Entrez Id: |
79728 |
Gene Symbol: |
PALB2 |
PALB2
|
Q86YC2
|
partner and localizer of BRCA2
|
|
260
|
0.485 |
0.769 |
3.0E-19 |
0.700 |
definitive
|
0.944 |
36
|
2
|
2006 |
2019 |
Entrez Id: |
7516 |
Gene Symbol: |
XRCC2 |
XRCC2
|
O43543
|
X-ray repair cross complementing 2
|
|
187
|
0.512 |
0.731 |
4.0E-07 |
0.530 |
limited
|
1.000 |
7
|
1
|
1999 |
2019 |
Entrez Id: |
5892 |
Gene Symbol: |
RAD51D |
RAD51D
|
O75771
|
RAD51 paralog D
|
|
36
|
0.674 |
0.385 |
1.1E-09 |
0.510 |
limited
|
1.000 |
9
|
1
|
2000 |
2019 |
Entrez Id: |
672 |
Gene Symbol: |
BRCA1 |
BRCA1
|
P38398
|
BRCA1 DNA repair associated
|
Enzyme
|
747
|
0.367 |
0.923 |
9.2E-29 |
0.400 |
None
|
0.946 |
297
|
12
|
1993 |
2019 |
Entrez Id: |
675 |
Gene Symbol: |
BRCA2 |
BRCA2
|
P51587
|
BRCA2 DNA repair associated
|
Nucleic acid binding
|
656
|
0.379 |
0.846 |
2.4E-25 |
0.400 |
None
|
0.961 |
205
|
3
|
1995 |
2019 |
Entrez Id: |
11200 |
Gene Symbol: |
CHEK2 |
CHEK2
|
O96017
|
checkpoint kinase 2
|
Kinase
|
297
|
0.460 |
0.808 |
1.2E-24 |
0.400 |
definitive
|
0.939 |
33
|
0
|
2000 |
2019 |
Entrez Id: |
472 |
Gene Symbol: |
ATM |
ATM
|
Q13315
|
ATM serine/threonine kinase
|
Kinase
|
684
|
0.374 |
0.885 |
5.6E-47 |
0.400 |
definitive
|
1.000 |
22
|
2
|
1998 |
2019 |
Entrez Id: |
580 |
Gene Symbol: |
BARD1 |
BARD1
|
Q99728
|
BRCA1 associated RING domain 1
|
|
75
|
0.597 |
0.538 |
1.4E-24 |
0.350 |
definitive
|
0.938 |
16
|
4
|
2001 |
2019 |
Entrez Id: |
4683 |
Gene Symbol: |
NBN |
NBN
|
O60934
|
nibrin
|
Nucleic acid binding
|
291
|
0.467 |
0.808 |
2.2E-16 |
0.340 |
limited
|
0.750 |
8
|
0
|
2000 |
2018 |
Entrez Id: |
10111 |
Gene Symbol: |
RAD50 |
RAD50
|
Q92878
|
RAD50 double strand break repair protein
|
|
110
|
0.556 |
0.808 |
3.4E-27 |
0.340 |
limited
|
0.714 |
7
|
0
|
2003 |
2017 |
Entrez Id: |
84464 |
Gene Symbol: |
SLX4 |
SLX4
|
Q8IY92
|
SLX4 structure-specific endonuclease subunit
|
|
123
|
0.565 |
0.731 |
1.6E-22 |
0.330 |
limited
|
1.000 |
10
|
0
|
2011 |
2017 |
Entrez Id: |
5889 |
Gene Symbol: |
RAD51C |
RAD51C
|
O43502
|
RAD51 paralog C
|
|
162
|
0.533 |
0.692 |
6.2E-14 |
0.320 |
disputed
|
1.000 |
9
|
1
|
2010 |
2019 |
Entrez Id: |
4292 |
Gene Symbol: |
MLH1 |
MLH1
|
P40692
|
mutL homolog 1
|
Nucleic acid binding
