|
rs2910164
|
|
Primary malignant neoplasm of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
Thus, miR-146a rs2910164 polymorphism may influence susceptibility to lung cancer in Chinese nonsmoking females through targeting TRAF6.
|
27911870 |
2017 |
|
rs2910164
|
|
Stomach Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
These values were used in the quantitative synthesis to assess the strength of the association between the miR-146a rs2910164 polymorphism and risk of gastric cancer.
|
25386093 |
2014 |
|
rs2910164
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
No allelic variant was detected for hsa-mir-17 and hsa-mir-369, and allelic and genotype frequencies for miR-146a rs2910164 single-nucleotide polymorphism (SNP) were comparable with that of 155 controls from the same population, ruling out a role for genetic variations in these three miRNAs as major determinants in cancer predisposition of BRCA1/BRCA2-negative patients.
|
20810544 |
2010 |
|
rs2910164
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Here, we evaluated 101 paired samples (cancer and normal tissues) from non-small cell lung carcinoma (NSCLC) patients to study the genotype distribution of single nucleotide polymorphisms (SNPs) in miR-146a (rs2910164 C-G), miR-149 (rs2292832 C-T), miR-196a2 (rs11614913 C-T) and miR-499 (rs3746444 G-A) and their influence on the expression of respective miRNAs.
|
21902575 |
2011 |
|
rs2910164
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
We further performed functional studies of three microRNA variants associated with cancer (rs2910164:C > G in MIR146A, rs11614913:C > T in MIR196A2, and rs3746444:A > G in both MIR499A and MIR499B).
|
27397105 |
2016 |
|
rs2910164
|
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results suggest that the miR-146a rs2910164 polymorphism contributes to increased HCC susceptibility, especially in Asian populations.
|
25546664 |
2014 |
|
rs2910164
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, no significant association between has-miR-146a rs2910164 polymorphism and breast cancer risk was observed in all comparison models tested.
|
20640596 |
2011 |
|
rs2910164
|
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
These findings suggested that SNPs rs71428439 (miR-149), rs2910164 (miR-146a), rs928508 (mir-30c-1) and rs629367 (let-7a-2) were associated with the lung cancer prevalence, polymorphisms of rs11614913 (miR-196a-2) and rs9280508 (miR-30c-1) significantly influenced the patients' response to platinum-based chemotherapy, which may serve as potential clinical biomarkers to predict lung cancer risk and platinum-based chemotherapy response.
|
30069329 |
2018 |
|
rs2910164
|
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In particular, the association between SNPs in miRNA196a-2 (rs11614913) and miRNA146a (rs2910164) and HCC has been investigated.
|
24377545 |
2013 |
|
rs2910164
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Overall analysis showed that rs2910164 was not associated with BC susceptibility in any genetic model, whereas rs11614913 was associated with a decreased risk in both the allelic contrast and recessive models, and rs3746444 imparted an increased risk in all genetic models.
|
28978158 |
2017 |
|
rs2910164
|
|
Stomach Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our studies suggested that the miR-146a rs2910164 polymorphism might marginally contribute to a decreased risk of gastric cancer, especially in Caucasians, whereas the miR-196a2 rs11614913 polymorphism might not be associated with susceptibility to GC.
|
26406571 |
2015 |
|
rs2910164
|
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
Conclusion Our data indicate that miR-146a (rs2910164</span>) and miR-27a (rs895819) variants contribute to breast cancer.
|
29521182 |
2018 |
|
rs2910164
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
This meta-analysis suggests, for the first time, that the CC homozygote of rs2910164 may contribute to breast cancer susceptibility in Europeans.
|
22363684 |
2012 |
|
rs2910164
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the subgroups, rs2910164 and rs3746444 were only associated with CVDs, especially CAD.
|
30642078 |
2019 |
|
rs2910164
|
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
For miR-146a rs2910164, individuals carrying heterozygous CG or homozygous GG genotype had decreased risks of lung cancer compared with those carrying homozygous wild CC genotype (adjusted odds ratios were 0.76 and 0.64, 95% confidence intervals were 0.59-0.99 and 0.46-0.90, P values were 0.039 and 0.010, respectively).
|
26973201 |
2016 |
|
rs2910164
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
In contrast to the results of familial breast cancer studies, however, we found that the presence of the G allele of rs2910164 is associated with increased cancer risk, with an OR of 1.77 (95% CI 1.40-2.23).
|
26476291 |
2016 |
|
rs2910164
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
MiR-146a rs2910164 polymorphism and overall cancer susceptibility were significantly uncorrelated in all genetic models.
|
29127520 |
2018 |
|
rs2910164
|
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We did not find a significant association of miR-146aG>C rs2910164 and miR-499A>G rs3746444 polymorphisms with hepatocellular carcinoma risk in the Chinese population.
|
24301908 |
2013 |
|
rs2910164
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although recent studies focused on various diseases that harbor the miR-146aC>G (rs2910164), 149C>T (rs2292832), 196a2C>T (rs11614913), and 499A>G (rs3746444) polymorphisms, the role of miRNA genetic variants in colorectal cancer is still unknown.
|
22161766 |
2012 |
|
rs2910164
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The rs2910164 polymorphism has no association with breast cancer risk.
|
27880723 |
2017 |
|
rs2910164
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Hsa-mir-149C/T rs2292832 and hsa-mir-146a G/C rs2910164 may influence CRC risk in an ethnicity-dependent manner by interfering with CRC progression parameters in Tunisian cohort.
|
29715515 |
2018 |
|
rs2910164
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recent evidence suggests that the rs2910164 variant of miR-146a is associated with the development of certain types of malignancies.
|
26214637 |
2015 |
|
rs2910164
|
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
As a result, 15 SNPs on or near 12 genes and one miRNA with strong evidence of association with lung cancer risk were identified, including TERT (rs2736098), CHRNA3 (rs1051730), AGPHD1 (rs8034191), CLPTM1L (rs401681 and rs402710), BAT3 (rs3117582), TRNAA (rs4324798), ERCC2 (Lys751Gln), miR-146a2 (rs2910164), CYP1B1 (Arg48Gly), GSTM1 (null/present), SOD2 (C47T), IL-10 (-592C/A and -819C/T), and TP53 (intron 6).
|
29110844 |
2017 |
|
rs2910164
|
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our current meta-analysis demonstrates that miR-196a2 rs11614913 most likely contributes to decreased risk of CRC, whereas miR-146a rs2910164 may not be associated with the susceptibility to CRC.
|
24399071 |
2014 |
|
rs2910164
|
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
We further performed functional studies of three microRNA variants associated with cancer (rs2910164:C > G in MIR146A, rs11614913:C > T in MIR196A2, and rs3746444:A > G in both MIR499A and MIR499B).
|
27397105 |
2016 |