|
rs2910164
|
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
Thus, miR-146a rs2910164 polymorphism may influence susceptibility to lung cancer in Chinese nonsmoking females through targeting TRAF6.
|
27911870 |
2017 |
|
rs2910164
|
|
Primary malignant neoplasm of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
As a result, 15 SNPs on or near 12 genes and one miRNA with strong evidence of association with lung cancer risk were identified, including TERT (rs2736098), CHRNA3 (rs1051730), AGPHD1 (rs8034191), CLPTM1L (rs401681 and rs402710), BAT3 (rs3117582), TRNAA (rs4324798), ERCC2 (Lys751Gln), miR-146a2 (rs2910164), CYP1B1 (Arg48Gly), GSTM1 (null/present), SOD2 (C47T), IL-10 (-592C/A and -819C/T), and TP53 (intron 6).
|
29110844 |
2017 |
|
rs2910164
|
|
Rheumatoid Arthritis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Functional studies are required to investigate the exact role of miR-146a rs2910164 during RA.
|
28207326 |
2017 |
|
rs2910164
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The rs2910164 and rs16917496 SNPs were significantly associated with breast cancer (P=0.03 and 0.003, respectively).
|
29128203 |
2017 |
|
rs2910164
|
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, miR-146a C>G (rs2910164) can increase HBV-related HCC risk while miR-196a-2 C>T (rs11614913) may decrease the risk of HBV- and HCV-related HCC, especially in the Chinese population.
|
28148887 |
2017 |
|
rs2910164
|
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
Overall analysis showed that rs2910164 was not associated with BC susceptibility in any genetic model, whereas rs11614913 was associated with a decreased risk in both the allelic contrast and recessive models, and rs3746444 imparted an increased risk in all genetic models.
|
28978158 |
2017 |
|
rs2910164
|
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings supported the proposition that the polymorphisms of miR-146a rs2910164, miR-196a2 rs11614913, and miR-196a2 rs11614913 may contribute to the susceptibility of HCC.
|
28188097 |
2017 |
|
rs2910164
|
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Meanwhile, we demonstrated that the G allele of rs2910164 decreased the susce</span>ptibility of CAD.
|
28489066 |
2017 |
|
rs2910164
|
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
The rs2910164 polymorphism has no association with breast cancer risk.
|
27880723 |
2017 |
|
rs2910164
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The rs2910164 variant in <i>MIR146A</i> is significantly associated with DTC, but is not significantly associated with BC in this cohort.
|
28899898 |
2017 |
|
rs2910164
|
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation
|
BEFREE |
A significant association was found between rs2910164</span> and GC risk under all genetic models (CC vs. GG, OR = 0.76, 95% CI = 0.66-0.87; CC vs. GC+GG, OR = 0.84, 95% CI = 0.71-0.99; CC+GC vs. GG, OR = 0.82, 95% CI = 0.73-0.91) for the total data.
|
26202478 |
2017 |
|
rs2910164
|
|
Malignant neoplasm of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
Thus, miR-146a rs2910164 polymorphism may influence susceptibility to lung cancer in Chinese nonsmoking females through targeting TRAF6.
|
27911870 |
2017 |
|
rs2910164
|
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
The rs2910164 and rs16917496 SNPs were significantly associated with breast cancer (P=0.03 and 0.003, respectively).
|
29128203 |
2017 |
|
rs2910164
|
|
Stomach Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In summary, these results suggest that the miR-146a SNP rs2910164 may not be a risk factor for GCa in this Chinese population.
|
27105532 |
2016 |
|
rs2910164
|
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation
|
BEFREE |
In summary, these results suggest that the miR-146a SNP rs2910164 may not be a risk factor for GCa in this Chinese population.
|
27105532 |
2016 |
|
rs2910164
|
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation
|
BEFREE |
The overexpression of UHRF1 was correlated with the stage and grade of gastric cancer and is associated with the genotype distribution of rs2910164.
|
26896831 |
2016 |
|
rs2910164
|
|
Malignant neoplasm of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
For miR-146a rs2910164, individuals carrying heterozygous CG or homozygous GG genotype had decreased risks of lung cancer compared with those carrying homozygous wild CC genotype (adjusted odds ratios were 0.76 and 0.64, 95% confidence intervals were 0.59-0.99 and 0.46-0.90, P values were 0.039 and 0.010, respectively).
|
26973201 |
2016 |
|
rs2910164
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
We further performed functional studies of three microRNA variants associated with cancer (rs2910164:C > G in MIR146A, rs11614913:C > T in MIR196A2, and rs3746444:A > G in both MIR499A and MIR499B).
|
27397105 |
2016 |
|
rs2910164
|
|
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
For miR-146a rs2910164, individuals carrying heterozygous CG or homozygous GG genotype had decreased risks of lung cancer compared with those carrying homozygous wild CC genotype (adjusted odds ratios were 0.76 and 0.64, 95% confidence intervals were 0.59-0.99 and 0.46-0.90, P values were 0.039 and 0.010, respectively).
|
26973201 |
2016 |
|
rs2910164
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
In contrast to the results of familial breast cancer studies, however, we found that the presence of the G allele of rs2910164 is associated with increased cancer risk, with an OR of 1.77 (95% CI 1.40-2.23).
|
26476291 |
2016 |
|
rs2910164
|
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
We further performed functional studies of three microRNA variants associated with cancer (rs2910164:C > G in MIR146A, rs11614913:C > T in MIR196A2, and rs3746444:A > G in both MIR499A and MIR499B).
|
27397105 |
2016 |
|
rs2910164
|
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation
|
BEFREE |
rs2910164 of miR-146a is associated with GC.
|
27267319 |
2016 |
|
rs2910164
|
|
Malignant neoplasm of breast
|
|
0.100 |
GeneticVariation
|
BEFREE |
These verdicts may enhance our perceptions of how mir-146a rs2910164 affect expressed phenotypes in BC, and might have potential implications to develop BC treatment in future.
|
27434289 |
2016 |
|
rs2910164
|
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation
|
BEFREE |
In contrast to the results of familial breast cancer studies, however, we found that the presence of the G allele of rs2910164 is associated with increased cancer risk, with an OR of 1.77 (95% CI 1.40-2.23).
|
26476291 |
2016 |
|
rs2910164
|
|
Primary malignant neoplasm of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
These findings suggest that miR-146a rs2910164C>G and miR-423 rs6505162C>A polymorphisms may contribute to genetic susceptibility to lung cancer and lung adenocarcinoma in Chinese non-smoking females.
|
26973201 |
2016 |