|
rs9939609
|
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate the association of candidate gene single nucleotide polymorphisms (SNPs), namely FTO (rs9939609) and VDR (rs1544410), with obesity in the UAE population.
|
29343214 |
2018 |
|
rs9939609
|
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
The rs9939609 polymorphism of FTO gene is associated with obesity, especially obesity class III in women.
|
30041557 |
2018 |
|
rs9939609
|
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
This finding was evident only in nonobese subjects.The FTO rs9939609 polymorphism is an independent risk factor for obesity and also for biological aging in the nonobese population.
|
28746203 |
2017 |
|
rs9939609
|
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
Association between overweight and obesity in schoolchildren with rs9939609 polymorphism (FTO) and family history for obesity.
|
27154418 |
2017 |
|
rs9939609
|
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
Recently, we reported that having depression moderates the effect of the <i>FTO</i> gene, suggesting its implication in the association between depression and obesity.<b>Aims</b>To confirm these findings by investigating the <i>FTO</i> polymorphism rs9939609 in new cohorts, and subsequently in a meta-analysis.<b>Method</b>The sample consists of 6902 individuals with depression and 6799 controls from three replication cohorts and two original discovery cohorts.
|
28642257 |
2017 |
|
rs9939609
|
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
To further elucidate the role of genetics in obesity onset, we performed a candidate-gene association study in a young and sportive Italian population by testing the association of functional polymorphisms in ACE (rs4646994), FTO (rs9939609), MC4R (rs17782313) and PPARG (rs1801282) genes with body mass index (BMI) and waist-to-height ratio (WHtR).
|
28090739 |
2017 |
|
rs9939609
|
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
In this multi-analytical approach, FTO rs9939609 and IRX3 rs3751723, along with TCF7L2 rs7903146 and TMEM18 rs6548238, emerged as the major SNPs contributing to BMI linked obesity risk in the North Indian population.
|
27650258 |
2017 |
|
rs9939609
|
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
Using a well-known obesity risk polymorphism (FTO rs9939609) in a sample of 78 children (ages 9-12 y), we observed that children at risk for obesity exhibited stronger responses to food commercials in the nucleus accumbens (NAcc) than children not at risk.
|
27994159 |
2017 |
|
rs9939609
|
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
The aim of this study was to explore whether interactions between FTO rs9939609 and ABCA1 rs9282541 affect BMI and waist circumference (WC), and could explain previously reported population differences in FTO-obesity and FTO-BMI associations in the Mexican and European populations.
|
28464932 |
2017 |
|
rs9939609
|
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
FTO rs9939609 is associated with obesity risk and LTL in this study, where this association is only observed at higher, but not lower, FTO methylation levels of participants.
|
28559540 |
2017 |
|
rs9939609
|
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
Variants (rs1558902, rs1121980, rs9939609, and rs9941349) in the fat mass and obesity-associated (FTO) gene exhibited strong but ethnicity-independent association with obesity.
|
28988247 |
2017 |
|
rs9939609
|
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
This study reveals interactions between rs9939609 and PA on obesity indices in Portuguese young adults, suggesting a change in the different body components (lean and fat mass) depending on the FTO genotypes.
|
25809737 |
2016 |
|
rs9939609
|
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
To investigate the association between the fat mass and obesity related (FTO) gene rs9939609 and near melanocortin-4-receptor (MC4R) gene rs17782313 polymorphisms with obesity measures and metabolic parameters in urban and rural dwelling Sri Lankans.
|
26948330 |
2016 |
|
rs9939609
|
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
This study demonstrated that the rs9939609 (FTO) polymorphism showed a relationship with obesity in the population studied and an interaction with CRF.
|
26458076 |
2016 |
|
rs9939609
|
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
The aim of the current study was to analyze the effect of six type II diabetes GWAS loci rs3923113 (GRB14), rs16861329 (ST6GAL1), rs1802295 (VPS26A), rs7178572 (HMG20A), rs2028299 (AP3S2) and rs4812829 (HNF4A), and an FTO polymorphism (rs9939609) on obesity.