|
526
|
0.399 |
0.808 |
3.4E-05 |
0.320 |
disputed
|
1.000 |
8
|
0
|
2000 |
2017 |
Entrez Id: |
4361 |
Gene Symbol: |
MRE11 |
MRE11
|
P49959
|
MRE11 homolog, double strand break repair nuclease
|
|
171
|
0.527 |
0.808 |
1.3E-12 |
0.320 |
disputed
|
1.000 |
7
|
1
|
1998 |
2017 |
Entrez Id: |
5965 |
Gene Symbol: |
RECQL |
RECQL
|
P46063
|
RecQ like helicase
|
Enzyme
|
58
|
0.615 |
0.615 |
1.5E-20 |
0.320 |
moderate
|
1.000 |
6
|
0
|
2005 |
2019 |
Entrez Id: |
1111 |
Gene Symbol: |
CHEK1 |
CHEK1
|
O14757
|
checkpoint kinase 1
|
Kinase
|
195
|
0.492 |
0.808 |
3.1E-08 |
0.320 |
|
1.000 |
2
|
0
|
2003 |
2010 |
Entrez Id: |
4595 |
Gene Symbol: |
MUTYH |
MUTYH
|
Q9UIF7
|
mutY DNA glycosylase
|
Enzyme
|
156
|
0.521 |
0.769 |
1.3E-18 |
0.320 |
|
0.500 |
2
|
0
|
2009 |
2017 |
Entrez Id: |
999 |
Gene Symbol: |
CDH1 |
CDH1
|
P12830
|
cadherin 1
|
|
508
|
0.401 |
0.808 |
0.15 |
0.310 |
definitive
|
1.000 |
13
|
0
|
1991 |
2018 |
Entrez Id: |
79648 |
Gene Symbol: |
MCPH1 |
MCPH1
|
Q8NEM0
|
microcephalin 1
|
Nucleic acid binding
|
141
|
0.540 |
0.846 |
7.8E-30 |
0.310 |
limited
|
1.000 |
7
|
0
|
2005 |
2016 |
Entrez Id: |
2956 |
Gene Symbol: |
MSH6 |
MSH6
|
P52701
|
mutS homolog 6
|
Nucleic acid binding
|
296
|
0.462 |
0.731 |
3.7E-05 |
0.310 |
disputed
|
1.000 |
5
|
1
|
2002 |
2018 |
Entrez Id: |
4436 |
Gene Symbol: |
MSH2 |
MSH2
|
P43246
|
mutS homolog 2
|
Nucleic acid binding
|
490
|
0.406 |
0.808 |
0.90 |
0.310 |
disputed
|
1.000 |
3
|
0
|
2003 |
2017 |
Entrez Id: |
8493 |
Gene Symbol: |
PPM1D |
PPM1D
|
O15297
|
protein phosphatase, Mg2+/Mn2+ dependent 1D
|
Enzyme
|
177
|
0.513 |
0.808 |
2.2E-11 |
0.310 |
None
|
1.000 |
1
|
0
|
2019 |
2019 |
Entrez Id: |
348654 |
Gene Symbol: |
GEN1 |
GEN1
|
Q17RS7
|
GEN1 Holliday junction 5' flap endonuclease
|
|
35
|
0.682 |
0.500 |
3.7E-15 |
0.300 |
disputed
|
1.000 |
6
|
0
|
2011 |
2016 |
Entrez Id: |
60561 |
Gene Symbol: |
RINT1 |
RINT1
|
Q6NUQ1
|
RAD50 interactor 1
|
|
19
|
0.743 |
0.231 |
5.3E-13 |
0.300 |
disputed
|
1.000 |
5
|
0
|
2001 |
2016 |
Entrez Id: |
5395 |
Gene Symbol: |
PMS2 |
PMS2
|
P54278
|
PMS1 homolog 2, mismatch repair system component
|
Nucleic acid binding
|
244
|
0.484 |
0.808 |
4.5E-27 |
0.300 |
disputed
|
1.000 |
4
|
0
|
1995 |
2018 |