|
rs2162679
|
|
Malignant neoplasm of pancreas
|
|
0.010 |
GeneticVariation
|
BEFREE |
No significant relationship was found between rs2195239 and breast or pancreatic cancer risk. rs2162679 reduces the overall cancer risk in allele, homozygote, dominant, and recessive models, as well as reducing cancer risk in Asian populations in allele, homozygote, and recessive models.
|
30654740 |
2019 |
|
rs2162679
|
|
Pancreatic carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
No significant relationship was found between rs2195239 and breast or pancreatic cancer risk. rs2162679 reduces the overall cancer risk in allele, homozygote, dominant, and recessive models, as well as reducing cancer risk in Asian populations in allele, homozygote, and recessive models.
|
30654740 |
2019 |
|
rs2162679
|
|
Myocardial Infarction
|
|
0.010 |
GeneticVariation
|
BEFREE |
The frequency of the A-T-G-T haplotype for rs2162679-rs7956547-rs978458-rs6218 was also significantly higher in the MI group (47.3%) as compared to the non-MI group (41.3%) (p=0.033, odds ratio=1.276).
|
21039458 |
2010 |
|
rs2162679
|
|
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
IGF1 rs2195239 and rs2162679 were associated with overall cancer risk based on present studies.
|
30654740 |
2019 |
|
rs2162679
|
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
IGF1 rs2195239 and rs2162679 were associated with overall cancer risk based on present studies.
|
30654740 |
2019 |
|
rs12423791
|
|
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
When the sum of the risk genetic factors in each LD block (19-repeat allele, C allele of rs12423791, or C-T haplotype) was considered, patients with all the risk factors had significantly shorter cancer specific-survival than those with 0-2 risk factors (P = 0.0003).
|
23530598 |
2013 |
|
rs12423791
|
|
Myopia
|
|
0.010 |
GeneticVariation
|
BEFREE |
The polymorphism of rs12423791 in IGF-1 may be associated with extreme myopia in the Chinese population and should be investigated further.
|
22509095 |
2012 |
|
rs12423791
|
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
When the sum of the risk genetic factors in each LD block (19-repeat allele, C allele of rs12423791, or C-T haplotype) was considered, patients with all the risk factors had significantly shorter cancer specific-survival than those with 0-2 risk factors (P = 0.0003).
|
23530598 |
2013 |
|
rs12423791
|
|
Severe myopia
|
|
0.010 |
GeneticVariation
|
BEFREE |
This meta-analysis shows that IGF-1 rs12423791 or rs6214 gene polymorphism is not associated with high myopia.
|
26076017 |
2015 |
|
rs12423791
|
|
Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
SNPs of the IGF1R (rs12423791), and IGF1 (rs2162679, rs5742612, rs35767) genes were significantly associated with tumor response to FOLFOX.
|
27144430 |
2016 |
|
rs1239905891
|
|
Mammary Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
The purposes of this study were to analyse the genotype of TGF-beta1 at T29C and TGF-beta1 phenotype in breast tumours, and to evaluate their associations with IGFs and clinical characteristics of breast cancer.
|
18827819 |
2008 |
|
rs1239905891
|
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation
|
BEFREE |
The purposes of this study were to analyse the genotype of TGF-beta1 at T29C and TGF-beta1 phenotype in breast tumours, and to evaluate their associations with IGFs and clinical characteristics of breast cancer.
|
18827819 |
2008 |
|
rs1239905891
|
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The purposes of this study were to analyse the genotype of TGF-beta1 at T29C and TGF-beta1 phenotype in breast tumours, and to evaluate their associations with IGFs and clinical characteristics of breast cancer.
|
18827819 |
2008 |
|
rs6214
|
|
Severe myopia
|
|
0.040 |
GeneticVariation
|
BEFREE |
This meta-analysis shows that IGF-1 rs12423791 or rs6214 gene polymorphism is not associated with high myopia.
|
26076017 |
2015 |
|
rs6214
|
|
Severe myopia
|
|
0.040 |
GeneticVariation
|
BEFREE |
To determine the distribution of the HM-associated SNPs rs6214 and rs10860860, 543 unrelated individuals from the general Polish population were also analyzed.
|
21976954 |
2011 |
|
rs6214
|
|
Severe myopia
|
|
0.040 |
GeneticVariation
|
BEFREE |
This meta-analysis showed there was no association detected between IGF1 rs6214 and high myopia.
|
28135889 |
2017 |
|
rs6214
|
|
Severe myopia
|
|
0.040 |
GeneticVariation
|
BEFREE |
We found a significant association of the IGF-1 gene rs6214 polymorphism in Egyptian patients with simple myopia and high-grade myopia.
|
27167306 |
2016 |
|
rs6220
|
|
Breast Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
In the current study, IGF-1 gene polymorphism of SNP variants rs6220 and rs7136446 had no statistically significant association with breast cancer, both in premenopausal and postmenopausal women.
|
28315227 |
2017 |
|
rs6220
|
|
Malignant neoplasm of breast
|
|
0.030 |
GeneticVariation
|
BEFREE |
In the current study, IGF-1 gene polymorphism of SNP variants rs6220 and rs7136446 had no statistically significant association with breast cancer, both in premenopausal and postmenopausal women.
|
28315227 |
2017 |
|
rs6220
|
|
Breast Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Also, rs6220 was associated with a significantly increased risk of breast cancer under the homozygote model (GG vs AA: OR, 1.23, 95% CI, 1.02-1.48, P = .031).
|
30572549 |
2018 |
|
rs6220
|
|
Breast Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
We aimed to study the nine htSNPs in three haplotype blocks (block1: rs855211, rs35765, rs2162679; block2: rs1019731, rs7956547, rs5742632; and block3 rs2033178, rs7136446, rs6220) combined into diplotypes, and three additional SNPs (rs5742612, rs35765817, rs35455143) in relation to IGF-1 levels, BRCA status, the IGF1 CA-repeat microsatellite, and breast cancer in a population of 325 Swedish women from breast cancer high-risk families.
|
21113804 |
2011 |
|
rs6220
|
|
Malignant neoplasm of breast
|
|
0.030 |
GeneticVariation
|
BEFREE |
We aimed to study the nine htSNPs in three haplotype blocks (block1: rs855211, rs35765, rs2162679; block2: rs1019731, rs7956547, rs5742632; and block3 rs2033178, rs7136446, rs6220) combined into diplotypes, and three additional SNPs (rs5742612, rs35765817, rs35455143) in relation to IGF-1 levels, BRCA status, the IGF1 CA-repeat microsatellite, and breast cancer in a population of 325 Swedish women from breast cancer high-risk families.
|
21113804 |
2011 |
|
rs6220
|
|
Malignant neoplasm of breast
|
|
0.030 |
GeneticVariation
|
BEFREE |
Also, rs6220 was associated with a significantly increased risk of breast cancer under the homozygote model (GG vs AA: OR, 1.23, 95% CI, 1.02-1.48, P = .031).
|
30572549 |
2018 |
|
rs6214
|
|
Colorectal Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
In this Dutch case-control study, DNA isolated from blood of 1,457 GI cancer patients; 438 patients with head and neck cancer (HNC), 475 with esophageal cancer (EC) and 544 with colorectal cancer (CRC) and 1,457 matched controls, was used to determine the rs6214 and rs6898743 genotypes by polymerase chain reaction.
|
24608110 |
2014 |
|
rs6214
|
|
Colorectal Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our results suggest that the SNP rs6214 of IGF1 could have an impact on developing colorectal cancer and colorectal polyps with villous elements.
|
19784788 |
2010 |