone depression and TrkA signaling deficit, and cognitive and neuromuscular decline in APP(YG/YG) mice. 23020178

2012
Entrez Id: 4803
Gene Symbol: NGF
NGF
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.360 Biomarker CTD_human IGF-I and IGF-II resistance was present in DLB but not PD frontal cortex, and associated with reduced expression of Hu, nerve growth factor, and Trk neurotrophin receptors, and increased levels of glial fibrillary acidic protein, alpha-synuclein, dopamine-beta-hydroxylase, 4-hydroxy-2-nonenal (HNE), and ubiquitin immunoreactivity. 19276553

2009
Entrez Id: 4803
Gene Symbol: NGF
NGF
CUI: C0036572
Disease: Seizures
Seizures 		0.350 Biomarker CTD_human Overall, these studies demonstrate the requirement for NRIF to signal p75(NTR)-mediated apoptosis of hippocampal neurons and that blocking pro-NGF can inhibit neuronal loss after seizures. 18815271

2008
Entrez Id: 4803
Gene Symbol: NGF
NGF
CUI: C0027765
Disease: nervous system disorder
nervous system disorder 		0.350 Therapeutic CTD_human Nerve growth factor protects R2 cells against neurotoxicity induced by methamphetamine. 15093677

2004
Entrez Id: 4803
Gene Symbol: NGF
NGF
CUI: C4721453
Disease: Peripheral Nervous System Diseases
Peripheral Nervous System Diseases 		0.340 Biomarker CTD_human Early predictors of peripheral neurotoxicity in cisplatin and paclitaxel combination chemotherapy. 15319252

2004
Entrez Id: 4803
Gene Symbol: NGF
NGF
CUI: C0740391
Disease: Middle Cerebral Artery Occlusion
Middle Cerebral Artery Occlusion 		0.340 Therapeutic CTD_human Reduction of ischemic damage in NGF-transgenic mice: correlation with enhancement of antioxidant enzyme activities. 10408807

1999
Entrez Id: 4803
Gene Symbol: NGF
NGF
CUI: C0027889
Disease: Hereditary Sensory and Autonomic Neuropathies
Hereditary Sensory and Autonomic Neuropathies 		0.330 Biomarker CTD_human