|
26395551 |
2016 |
|
rs9939609
|
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
Two SNP genotypes related to obesity were more prevalent in women with abnormal triglyceride levels and two vascular and inflammatory serum markers were higher in relation to the rs9939609 SNP.
|
26902996 |
2016 |
|
rs9939609
|
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
The maternal and infant AA genotype of the obesity associated FTO rs9939609 SNP associates with increased risk for SGA and sPTB.
|
27768255 |
2016 |
|
rs9939609
|
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
Here, we explore the brain structural substrate of the obesity-predisposing rs9939609 T/A variant of the FTO gene in non-obese subjects by means of multivariate classification and use fMRI to investigate genotype-specific differences in neural food-cue reactivity by analysing correlates of a visual food perception task.
|
26767945 |
2016 |
|
rs9939609
|
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
The rs9939609 fat mass and obesity-associated gene (FTO) polymorphism has been implicated in the susceptibility of obesity.
|
25801113 |
2016 |
|
rs9939609
|
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
Physical activity, but not dietary intake, attenuates the effect of the FTO rs9939609 polymorphism on obesity and metabolic syndrome in Lithuanian adult population.
|
27003669 |
2016 |
|
rs9939609
|
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
The aim of this study was to assess the impact of mothers' and newborns' fat mass and obesity-associated gene (FTO) rs9939609 and leptin receptor (LEPR) rs1137101 gene polymorphisms on neonatal anthropometric parameters in order to identify a potential risk for developing obesity.We performed a cross-sectional study on 355 mother-newborn couples in an Obstetrics Gynecology Tertiary Hospital from Romania, evaluated with regard to anthropometric parameters, clinical and laboratory parameters besides 2 genetic polymorphisms (FTO rs9939609 and LEPR rs1137101).Newborns with mothers carrying variant AT or AA genotype for FTO rs9939609 presented lower BMI (P = 0.012) and lower MUAC (P = 0.029).
|
27930556 |
2016 |
|
rs9939609
|
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
When T2D cohort was further stratified according to the obesity status, PPARγ2 (rs1801282) and FTO (rs9939609) showed association with T2D only in the obese diabetic group and ADIPOQ (rs16861194) showed no difference in risk of susceptibility to the disease.
|
26243686 |
2016 |
|
rs9939609
|
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
In single locus analysis, FTO rs8050136 CA (p = 0.0001; OR (95% CI) = 2.4 (1.7-3.4) and AA (p = 0.0001; OR (95% CI) = 3.1 (1.9-5.2); FTO rs1421085 TA (p = 0.0001; OR (95% CI) = 2.1 (1.4-3.0) and AA (p = 0.0001; OR (95% CI) = 3.0 (1.8-5.0); FTO rs9939609 TC (p = 0.0001; OR (95% CI) = 2.1 (1.5-3.1) and CC (p = 0.0001; OR (95% CI) = 4.2 (2.5-7.3) along with TG (p = 0.001; OR (95% CI) = 2.1 (1.3-3.2) and GG (p = 0.021; OR (95% CI) = 3.8 (1.2-11.8) genotypes of FTO rs17817449 with GT (p = 0.0001; OR (95% CI) = 2.1 (1.5-3.1) and TT (p = 0.012; OR (95% CI) = 3.3 (1.8-3.6) genotypes of IRX3 rs3751723 were significantly associated with obesity.
|
26440677 |
2016 |
|
rs9939609
|
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
The single nucleotide polymorphism rs9939609 of the gene FTO, which encodes fat mass and obesity-associated protein, is strongly associated with obesity and type 2 diabetes (T2D) in multiple populations; however, the underlying mechanism of this association is unclear.
|
27249024 |
2016 |
|
rs9939609
|
|
Obesity
|
|
0.800 |
GeneticVariation
|
BEFREE |
Risk allele carriers of rs17817449 SNP had somewhat higher values of weight, body mass index, waist and hip circumference, total cholesterol, triglycerides, adiponectin, and fasting glucose.This study revealed the genetic association between rs9939609 SNP of FTO and obesity in a Romanian population, and to the authors' knowledge, this is the first study to investigate this association in a Romanian population.
|
27196486 |
2016 |